{"id":67,"date":"2013-05-31T14:23:53","date_gmt":"2013-05-31T18:23:53","guid":{"rendered":"https:\/\/sites.bu.edu\/rameh-lab\/?page_id=67"},"modified":"2013-06-03T23:25:00","modified_gmt":"2013-06-04T03:25:00","slug":"pi-5-p","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/rameh-lab\/pi-5-p\/","title":{"rendered":"PI-5-P"},"content":{"rendered":"<p>We are currently focusing our research on understanding the function of a  novel phosphoinositide molecule, PI-5-P, and the enzyme that uses  it as substrate, the PI-5-P 4-kinase. PI-5-P levels are normally low but  can be induced by extracellular factors, in response to stress or  during bacterial invasion. Our goal is to determine how PI-5-P  levels are regulated in mammalian cells, to identify its cellular  targets and to understand how it affects cellular function in cancer and  diabetes.<\/p>\n<p><a href=\"\/rameh-lab\/files\/2013\/05\/Slide2.jpg\"><img loading=\"lazy\" class=\"size-medium wp-image-68 aligncenter\" title=\"PI-5-P\" alt=\"PI-5-P or PtdIns-5-P \" src=\"\/rameh-lab\/files\/2013\/05\/Slide2-636x477.jpg\" height=\"362\" width=\"483\" srcset=\"https:\/\/sites.bu.edu\/rameh-lab\/files\/2013\/05\/Slide2-636x477.jpg 636w, https:\/\/sites.bu.edu\/rameh-lab\/files\/2013\/05\/Slide2.jpg 720w\" sizes=\"(max-width: 483px) 100vw, 483px\" \/><\/a><\/p>\n<p>PI-5-P is the latest and likely the last phospholipid to be identified in the phosphoinositide family. The identification of PI-5-P was an accidental discovery that followed from Dr. Rameh\u2019s observation that a particular phosphoinositide phosphatase generated a lipid with properties that did not fit the profile of other well-characterized phosphoinositides.<\/p>\n<p><a href=\"\/rameh-lab\/files\/2013\/05\/Slide5.jpg\"><img loading=\"lazy\" class=\"aligncenter size-medium wp-image-75\" title=\"Pathways for PI-4,5-P2 synthesis\" alt=\"Pathways for PI-4,5-P2 synthesis\" src=\"\/rameh-lab\/files\/2013\/05\/Slide5-636x477.jpg\" height=\"420\" width=\"560\" srcset=\"https:\/\/sites.bu.edu\/rameh-lab\/files\/2013\/05\/Slide5-636x477.jpg 636w, https:\/\/sites.bu.edu\/rameh-lab\/files\/2013\/05\/Slide5.jpg 720w\" sizes=\"(max-width: 560px) 100vw, 560px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>We are currently focusing our research on understanding the function of a novel phosphoinositide molecule, PI-5-P, and the enzyme that uses it as substrate, the PI-5-P 4-kinase. PI-5-P levels are normally low but can be induced by extracellular factors, in response to stress or during bacterial invasion. Our goal is to determine how PI-5-P levels [&hellip;]<\/p>\n","protected":false},"author":7363,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/pages\/67"}],"collection":[{"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/users\/7363"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/comments?post=67"}],"version-history":[{"count":31,"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/pages\/67\/revisions"}],"predecessor-version":[{"id":244,"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/pages\/67\/revisions\/244"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/rameh-lab\/wp-json\/wp\/v2\/media?parent=67"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}