Publications

1. Rameh LE, Tolias KF, Duckworth BC & Cantley LC. A new pathway for phosphatidylinositol-4,5-bisphosphate synthesis. Nature 1997; 390: 192-195. PMID: 9367159.

2. Tolias KF, Rameh LE, Ishihara H, Shibasaki Y, Cantley LC & Carpenter CL. Type I Phosphatidylinositol-4-phosphate 5-Kinases Synthesize the Novel Lipid Phosphatidylinositol-3,5-bisphosphate. J. Biol. Chem. 1998; 273: 18040-18046. PMID: 9660759.

3. Rameh LE, Rhee SG, Spokes K, Kazlauskas A, Cantley LC & Cantley LG. Phosphoinositide 3-kinase regulates Phospholipase C mediated Calcium Signaling. J. Biol. Chem. 1998; 273: 23750-23757. PMID: 9726983.

4. Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC & Rameh LE. The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation. PNAS 2003; 100: 9867-9872. PMID: 12897244; PMC187868.

5. Chang JD, Field SJ, Rameh LE, Carpenter CL & Cantley LC. Identification and characterization of a phosphoinositide phosphate kinase homolog. J Biol Chem. 2004; 279(12):11672-9. PMID: 14701839.

6. Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB & Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Mol Cell Biol. 2004; 24(11):5080-7. PMID: 15143198; PMC416424.

7. Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC & Ross AH. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. J Cell Biol. 2004; 166(2):205-11. PMID: 15249580; PMC2172303.

8. Mason D, Mallo GV, Terebiznik MR, Payrastre B, Finlay BB, Brumell JH, Rameh L & Grinstein S. Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase. J Gen Physiol. 2007; 129(4):267-83. PMID: 17389247; PMC2151621.

9. Mandl A, Sarkes D, Carricaburu V, Jung V & Rameh L. Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN. Mol. Cell Biol. 2007; 27(23):8098-112. PMID: 17893321; PMC2169165.

10. Mallo GV, Smith AC, Terebiznik MR, Aleman A, Finlay BB, Rameh L, Grinstein S & Brumell JH. SopB promotes phosphatidylinositol 3-phosphate formation on Salmonella vacuoles by recruiting Rab5 and VPS34. J.Cell Biol. 2008; 182(4): 741-52. PMID: 18725540; PMC2518712.

11. Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadan D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP and Cantley LC. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 2009; 16 (2): 115-125. PMID: 19647222.

12. Demian DJ, Clugston SL, Foster MM, Rameh L, Sarkes D, Townson SA, Yang L, Zhang M, Charlton ME. High-throughput, cell-free, liposome-based approach for assessing in vitro activity of lipid kinases. J Biomol Screen 2009; 14(7):838-44. PMID: 19641220.

13. Sarkes D, Rameh LE. A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides. Biochem J. 2010; 428(3):375-84. PMID: 20370717.

14. Wesche J, Oppelt A, Lobert V, Haglund K, Mackey A, Rameh L, Liestøl K, Pedersen NM, Brech A, Rusten TE, Stenmark H, Schink K, Wenzel E and Haugsten E. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep. 2012; 14(1): 57-64. PMID: 23154468.

15. McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Nagle A, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TR, Henrich PP, Gagaring K, Ibanez M, Kato N, Kuhen KL, Fischli C, Rottmann M, Plouffe DM, Bursulaya B, Meister S, Rameh L, Trappe J, Haasen D, Timmerman M, Sauerwein RW, Suwanarusk R, Russell B, Renia L, Nosten F, Tully DC, Kocken CH, Glynne RJ, Bodenreider C, Fidock DA, Diagana TT, Winzeler EA. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 2013;504(7479):248-53. Epub 2013/11/29. doi: 10.1038/nature12782. PubMed PMID: 24284631.

16. Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, Denicola GM, Song J, Brown V, Signoretti S, Cantley LC. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013;155(4):844-57. Epub 2013/11/12. doi: 10.1016/j.cell.2013.09.057. PubMed PMID: 24209622.

17. Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J. AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Science signaling. 2013;6(279):ra45. Epub 2013/06/13. doi: 10.1126/scisignal.2004015. PubMed PMID: 23757022.

18. Mackey AM, Sarkes D, Bettencourt I, Asara JM and Rameh LE. PIP4kγ is a substrate for mTORC1 that maintains basal mTORC1 signaling during starvation. Science Signaling. 2014; 7 (350).For reprints of this paper use the following links:
Summary: Abstract Reprint Full Text

Reviews:

19. Rameh LE & Cantley LC. The role of phosphoinositide 3-kinase lipid products in cell function. J Biol Chem 1999; 274: 8347-50 PubMed PMID: 10085060.

20. Fruman DA, Rameh LE & Cantley LC. Phosphoinositide binding domains: embracing 3-phosphate. Cell 1999; 97: 817-20. PMID: 10399908.

Textbook Chapters:

21. Rameh LE. Type 2 PIP4-kinases. In Handbook of Cellular Signaling 2003; Academic Press: pp 129-133.

22. Rameh LE. Type 2 PIP4-kinases. Chapter 131, In Handbook of Cellular Signaling 2010, Three-Volume Set2 edn (Bradshaw, R.A. and Dennis, E.A., eds), pp1043-1048, Elsevier.