{"id":53,"date":"2021-07-13T13:44:09","date_gmt":"2021-07-13T17:44:09","guid":{"rendered":"https:\/\/sites.bu.edu\/ramachandranlab\/?page_id=53"},"modified":"2026-01-22T08:40:05","modified_gmt":"2026-01-22T13:40:05","slug":"research","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/ramachandranlab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<figure id=\"attachment_658\" aria-describedby=\"caption-attachment-658\" style=\"width: 298px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" src=\"\/ramachandranlab\/files\/2022\/01\/mode_pyramid3-627x636.png\" alt=\"Examples of Laguerre-Gaussian modes of light.\" class=\"wp-image-658\" width=\"288\" height=\"292\" srcset=\"https:\/\/sites.bu.edu\/ramachandranlab\/files\/2022\/01\/mode_pyramid3-627x636.png 627w, https:\/\/sites.bu.edu\/ramachandranlab\/files\/2022\/01\/mode_pyramid3-1010x1024.png 1010w, https:\/\/sites.bu.edu\/ramachandranlab\/files\/2022\/01\/mode_pyramid3-768x779.png 768w, https:\/\/sites.bu.edu\/ramachandranlab\/files\/2022\/01\/mode_pyramid3-100x100.png 100w, https:\/\/sites.bu.edu\/ramachandranlab\/files\/2022\/01\/mode_pyramid3.png 1371w\" sizes=\"(max-width: 288px) 100vw, 288px\" \/><figcaption id=\"caption-attachment-658\" class=\"wp-caption-text\">Examples of higher-order light beams with singularities. Structured light can have exotic diffractive and dispersive properties in free space and optical fibers, such as the ability to self-heal or carry orbital angular momentum.<\/figcaption><\/figure>\n<figure id=\"attachment_661\" aria-describedby=\"caption-attachment-661\" style=\"width: 316px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" src=\"\/ramachandranlab\/files\/2022\/01\/microscope_w_border.gif\" alt=\"Video from data taken with a two-photon microscope\" class=\"wp-image-661\" width=\"306\" height=\"292\" \/><figcaption id=\"caption-attachment-661\" class=\"wp-caption-text\">Video depicting calcium activity of living neurons in the mouse cortex. Next generation microscopes leveraging ultra-fast, nonlinear interactions of structured light beams can improve penetration depth and information throughput for neuroscience.<\/figcaption><\/figure>\n<figure id=\"attachment_621\" aria-describedby=\"caption-attachment-621\" style=\"width: 448px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" src=\"\/ramachandranlab\/files\/2022\/01\/ssmc-636x424.png\" alt=\"Research figure detailing the process of Soliton Self-Mode Conversion throughout fiber propagation\" class=\"wp-image-621\" width=\"438\" height=\"292\" srcset=\"https:\/\/sites.bu.edu\/ramachandranlab\/files\/2022\/01\/ssmc-636x424.png 636w, https:\/\/sites.bu.edu\/ramachandranlab\/files\/2022\/01\/ssmc-1024x682.png 1024w, https:\/\/sites.bu.edu\/ramachandranlab\/files\/2022\/01\/ssmc-768x512.png 768w, https:\/\/sites.bu.edu\/ramachandranlab\/files\/2022\/01\/ssmc-1536x1023.png 1536w, https:\/\/sites.bu.edu\/ramachandranlab\/files\/2022\/01\/ssmc-2048x1364.png 2048w\" sizes=\"(max-width: 438px) 100vw, 438px\" \/><figcaption id=\"caption-attachment-621\" class=\"wp-caption-text\">Spatiotemporal nonlinear dynamics of ultra-fast pulses in highly multi-mode optical fibers. Nonlinear fiber optics exploiting the spatial degree of freedom \u2013 i.e. interactions between fiber modes \u2013 opens up new applications in quantum information, high power lasers, and biomedical imaging, amongst many others.<\/figcaption><\/figure>\n<h3 style=\"text-align: left;\"><span style=\"text-decoration: underline;\"><br style=\"clear: both;\" \/>Physics &amp; Applications of Singular Light<br \/>\n<\/span><\/h3>\n<p style=\"text-align: justify;\">When we think of light, we think of a Gaussian-shaped spot, usually traveling in a straight line except when it encounters interfaces. This is, however, only the first, fundamental solution of the wave equation \u2013 much as a guitar string can have many modes (and frequencies) of vibrations, so can light also exist in different eigenstates. These peculiarly shaped light beams are characterized by singularities \u2013 i.e., regions in which some quantity does not have a well-defined value \u2013 in polarization, phase or amplitude. The physics of propagation of such beams reveals exotic effects, such as the ability of the beam to self-heal past obstructions (<strong>Bessel beams<\/strong>), the ability to carry <strong>orbital angular momentum (OAM)<\/strong> that makes light travel in helical paths rather than a straight line, or even the possibility of retaining <strong>memory<\/strong> of the paths that it takes. Analogous to the physics of tornadoes as well as electron orbitals, these beams reveal several unique <strong>classical <\/strong>and <strong>quantum<\/strong> properties not normally observed with conventional Gaussian beams. We study these fundamental properties and also apply them to varied applications such as <strong>high-capacity classical communications<\/strong> that consume <strong>low energy per bit<\/strong>, high-speed metrology including object sensing for <strong>autonomous systems<\/strong> as well as <strong>spectrometry <\/strong>and<strong> imaging<\/strong>.<\/p>\n<p><a href=\"https:\/\/sites.bu.edu\/ramachandranlab\/ramachandran_tcm_talk\/\">Talk by Prof. Ramachandran on Topologically Confined Modes<\/a><\/p>\n<details>\n<summary><strong>Representative Publications<\/strong><\/summary>\n<ol>\n<li><span>D. I. Shahar, H. B. Kabag\u00f6z, and S. Ramachandran &#8220;<a href=\"https:\/\/doi.org\/10.1063\/5.0172305\">Generation of spatial combs digitized by orbital angular momentum<\/a><\/span><span>,&#8221; <em>APL Photonics<\/em>\u00a0 <strong>9,<\/strong>\u00a0016113 (2024).<\/span><\/li>\n<li>Z. Ma, P. Kristensen and S. Ramachandran, \u201c<span><a href=\"https:\/\/doi.org\/10.1126\/science.add1874\">Scaling information pathways in optical fibers by topological confinement<\/a>,\u201d <strong><em>Science<\/em><\/strong> <strong>380<\/strong>, 278-282 (2023).<\/span><\/li>\n<li><span>A.D. White, L. Su, D.I. Shahar, K.Y. Yang, G.Ho Ahn, J.L. Skarda, S. Ramachandran, J. Vu\u010dkovi\u0107, &#8220;<a href=\"https:\/\/doi.org\/10.1021\/acsphotonics.2c01007\">Inverse Design of Optical Vortex Beam Emitters<\/a><\/span><span>,&#8221; <em>ACS Photonics<\/em> <strong>10<\/strong>, 803 (2023).<\/span><\/li>\n<li>Z. Ma and S. Ramachandran, \u201c<a href=\"https:\/\/doi.org\/10.1515\/nanoph-2020-0404\">Propagation stability in optical fibers: role of path memory and angular momentum<\/a>,\u201d <em>Nanophotonics<\/em> <strong>10<\/strong>, 209 (2021).<\/li>\n<li>A. P. Greenberg, G. Prabhakar, and S. Ramachandran, \u201c<a href=\"https:\/\/doi.org\/10.1038\/s41467-020-18931-6\">High resolution spectral metrology leveraging topologically enhanced optical activity in fibers<\/a>,\u201d <em>Nature Communications<\/em> <strong>11<\/strong>, 5257 (2020).<\/li>\n<li>P. Gregg, P. Kristensen, A. Rubano, S. Golowich, L. Marrucci and S. Ramachandran, \u201c<a href=\"http:\/\/doi.org\/10.1038\/s41467-019-12401-4\">Enhanced Spin Orbit Interaction of Light in Highly Confining Optical Fibers for Mode Division Multiplexing<\/a>,\u201d <em>Nature Communications<\/em> <strong>10<\/strong>, 4707 (2019).<\/li>\n<li>D. Cozzolino, D. Bacco, B.D. Lio, K. Ingerslev, Y. Ding, K. Dalgaard, P. Kristensen, M. Galili, K. Rottwitt, S. Ramachandran, L.K. Oxenl\u00f8we, \u201c<a href=\"https:\/\/doi.org\/10.1103\/PhysRevApplied.11.064058\">Orbital Angular Momentum States Enabling Fiber-based High-dimensional Quantum Communication<\/a>,\u201d <em>Phys. Rev. Applied<\/em> <strong>11<\/strong>, 064058 (2019).<\/li>\n<li>D. L. P. Vitullo, C.C. Leary, P. Gregg, R.A. Smith, D.V. Reddy, S. Ramachandran and M. G. Raymer, \u201c<a href=\"https:\/\/doi.org\/10.1103\/PhysRevLett.118.083601\">Observation of Interaction of Spin and Intrinsic Orbital Angular Momentum of Light<\/a>,&#8221; <em>Phys. Rev. Lett.<\/em> <strong>118<\/strong>, 083601 (2017).<\/li>\n<li>B. N. Tugchin, N. Janunts, M. Steinert, K. Dietrich, D. Sivun, S. Ramachandran, K.V. Nerkararyan, A. T\u00fcnnermann, T. Pertsch, \u201c<a href=\"https:\/\/doi.org\/10.1039\/C6RA09341H\">Controlling the excitation of radially polarized conical plasmons in plasmonic tips in liquids<\/a>,\u201d <em>RSC Advances<\/em>, <strong>6<\/strong>, 53273 (2016).<\/li>\n<li>N. Bozinovic, Y. Yue, Y. Ren, M. Tur, P. Kristensen, H Huang, A.E. Willner, and S. Ramachandran, \u201c<span><a href=\"http:\/\/dx.doi.org\/10.1126\/science.1237861\">Terabit-Scale Orbital Angular Momentum Mode Division Multiplexing in Fibers<\/a><\/span>,\u201d <strong><em>Science<\/em><\/strong> <strong>340<\/strong>, 1545 (2013).<\/li>\n<\/ol>\n<\/details>\n<h3><span style=\"text-decoration: underline;\">Spatio-temporal &amp; Ultra-fast Microscopy<\/span><\/h3>\n<p style=\"text-align: justify;\">Optical imaging techniques such as fluorescence, confocal, or multiphoton microscopy, have allowed scientists to study the properties and function of living <strong>biological tissues<\/strong>, such as the <strong>mammalian brain<\/strong>. However, refractive index inhomogeneity in living tissue leads to scattering of input light fields, which reduces the penetration depth at which useful information about the sample can be gleaned. We aim to study how tailoring of <strong>nonlinear interactions between ultra-fast pulses<\/strong> of light \u2013 both inside and outside of biological samples \u2013 can be used to enhance <strong>signals from deep within the tissue<\/strong>. Furthermore, we study how the use of <strong>structured light<\/strong> \u2013 <em>i.e.<\/em> light with spatial profiles more complex than a conventional Gaussian beam \u2013 can be used to improve information throughput in biological imaging in order to develop <strong>state-of-the-art microscopy methods for neuroscience<\/strong> and life science at large.<\/p>\n<details>\n<summary><strong>Representative Publications<\/strong><\/summary>\n<ol>\n<li>J. Demas, J. Manley, F. Tejera, K. Barber, H. Kim, F. M. Traub, B. Chen, and A. Vaziri, \u201c<a href=\"https:\/\/doi.org\/10.1038\/s41592-021-01239-8\">High-speed, cortex-wide volumetric recording of neuroactivity at cellular resolution using light beads microscopy<\/a>,\u201d <em>Nature Methods <\/em><strong>18<\/strong>, 1103 (2021).<\/li>\n<li>S. Weisenburger, F. Tejera, J. Demas, <em>et al.<\/em>, \u201c<a href=\"https:\/\/doi.org\/10.1016\/j.cell.2019.03.011\">Volumetric Ca<sup>2+<\/sup> Imaging in the Mouse Brain Using Hybrid Multiplexed Sculpted Light Microscopy<\/a>,\u201d <em>Cell<\/em> <strong>177<\/strong>, 1050 (2019).<\/li>\n<li>L. Rish\u00f8j, B. Tai, P. Kristensen, and S. Ramachandran, \u201c<a href=\"https:\/\/doi.org\/10.1364\/OPTICA.6.000304\">Soliton self-mode conversion: revisiting Raman scattering of ultrashort pulses<\/a>,\u201d\u00a0<em>Optica<\/em>\u00a0<strong>6<\/strong>, 304 (2019).<\/li>\n<li>L. Yan, P. Kristensen, S. Ramachandran, \u201c<a href=\"https:\/\/doi.org\/10.1063\/1.5045233\">Vortex fibers for stimulated emission depletion (STED) microscopy<\/a>,\u201d\u00a0<em>APL Photonics<\/em>\u00a0<strong>4<\/strong>, 022903 (2019).<\/li>\n<li>L. Yan, P. Gregg, E. Karimi, A. Rubano, L. Marrucci, R. Boyd and S. Ramachandran, \u201c<a href=\"http:\/\/dx.doi.org\/10.1364\/OPTICA.2.000900\">Q-plate enabled spectrally diverse orbital-angular-momentum conversion for STED microscopy<\/a>,\u201d\u00a0<em>Optica<\/em> <strong>2<\/strong>, 900 (2015).<\/li>\n<\/ol>\n<\/details>\n<h3 style=\"text-align: left;\"><span style=\"text-decoration: underline;\">Nonlinear &amp; Quantum Photonics<\/span><\/h3>\n<p style=\"text-align: justify;\">Nonlinear optical phenomena represent the interaction of light with the material in which it propagates, resulting in myriad effects such as the ability to controllably alter its color and shape in both time and space. Because such effects perturb the principle of superposition in linear optics, nonlinear optics is one of the best known means of generating <strong>quantum entanglement<\/strong>. We study new nonlinear optical phenomena enabled by singular and structured light beams, such as new modal selection rules for <strong>Raman &amp; Brillouin scattering<\/strong> and the ability to obtain <strong>hyper- <\/strong>or <strong>hybrid-quantum entanglement<\/strong>. We then exploit these unique effects for applications such as single-photon frequency conversion for <strong>quantum networks<\/strong>, and for developing <strong>high-power lasers<\/strong> in the long-pulse as well as <strong>ultra-fast<\/strong> regime, for myriad uses ranging from <strong>biomedical imaging<\/strong> to <strong>LIDAR-based sensing <\/strong>and<strong> underwater communications<\/strong>.<\/p>\n<p><a href=\"https:\/\/sites.bu.edu\/ramachandranlab\/files\/2023\/10\/MMNLO_shortcourse_ASSL_2023.pdf\">Short Course by Prof. Ramachandran on Multimode Nonlinearities<\/a><\/p>\n<details>\n<summary><strong>Representative Publications<\/strong><\/summary>\n<ol>\n<li><span>X. Liu, D.I. Shahar, D.B. Kim, V.O. Lorenz, and S. Ramachandran, &#8220;<a href=\"https:\/\/doi.org\/10.1364\/OPTICAQ.560642\">Generation and engineering of orbital angular momentum biphotons in optical fibers<\/a><\/span><span>,&#8221; <em>Optica Quantum<\/em> <strong>3<\/strong>, 280-288 (2025).<\/span><\/li>\n<li><span>Aku Antikainen and Siddharth Ramachandran, &#8220;<a href=\"https:\/\/doi.org\/10.1364\/JOSAB.542582\">Fundamental limits on fiber-based electron acceleration-and how to overcome them<\/a><\/span><span>,&#8221; <em>J. Opt. Soc. Am. B<\/em> <strong>42<\/strong>, 587-596 (2025).<\/span><\/li>\n<li><span>Ilaria Cristiani <em>et al<\/em>, \u201c<a href=\"https:\/\/doi.org\/10.1088\/2040-8986\/ac7a48\">Roadmap on multimode photonics<\/a>,\u201d <strong>Invited Paper<\/strong>, <em> Opt.<\/em> <strong>24<\/strong>, 083001 (2022).<\/span><\/li>\n<li>X. Liu, Z. Ma, A. Antikainen, S. Ramachandran, \u201c<span><a href=\"https:\/\/doi.org\/10.1364\/OE.457259\">Raman gain control in optical fibers with orbital-angular-momentum-induced chirality of light<\/a>,\u201d <em>Opt. Express<\/em> <strong>30<\/strong>, 26967-26974 (2022).<\/span><\/li>\n<li>R. Lindberg, X. Liu, A. Zukauskas, S. Ramachandran and V. Pasiskevicius, &#8220;<a href=\"https:\/\/doi.org\/10.1364\/JOSAB.436188\">Simultaneous nonlinear wavelength and mode conversion for high-brightness blue sources<\/a>,&#8221; <em>J. Opt. Soc. Am. B<\/em> <strong>38<\/strong>, 3491 (2021).<\/li>\n<li>X. Liu, E.N. Christensen, K. Rottwitt and S. Ramachandran, \u201c<a href=\"https:\/\/doi.org\/10.1063\/1.5130715\">Nonlinear four-wave mixing with enhanced diversity and selectivity via spin and orbital angular momentum conservation<\/a>,\u201d <em>APL Photonics<\/em> <strong>5<\/strong>, 010802 (2020).<\/li>\n<li>G. Prabhakar, P. Gregg, L. Rishoj, P. Kristensen, and S. Ramachandran, &#8220;<a href=\"https:\/\/doi.org\/10.1364\/OE.27.011547\">Octave-wide supercontinuum generation of light-carrying orbital angular momentum<\/a>,&#8221; Opt. Express <strong>27<\/strong>, 11547-11556 (2019).<\/li>\n<li>L. Rish\u00f8j, B. Tai, P. Kristensen, and S. Ramachandran, &#8220;<a href=\"https:\/\/doi.org\/10.1364\/OPTICA.6.000304\">Soliton self-mode conversion: revisiting Raman scattering of ultrashort pulses<\/a>,&#8221; <em>Optica<\/em> <strong>6<\/strong>, 304-308 (2019).<\/li>\n<li>M. Ordu, J. Guo, G.Ng Pack, P. Shah, S. Ramachandran, M.K. Hong, L.D. Ziegler, S.N. Basu and S. Erramilli, \u201c<a href=\"https:\/\/doi.org\/10.1063\/1.5003027\">Nonlinear optics in germanium mid-infrared fiber material: Detuning oscillations in femtosecond mid-infrared spectroscopy<\/a>,\u201d <em>AIP Advances<\/em> <strong>7<\/strong>, 095125 (2017).<\/li>\n<li><span>J. Demas, P. Steinvurzel, B. Tai, L. Rish\u00f8j, Y. Chen, and S. Ramachandran, \u201c<a href=\"http:\/\/dx.doi.org\/10.1364\/OPTICA.2.000014\">Intermodal nonlinear mixing with Bessel beams in optical fiber<\/a>,\u201d <em>Optica <\/em><strong>2<\/strong>, 14 (2015).<\/span><\/li>\n<\/ol>\n<\/details>\n","protected":false},"excerpt":{"rendered":"<p>Physics &amp; Applications of Singular Light When we think of light, we think of a Gaussian-shaped spot, usually traveling in a straight line except when it encounters interfaces. This is, however, only the first, fundamental solution of the wave equation \u2013 much as a guitar string can have many modes (and frequencies) of vibrations, so [&hellip;]<\/p>\n","protected":false},"author":19518,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/ramachandranlab\/wp-json\/wp\/v2\/pages\/53"}],"collection":[{"href":"https:\/\/sites.bu.edu\/ramachandranlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/ramachandranlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ramachandranlab\/wp-json\/wp\/v2\/users\/19518"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ramachandranlab\/wp-json\/wp\/v2\/comments?post=53"}],"version-history":[{"count":50,"href":"https:\/\/sites.bu.edu\/ramachandranlab\/wp-json\/wp\/v2\/pages\/53\/revisions"}],"predecessor-version":[{"id":1083,"href":"https:\/\/sites.bu.edu\/ramachandranlab\/wp-json\/wp\/v2\/pages\/53\/revisions\/1083"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/ramachandranlab\/wp-json\/wp\/v2\/media?parent=53"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}