{"id":74,"date":"2013-02-21T14:35:07","date_gmt":"2013-02-21T19:35:07","guid":{"rendered":"https:\/\/sites.bu.edu\/phis\/?page_id=74"},"modified":"2016-02-01T10:06:37","modified_gmt":"2016-02-01T15:06:37","slug":"history","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/phis\/history\/","title":{"rendered":"History"},"content":{"rendered":"

History<\/h1>\n

The Slone Epidemiology Center<\/a> studied factors in pregnancy that may be related to the health of newborns for 39 years. The\u00a0Pregnancy\u00a0Health Interview Study focused on the safety and risks of a wide range of environmental exposures (primarily medications). The outcomes of primary interest were birth defects and complications of pregnancy such as prematurity and pregnancy-induced hypertension.<\/p>\n

\n

This multicenter case-control study was conducted in the areas surrounding Nashville, Philadelphia and San Diego; the states of Massachusetts and Rhode Island, Southern New Hampshire; and portions of New York State. Infants with problems and a sample of healthy infants without birth problems were identified through special arrangements with either state birth defect registries or through regular contact with approximately 28 participating institutions. Mothers of these infants were invited to take part in a telephone interview conducted by trained nurse-interviewers. The interview included questions on medical history, previous pregnancies, nutrition, occupation, health behaviors, and smoking, as well as detailed questions on medication use and vaccines received in the period prior to conception through the entire pregnancy. In total, 51,448 women were interviewed, making this one of the largest studies of its kind.<\/p>\n

Sources of Funding:<\/strong><\/p>\n

    \n
  • National Institutes of Health (NICHD, NHLBI, NIOSH, NIEHS)<\/li>\n
  • MCH Research Grants Program<\/li>\n
  • Glaxo-Smith Kline, Sanofi Pasteur, Novartis Vaccine and Diagnostics, other manufacturers<\/li>\n
  • FDA Cooperative Agreement<\/li>\n
  • Biomedical Advanced Research and Development Authority (BARDA)<\/li>\n
  • Agency for Healthcare Research and Quality (AHRQ)<\/li>\n<\/ul>\n

    Study Period:<\/strong><\/p>\n

    1976 to 2015<\/p>\n

    Completed Data File:<\/strong><\/p>\n

    51,448\u00a0subjects<\/p>\n

    Associated Studies:<\/strong><\/p>\n

      \n
    • Genetic and Non-genetic Risk for Hirschsprung\u2019s Disease<\/li>\n
    • Phthalates in Medications and Risk of Male Genital Defects<\/li>\n
    • Risk Factors for Folic Acid-resistant Spina Bifida<\/li>\n
    • Teratogenicity of Drugs Most Commonly Used in Pregnancy<\/li>\n
    • Vaccines And Medications in Pregnancy Surveillance System (VAMPSS)<\/li>\n<\/ul>\n

      \u2013 H1N1 and Seasonal Influenza Vaccines and Antiviral Medications in Pregnancy
      \n\u2013 Asthma Medications in Pregnancy \u2014 A Demonstration Project
      \n\u2013 Menveo Meningococcal Vaccine in Pregnancy<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

      History The Slone Epidemiology Center studied factors in pregnancy that may be related to the health of newborns for 39 years. The\u00a0Pregnancy\u00a0Health Interview Study focused on the safety and risks of a wide range of environmental exposures (primarily medications). The outcomes of primary interest were birth defects and complications of pregnancy such as prematurity and […]<\/p>\n","protected":false},"author":7009,"featured_media":0,"parent":0,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/phis\/wp-json\/wp\/v2\/pages\/74"}],"collection":[{"href":"https:\/\/sites.bu.edu\/phis\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/phis\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/phis\/wp-json\/wp\/v2\/users\/7009"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/phis\/wp-json\/wp\/v2\/comments?post=74"}],"version-history":[{"count":17,"href":"https:\/\/sites.bu.edu\/phis\/wp-json\/wp\/v2\/pages\/74\/revisions"}],"predecessor-version":[{"id":653,"href":"https:\/\/sites.bu.edu\/phis\/wp-json\/wp\/v2\/pages\/74\/revisions\/653"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/phis\/wp-json\/wp\/v2\/media?parent=74"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}