{"id":85,"date":"2014-06-12T11:27:16","date_gmt":"2014-06-12T15:27:16","guid":{"rendered":"https:\/\/sites.bu.edu\/phenogeno\/?page_id=85"},"modified":"2014-07-17T16:59:22","modified_gmt":"2014-07-17T20:59:22","slug":"diabetes","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/phenogeno\/research\/systems-biology-of-disease\/diabetes\/","title":{"rendered":"Diabetes"},"content":{"rendered":"<h4><\/h4>\n<p>&nbsp;<\/p>\n<p>Selected publications are below.<\/p>\n<ol>\n<li><a href=\"\/phenogeno\/files\/2014\/06\/To-Supplement-or-Not-to-Supplement-A-Metabolic-Network-Framework-for-Human-Nutritional-Supplements.pdf\" target=\"_blank\">To supplement or not to supplement: a metabolic network framework for human nutritional supplements<\/a>. Nogiec CD, Kasif S. PLoS One. 2013;8(8):e68751. doi: 10.1371\/journal.pone.0068751. PMID: 23967053<\/li>\n<li><a href=\"\/phenogeno\/files\/2014\/06\/Deep-Sequencing-of-the-Oral-Microbiome-Reveals-Signatures-of-Periodontal-Disease.pdf\" target=\"_blank\">Deep sequencing of the oral microbiome reveals s signatures of periodontal disease<\/a>, Bo Liu<sup>1,2<\/sup>*, Lina Faller<sup>3<\/sup>*, Niels Klitgord<sup>3<\/sup>*, Varun Mazumdar<sup>3<\/sup>*, Mohammad Ghodsi<sup>1,2<\/sup>,Daniel D. Sommer<sup>1<\/sup>, Theodore R. Gibbons<sup>1,4<\/sup>, Todd J. Treangen<sup>1,10<\/sup>, Yi-Chien Chang<sup>3<\/sup>,Shan Li<sup>5<\/sup>, O. Colin Stine<sup>5<\/sup>, Hatice Hasturk<sup>8<\/sup>, Simon Kasif<sup>3,7,9<\/sup>, Daniel Segr\u00e8<sup>3,6,7<\/sup>#,\u00a0 Mihai Pop<sup>1,2,4<\/sup>#, Salomon Amar<sup>3,8<\/sup>#,, PLOS One, 2012<\/li>\n<li>Network Signatures of Insulin Resistance and Life Span, M. Liu, M. Mori, IS. Kohane, ME Patti, A. Goldfine, CR Kahn, S. Kasif, in preparation.<\/li>\n<li>Chris Nogiec, Allison Burkhart, Jonathan Dreyfuss, Simon Kasif* and ME Patti*, Metabolic Analysis of Insulin Resistance, in revision (contributed equally authors), in review.<\/li>\n<li>Towards a Personal Repeatome: A Genome-Wide Survey of Length Variation in Short Tandem Repeats in Human Gene Transcripts, in preparation.<\/li>\n<li><a href=\"\/phenogeno\/files\/2014\/06\/a-systems-biology-approach-identifies-inflammatory-abnormalities-between-mouse-strains-prior-to-development-of-metabolic-disease.pdf\" target=\"_blank\">A Systems Biology Approach Links Inflammation to the Predisposition to Metabolic Diseases in Mouse Strains<\/a>, Marcelo Mori*, Manway Liu*, Simon Kasif, Ron Kahn, Diabetes 2010.<\/li>\n<li>Transcriptome Analysis Reveals Parallel Dysregulation of Oxidative Metabolism and Inflammation in Muscle and Adipose Tissue With Progression of Insulin Resistance in Humans, Mary-Elizabeth Patti, Manway Liu, Wanzhu Jin, Carles Lerin, Jonathan Dreyfuss, Martha Vokes, Joshua Schroeder, Elizabeth Tatro, Peter Park, Isaac Kohane, Igor Leykin, Simon Kasif, and Allison Goldfine, in preparation.<\/li>\n<li><a href=\"\/phenogeno\/files\/2014\/06\/Triplet-Repeat-length-bias-and-variation-in-the-human-transcriptome.pdf\" target=\"_blank\">Triplet repeat length bias and variation in the human transcriptome<\/a>,\u00a0 Molla M*, Delcher A*, Cantor CR, Kasif S, Proc. of National Academy of Sciences, Oct. 2009, PMID: 19805156<\/li>\n<li><a href=\"\/phenogeno\/files\/2014\/06\/Integration-of-heterogeneous-expression-data-sets-extends-the-role-of-the-retinol-pathway-in-diabetes-and-insulin-resistence.pdf\">Integration of heterogeneous expression data sets extends the role of the retinol pathway in diabetes and insulin resistance<\/a>. Park PJ, Kong SW, Tebaldi T, Lai WR, Kasif S, Kohane IS. Bioinformatics. 2009 Dec 1;25(23):3121-7. Epub 2009 Sep 28.PMID: 19786482<\/li>\n<li><a href=\"\/phenogeno\/files\/2014\/06\/Biological-process-linkage-networks.pdf\">Biological process linkage networks<\/a>. Dotan-Cohen D, Letovsky S, Melkman AA, Kasif S. PLoS ONE. 2009;4(4):e5313. Epub 2009 Apr 23. PMID 19390589<\/li>\n<li><a href=\"\/phenogeno\/files\/2014\/06\/Accelerated-postnatal-growth-increases-lipogenic-gene-expression-and-adipocyte-size-in-low-birth-weight-mice.pdf\" target=\"_blank\">Accelerated postnatal growth increases lipogenic gene expression and adipocyte size in low-birth weight mice<\/a>. Isganaitis E, Jimenez-Chillaron J, Woo M, Chow A, DeCoste J, Vokes M, Liu M, Kasif S, Zavacki AM, Leshan RL, Myers MG, Patti ME. Diabetes. 2009 May;58(5):1192-200. Epub 2009 Feb 10. PMID: 19208909<\/li>\n<li><a href=\"\/phenogeno\/files\/2014\/06\/context-specific-protein-function-prediction.pdf\" target=\"_blank\">Context specific protein function prediction<\/a>. Nariai N, Kasif S. Genome Inform. 2007; 18:173-82. PMID: 18546485<\/li>\n<li>Tullai JW, Schaffer ME, Mullenbrock S, Sholder G, Kasif S, Cooper GM.\u00a0<a href=\"\/phenogeno\/files\/2014\/06\/Immediate-Early-and-Delayed-Primary-Response-Genes-are-Distinct-in-Function-and-Genomic-Architecture.pdf\">Immediate-early and delayed primary response genes are distinct in function and genomic architecture<\/a>, J Biol Chem. 2007 Jun 15;<\/li>\n<li>Tullai JW, Chen J, Schaffer ME, Kamenetsky E, Kasif S, Cooper GM.\u00a0<a href=\"\/phenogeno\/files\/2014\/06\/Genomic-functional-annotation-using-coevolution-profiles-of-gene-clusters.pdf\">Glycogen synthase kinase-3 represses cyclic AMP response element-binding protein (CREB)-targeted immediate early genes in quiescent cells<\/a>. J Biol Chem. 2007 Mar 30;282(13):9482-91. Epub 2007 Feb 3. PMID: 17277356<\/li>\n<li>Liu M, Liberzon A, Kong SW, Lai WR, Park PJ, Kohane IS, Kasif S.\u00a0<a href=\"\/phenogeno\/files\/2014\/06\/Network-based-analysis-of-affected-biological-processes-in-type-2-diabetes-models.pdf\" target=\"_blank\">Network-based analysis of affected biological processes in type 2 diabetes models<\/a>. PLoS Genet. 2007 Jun 15;3(6):e96. PMID:17571924<\/li>\n<li>Murali TM, Wu CJ, Kasif S.\u00a0<a href=\"\/phenogeno\/files\/2014\/06\/The-art-of-gene-function-prediction.pdf\" target=\"_blank\">The art of gene function prediction<\/a>. Nature Biotechnology. 2006 Dec;24(12):1474-5. PMID: 17160037<\/li>\n<li>Rachlin J, Cohen DD, Cantor C, Kasif S.\u00a0<a href=\"\/phenogeno\/files\/2014\/06\/Biological-context-networks-a-mosaic-view-of-the-interactome.pdf\" target=\"_blank\">Biological context networks: a mosaic view of the interactome<\/a>. Nature\/Embo. Mol Syst Biol. 2006;2:66. Epub 2006 Nov 28. PMID: 17130868<\/li>\n<li>Lee S, Kohane I, Kasif S.\u00a0<a href=\"\/phenogeno\/files\/2014\/06\/Genes-involved-in-complex-adaptive-processes-tend-to-have-highly-conserved-upstream-regions-in-mammalian-genomes.pdf\">Genes involved in complex adaptive processes tend to have highly conserved upstream regions in mammalian genomes<\/a>. BMC Genomics. 2005 Nov 27;6:168. PMID: 16309559<\/li>\n<li>Tullai JW, Schaffer ME, Mullenbrock S, Kasif S, Cooper GM.\u00a0<a href=\"\/phenogeno\/files\/2014\/06\/Identification-of-transcription-factor-binding-sites.pdf\" target=\"_blank\">Identification of transcription factor binding sites upstream of human genes regulated by the phosphatidylinositol 3-kinase and MEK\/ERK signaling pathways<\/a>. J Biol Chem. 2004 May 7;279(19):20167-77. Epub 2004 Feb 9. PMID: 14769801<\/li>\n<li>Su Y, Murali TM, Pavlovic V, Schaffer M, Kasif S.\u00a0<a href=\"\/phenogeno\/files\/2014\/06\/RankGene-identification-of-diagnostic-genes-based-on-expression-data.pdf\">RankGene: identification of diagnostic genes based on expression data<\/a>. Bioinformatics. 2003 Aug 12;19(12):1578-9. PMID: 12912841<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<h3><a title=\"Research\" href=\"https:\/\/sites.bu.edu\/phenogeno\/research\/\">&lt;BACK<\/a><\/h3>\n<h4><\/h4>\n<h4><a title=\"Systems Biology of Disease\" href=\"https:\/\/sites.bu.edu\/phenogeno\/research\/current-research-focus\/systems-biology-of-disease\/\">&lt;BACK<\/a><\/h4>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Selected publications are below. To supplement or not to supplement: a metabolic network framework for human nutritional supplements. Nogiec CD, Kasif S. PLoS One. 2013;8(8):e68751. doi: 10.1371\/journal.pone.0068751. PMID: 23967053 Deep sequencing of the oral microbiome reveals s signatures of periodontal disease, Bo Liu1,2*, Lina Faller3*, Niels Klitgord3*, Varun Mazumdar3*, Mohammad Ghodsi1,2,Daniel D. Sommer1, Theodore [&hellip;]<\/p>\n","protected":false},"author":8738,"featured_media":0,"parent":79,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"profiles.php","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/phenogeno\/wp-json\/wp\/v2\/pages\/85"}],"collection":[{"href":"https:\/\/sites.bu.edu\/phenogeno\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/phenogeno\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/phenogeno\/wp-json\/wp\/v2\/users\/8738"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/phenogeno\/wp-json\/wp\/v2\/comments?post=85"}],"version-history":[{"count":5,"href":"https:\/\/sites.bu.edu\/phenogeno\/wp-json\/wp\/v2\/pages\/85\/revisions"}],"predecessor-version":[{"id":505,"href":"https:\/\/sites.bu.edu\/phenogeno\/wp-json\/wp\/v2\/pages\/85\/revisions\/505"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/phenogeno\/wp-json\/wp\/v2\/pages\/79"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/phenogeno\/wp-json\/wp\/v2\/media?parent=85"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}