{"id":5,"date":"2018-08-30T13:25:49","date_gmt":"2018-08-30T17:25:49","guid":{"rendered":"https:\/\/sites.bu.edu\/perlstein\/perlstein-lab\/"},"modified":"2026-04-05T17:28:13","modified_gmt":"2026-04-05T21:28:13","slug":"perlstein-lab","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/perlstein\/","title":{"rendered":"Welcome to the Perlstein Lab"},"content":{"rendered":"<div style=\"text-align: center; padding: 20px 0 10px;\"><img src=\"https:\/\/sites.bu.edu\/perlstein\/files\/2026\/04\/lab-logo.png\" alt=\"Perlstein Lab Logo\" style=\"max-width: 220px; height: auto;\" \/><\/div>\n<p style=\"text-align: center;\"><em>Iron-sulfur clusters are ancient, essential cofactors that power genome maintenance, metabolism, and cellular life. The Perlstein Lab investigates the fundamental biochemistry of how cells build and deliver these metallocofactors \u2014 and how disruption or hijacking of this system impacts human health and disease.<\/em><\/p>\n<h2>Our Research<\/h2>\n<p>We focus on the Cytosolic Iron-Sulfur Cluster Assembly (CIA) pathway, uncovering the molecular rules that govern how cells identify and supply FeS cofactors to their protein clients. A defining discovery in this area \u2014 a conserved C-terminal tripeptide that serves as a CIA recognition signal \u2014 has opened new frontiers, including the emerging question of how viruses exploit host CIA machinery to fuel their own replication. Our lab takes an integrative approach, combining enzyme kinetics, yeast genetics, protein-protein interaction analysis, fluorescence-based assays, high-throughput screening, and mass spectrometry collaborations to tackle these questions from multiple angles.<\/p>\n<p><a href=\"https:\/\/sites.bu.edu\/perlstein\/research\/\">Learn more about our research \u2192<\/a><\/p>\n<h2>Training &amp; Community<\/h2>\n<p>Training scientists through both research and teaching is central to everything we do in the Perlstein Lab. We are proud of the diverse paths our alumni pursue \u2014 from Anastasiya Buzuk, now a postdoctoral fellow at Harvard Chemistry, to Christina Mole at New England BioLabs, and Wen Yi Low as teaching faculty at the University of Chicago.<\/p>\n<div style=\"width: 1280px;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-5-1\" width=\"1280\" height=\"720\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"\/perlstein\/files\/2020\/02\/LabSnapshots-2.mp4?_=1\" \/><a href=\"\/perlstein\/files\/2020\/02\/LabSnapshots-2.mp4\">\/perlstein\/files\/2020\/02\/LabSnapshots-2.mp4<\/a><\/video><\/div>\n<p><a href=\"https:\/\/sites.bu.edu\/perlstein\/people\/\">Meet the team \u2192<\/a><\/p>\n<h2>On the Horizon \u2014 Recent Preprints<\/h2>\n<ul>\n<li>Nar1 binds the CIA targeting complex via a bipartite interaction interface \u00b7 <a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.03.06.710161v1\" target=\"_blank\" rel=\"noopener\">Preprint<\/a><\/li>\n<li>A promiscuous metal site in Hepatitis B Virus X Protein binds an Fe-S cluster \u00b7 <a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.01.20.700672v1\" target=\"_blank\" rel=\"noopener\">Preprint<\/a><\/li>\n<li>Discovery of a [4Fe-4S] cluster in the PRRSV Nsp1\u03b1 leader protease \u00b7 <a href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.01.06.697956v1\" target=\"_blank\" rel=\"noopener\">Preprint<\/a><\/li>\n<\/ul>\n<p><a href=\"https:\/\/sites.bu.edu\/perlstein\/publications\/\">View all publications \u2192<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Iron-sulfur clusters are ancient, essential cofactors that power genome maintenance, metabolism, and cellular life. The Perlstein Lab investigates the fundamental biochemistry of how cells build and deliver these metallocofactors \u2014 and how disruption or hijacking of this system impacts human health and disease. Our Research We focus on the Cytosolic Iron-Sulfur Cluster Assembly (CIA) pathway, [&hellip;]<\/p>\n","protected":false},"author":10222,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/perlstein\/wp-json\/wp\/v2\/pages\/5"}],"collection":[{"href":"https:\/\/sites.bu.edu\/perlstein\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/perlstein\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/perlstein\/wp-json\/wp\/v2\/users\/10222"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/perlstein\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":18,"href":"https:\/\/sites.bu.edu\/perlstein\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":702,"href":"https:\/\/sites.bu.edu\/perlstein\/wp-json\/wp\/v2\/pages\/5\/revisions\/702"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/perlstein\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}