{"id":491,"date":"2014-02-27T15:04:13","date_gmt":"2014-02-27T20:04:13","guid":{"rendered":"http:\/\/blogs.bu.edu\/vperissi\/?page_id=4"},"modified":"2025-10-03T10:30:19","modified_gmt":"2025-10-03T14:30:19","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/perissilab\/publications\/","title":{"rendered":""},"content":{"rendered":"

<\/h3>\n
\"\"
Wordcloud from our published work (Created with Scholar Goggler in 2024)<\/figcaption><\/figure>\n

Most Recent Lab Publications<\/strong><\/h4>\n
\n
\n
    \n
  1. Ferrero G, Cardamone MD<\/span>, Luca F<\/span>, Bourk E, Ricci L, Liu W, Gao Y<\/span>, Burrone G<\/span>, Muhammad A<\/span>, Chan S<\/span>, Smith E<\/span>, Fan TC<\/span>, Cutrupi S, Garcia-Bassets I, De Bortoli M, Rosenfeld MG, Perissi V<\/span>. Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR\/SMRT\/HDAC3 corepressor complex in MCF-7 breast cancer cells<\/a>. Proc Natl Acad Sci U S A<\/strong><\/em>. 2025 May 6;122(18):e2502805122.\u00a0<\/span><\/li>\n
  2. Gao Y, Kwan J, Orofino J, Burrone G, Mitra S, Fan TY, English J, Hekman R, Emili A, Lyons SM, Cardamone MD, Perissi V. Inhibition of K63 ubiquitination by G-Protein pathway suppressor 2 (GPS2) regulates mitochondria-associated translation<\/a>. <\/span>Pharmacol Research.<\/strong><\/em> 2024 Sep;207:107336.\u00a0<\/span><\/li>\n
  3. English J<\/span>, Orofino J<\/span>, Cederquist CT<\/span>, Paul I, Li H, Auwerx J, Emili A, Belkina A, Cardamone D<\/span>, Perissi V<\/span>. GPS2-mediated regulation of the adipocyte secretome modulates adipose tissue remodeling at the onset of diet-induced obesity.<\/a> Molecular Metabolism.<\/strong><\/em>\u00a02023 Mar;69:101682<\/span>. <\/span><\/li>\n
  4. Cardamone MD<\/span>, Gao Y<\/span>, Kwan J, Hayashi V<\/span>, Sheeran M<\/span>, Xu J<\/span>, English J<\/span>, Orofino J<\/span>, Emili A, Perissi V<\/span>. Neuralized-like protein 4 (NEURL4) mediates ADP-ribosylation of mitochondrial proteins.<\/a> Journal of Cell Biology<\/em>.<\/strong> 2022 Mar 7;221(3):e202101021.\u00a0<\/span><\/li>\n
  5. Chan S<\/span>, Smith E<\/span>, Gao Y<\/span>, Kwan J, Blum BC, Tilston-Lunel AM, Turcinovic I, Varelas X, Cardamone MC<\/span>, Monti S, Emili A, Perissi V<\/span>. Loss of G-Protein Pathway Suppressor 2 Promotes Tumor Growth Through Activation of AKT Signaling<\/a>. Frontiers Cell and Developmental Biology<\/strong><\/em>, 07 January 2021<\/li>\n
  6. Cardamone MD<\/span>, Orofino J<\/span>, Labadorf A, Perissi V<\/span>. Chromatin Immunoprecipitation of Murine Brown Adipose Tissue.\u00a0<\/a>J Vis Exp<\/span>.<\/strong><\/em>\u00a0Nov 21;(141), 2018<\/li>\n
  7. Cardamone MD<\/span>, Tanasa B*, Cederquist CT<\/span>*, Huang J<\/span>, Mahdaviani K, Li W, Rosenfeld MG, Liesa M, Perissi V<\/span>. \u00a0Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation.<\/a>\u00a0Molecular Cell,<\/span><\/strong><\/em>\u00a069(5):757-772, 2018<\/li>\n
  8. Lentucci<\/span> C<\/span><\/span>, Belkina A*, Cederquist CT<\/span>*, Chan M<\/span>, Johnson HE<\/span>, Prasad S<\/span>, Lopacinski A<\/span>, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD<\/span>, Perissi V<\/span>.\u00a0<\/span>\u00a0Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development.<\/a>\u00a0Journal of Biological Chemistry<\/em><\/strong>, 292(7):2754-2772, 2017<\/li>\n
  9. Cederquist CT<\/span>, Lentucci C<\/span>, Martinez-Calejman C, Hayashi V<\/span>, Orofino J<\/span>, Guertin D, Fried SK, Lee MJ, Cardamone MD<\/span>, Perissi V<\/span>. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue.<\/a>\u00a0Molecular Metabolism<\/em><\/strong>,\u00a06(1):125-137, 2016.<\/li>\n
  10. Huang J<\/span>*, Cardamone MD<\/span>*, Johnson HE<\/span>, Neault M, Chan M<\/span>, Floyd EZ, Mallette FA, Perissi V<\/span>. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation.<\/a>\u00a0Journal of Biological Chemistry<\/em><\/strong>,\u00a0<\/em>290(31):19044-54, 2015<\/li>\n
  11. Cardamone MD<\/span>, Tanasa B, Chan M<\/span>, Cederquist CT<\/span>, Andricovich J<\/span>, Rosenfeld MG, Perissi V<\/span>. GPS2\/KDM4A pioneering activity regulates promoter-specific recruitment of PPAR\u03b3.<\/a>\u00a0Cell Reports,\u00a0<\/em><\/strong>8(1):163-76, 2014<\/li>\n
  12. Cardamone MD<\/span>, Krones A, Tanasa B, Taylor H, Ricci L, Ohgi KA, Glass CK, Rosenfeld MG & Perissi V<\/span>. \u00a0A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2.<\/a>\u00a0\u00a0Molecular Cell<\/i><\/b>, <\/i>46 (1): 91-104, 2012<\/li>\n<\/ol>\n<\/div>\n<\/div>\n

    <\/h4>\n

    Reviews and Editorials<\/strong><\/h4>\n
      \n
    1. Mitro N, Verdeguer F, Perissi V<\/span>. Editorial: Epigenetics and metabolism.<\/a> Front Endocrinol<\/strong><\/em> (Lausanne). 15:1373368, 2024<\/span><\/span><\/li>\n
    2. English J<\/span>, Son JM, Cardamone MD<\/span>, Lee C,\u00a0Perissi V<\/span>. <\/span>Decoding the rosetta stone of mitonuclear communication. <\/a><\/strong><\/em>Pharmacological Research,<\/strong><\/em>\u00a0 Nov;161:105161, 2020<\/span><\/li>\n
    3. Perissi V<\/span>, Jepsen K, Glass CK and Rosenfeld MG. Deconstructing repression: evolving models of co-repressor action.<\/a>\u00a0Nature Reviews Genetics<\/i>,<\/b>\u00a011(2): 109-23, 2010<\/li>\n
    4. Perissi V<\/span> and Rosenfeld MG. Controlling nuclear receptors: the circular logic of cofactor cycles.<\/a>\u00a0\u00a0Nature Reviews Molecular Cell Biology,<\/i><\/b>\u00a06 (7), 542-554, 2005<\/li>\n<\/ol>\n

      <\/h4>\n

      Collaborations<\/h4>\n
        \n
      1. Sepulveda GP, Gushchanskaia ES, Mora-Martin A, Esse R, Nikorich I, Ceballos A, Kwan J, Blum BC, Dholiya P, Emili A, Perissi V<\/span>, Cardamone MD<\/span>, Grishok A. DOT1L stimulates MYC\/Mondo transcription factor activity by promoting its degradation cycle on chromatin<\/a>. bioRxiv<\/strong> [Preprint]. 2024 Feb 7:2024.02.06.579191. doi: 10.1101\/2024.02.06.579191<\/span><\/span><\/span><\/span><\/span><\/li>\n
      2. Oliveira AG, Oliveira LD, Cruz MV, Guimar\u00e3es DSPSF, Lima TI, Santos-F\u00e1vero BC, Luchessi AD, Pauletti BA, Leme AP, Bajgelman MC, Afonso J, Regitano LCA, Carvalho HF, Carneiro EM, Kobarg J, Perissi V<\/span>, Auwerx J, Silveira LR. Interaction between poly(A)-binding protein PABPC4 and nuclear receptor corepressor NCoR1 modulates a metabolic stress response.<\/a> Journal of Biological Chemistry,<\/em><\/strong>\u00a02023 Jun;299(6):104702.\u00a0<\/span><\/span><\/span><\/span><\/span><\/li>\n
      3. Moore J, Ewoldt J, Venturini G, Pereira AC, Padilha K, Lawton M, Lin W, Goel R, Luptak I, Perissi V<\/span>, Seidman CE, Seidman J, Chin MT, Chen C, Emili A. Multi-Omics Profiling of Hypertrophic Cardiomyopathy Reveals Altered Mechanisms in Mitochondrial Dynamics and Excitation-Contraction Coupling<\/a>. Int J Mol Sci.<\/strong><\/em> 2023 Mar 1;24(5):4724.<\/span><\/span><\/span><\/span><\/span><\/li>\n
      4. Hekman RM, Hume AJ, Goel RK, Abo KM, Huang J, Blum BC, Werder RB, Suder EL, Paul I, Phanse S, Youssef A, Alysandratos KD, Padhorny D, Ojha S, Mora-Martin A, Kretov D, Ash PEA, Verma M, Zhao J, Patten JJ, Villacorta-Martin C, Bolzan D, Perea-Resa C, Bullitt E, Hinds A, Tilston-Lunel A, Varelas X, Farhangmehr S, Braunschweig U, Kwan JH, McComb M, Basu A, Saeed M,\u00a0<\/span>Perissi V<\/span>, Burks EJ, Layne MD, Connor JH, Davey R, Cheng JX, Wolozin BL, Blencowe BJ, Wuchty S, Lyons SM, Kozakov D, Cifuentes D, Blower M, Kotton DN, Wilson AA, M\u00fchlberger E, Emili A.<\/span> Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2. <\/a><\/span><\/span><\/span>Molecular Cell,<\/strong><\/em>\u00a0 Jan 7;81(1):212, 2021<\/li>\n
      5. Jones JEC, Rabhi N, Orofino J<\/span>, Gamini R, Perissi V<\/span>, Vernochet C, Farmer SR. <\/span>The Adipocyte Acquires a Fibroblast-Like Transcriptional Signature in Response to a High Fat Diet.\u00a0<\/a>Scientific Reports,<\/strong><\/em> Feb 11;10(1):2380, 2020<\/span><\/li>\n
      6. Lima TI, Guimar\u00e3es DSPSF, Oliveira AG, Araujo H, Sponton CHG, Souza-Pinto NC, Saito \u00c2, Figueira ACM, Palameta S, Bajgelman MC, Calixto A, Pinto S, Mori M.A, Orofino J<\/span>, Perissi V<\/span>, Mottis A, Auwerx J, Silveira LR. Opposing action of NCoR1 and PGC-1\u03b1 in mitochondrial redox homeostasis.\u00a0<\/a>Free Radic Biol Med.<\/strong><\/em> Nov 1;143:203-208, 2019<\/li>\n
      7. Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Gr\u00fcnewald A, Rygiel KA, Rocha MC, Reeve AK, Falkous G, Perissi V<\/span>, White K, Davey T, Petrof BJ, Sayer AA, Cooper C, Deehan D, Taylor RW, Turnbull DM, Picard M. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle.\u00a0<\/a>Annals of Neurology,<\/span><\/strong><\/em> Aug;84(2):289-301, 2018<\/li>\n
      8. Mahdaviani K, Benador IY, Su S, Gharakhanian RA, Stiles L, Trudeau KM, Cardamone MD<\/span>, Enr\u00edquez-Zarralanga V, Ritou E,. Aprahamian T, Oliveira MF, Corkey BE, Perissi V<\/span>, Liesa M, Shirihai OS. Mfn2 deletion in brown adipose tissue protects from insulin resistance and impairs thermogenesis.<\/a> \u00a0EMBO Reports,<\/span><\/strong><\/em>\u00a018(7):1123-1138, 2017.<\/li>\n<\/ol>\n

        Other Relevant Publications<\/h4>\n
          \n
        1. Scafoglio C, Smolka M, Zhou H, Perissi V<\/span>, Rosenfeld MG. The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation.<\/a>\u00a0PLOS One<\/em><\/strong> 8 (5): e59986, 2013<\/li>\n
        2. Perissi V<\/span>, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG. TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR\/SMRT transcriptional repression checkpoints.<\/a>\u00a0\u00a0Molecular Cell<\/i><\/b>, <\/i>29 (6), 755-66, 2008<\/li>\n
        3. Perissi V<\/span>, Aggarwal A, Glass CK, Rose DW, Rosenfeld MG. A corepressor\/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors.<\/a>\u00a0\u00a0<\/i>Cell,<\/i><\/b> <\/i>116(4): 511-26, 2004<\/li>\n
        4. Li X, Perissi V<\/span>, Liu F, Rose DW, Rosenfeld MG. Tissue-specific regulation of retinal and pituitary precursor cell proliferation.<\/a>\u00a0Science<\/em><\/strong>,<\/em> 16(5584):1180-3, 2002<\/li>\n
        5. Wen YD, Perissi V<\/span>, Staszewski LM, Yang WM, Krones A, Glass CK, Rosenfeld MG, Seto E. The histone deacetylase-3 complex contains nuclear receptor corepressors.<\/a>\u00a0PNAS<\/em><\/strong>, <\/em>97(13), 7202-7207, 2000<\/li>\n
        6. Perissi V<\/span>, Menini N, Cottone E, Capello D, Sacco M, Montaldo F, De Bortoli M. AP-2 transcription factors in the regulation of ERBB2 gene transcription by oestrogen.<\/a>\u00a0Oncogene,<\/em><\/strong> 19 (2), 280-288, 2000<\/li>\n
        7. Perissi V<\/span>, Staszewski LM, McInerney EM, Kurokawa R, Krones A, Rose DW, Lambert MH, Milburn MV, Glass CK, Rosenfeld MG. \u00a0Molecular determinants of nuclear receptor-corepressor interaction.<\/a> \u00a0Genes&Development<\/i><\/b>, <\/i>13 (24), 3198-3208, 1999<\/li>\n
        8. Perissi V<\/span>, Dasen JS, Kurokawa R, Wang Z, Korzus E, Rose DW, Glass CK, Rosenfeld MG. Factor-specific modulation of CREB-binding protein acetyltransferase activity.<\/a>\u00a0PNAS,<\/em><\/strong> 96(7), 3652-3657, 1999<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

          Most Recent Lab Publications Ferrero G, Cardamone MD, Luca F, Bourk E, Ricci L, Liu W, Gao Y, Burrone G, Muhammad A, Chan S, Smith E, Fan TC, Cutrupi S, Garcia-Bassets I, De Bortoli M, Rosenfeld MG, Perissi V. Nonproteolytic ubiquitination regulates chromatin occupancy by the NCoR\/SMRT\/HDAC3 corepressor complex in MCF-7 breast cancer cells. Proc […]<\/p>\n","protected":false},"author":16087,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"open","ping_status":"open","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/perissilab\/wp-json\/wp\/v2\/pages\/491"}],"collection":[{"href":"https:\/\/sites.bu.edu\/perissilab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/perissilab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/perissilab\/wp-json\/wp\/v2\/users\/16087"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/perissilab\/wp-json\/wp\/v2\/comments?post=491"}],"version-history":[{"count":23,"href":"https:\/\/sites.bu.edu\/perissilab\/wp-json\/wp\/v2\/pages\/491\/revisions"}],"predecessor-version":[{"id":903,"href":"https:\/\/sites.bu.edu\/perissilab\/wp-json\/wp\/v2\/pages\/491\/revisions\/903"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/perissilab\/wp-json\/wp\/v2\/media?parent=491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}