{"id":7541,"date":"2016-04-08T12:36:41","date_gmt":"2016-04-08T16:36:41","guid":{"rendered":"https:\/\/sites.bu.edu\/ombs\/?p=7541"},"modified":"2016-04-08T12:36:41","modified_gmt":"2016-04-08T16:36:41","slug":"new-advances-in-drug-therapy-crossing-the-blood-brain-barrier","status":"publish","type":"post","link":"https:\/\/sites.bu.edu\/ombs\/2016\/04\/08\/new-advances-in-drug-therapy-crossing-the-blood-brain-barrier\/","title":{"rendered":"New Advances in Drug Therapy: Crossing the Blood Brain Barrier"},"content":{"rendered":"<p><a href=\"\/ombs\/files\/2016\/04\/bbbcart.gif\"><img loading=\"lazy\" src=\"\/ombs\/files\/2016\/04\/bbbcart.gif\" alt=\"bbbcart\" width=\"338\" height=\"175\" class=\" size-full wp-image-7542 aligncenter\" \/><\/a><\/p>\n<p>Recent research has discovered new ways to deliver drugs to the brain through the blood brain barrier. This blood brain barrier is created by specialized cells that safeguard the brain from unwanted substances. Cornell researchers were able to create a drug called Lexiscan, which activates receptors that are on the blood brain barrier. Their goal in developing this drug was to open the barrier for a brief amount of time, just enough to deliver the pharmacological treatment to the brain in order to treat neurological disorders. They were able to make headway by delivering chemotherapy drugs into the brains of mice with Lexiscan and then having the antibodies bind onto the Amyloid-<span>\u03b2<\/span> plaques present in Alzheimer\u2019s disease. This new breakthrough shows not only a new development in the pharmaceutical industry, but a new approach to treat diseases that would otherwise be left untreated because of the inability of other therapies to pass through the blood brain barrier. Diseases such as Alzheimer\u2019s, Parkinson\u2019s, autism, and brain tumors that were otherwise unable to be treated with drug therapy, all have a new potential to be cured as drugs are now able to cross the blood brain barrier.<\/p>\n<p>~Albert Wang<\/p>\n<p>Sources:<\/p>\n<p><span><a href=\"http:\/\/neurosciencenews.com\/blood-brain-barrier-drug-delivery-3976\/\">Opening the Blood-Brain Barrier to Deliver Drugs For Brain Diseases<\/a><\/span><\/p>\n<p><span><a href=\"https:\/\/www.jci.org\/articles\/view\/76207\">A2A Adenosine Receptor Modulates Drug Efflux Transporter P-Glycoprotein at the Blood-Brain Barrier<\/a><\/span><\/p>\n<p>Image Source:<\/p>\n<p><span><a href=\"https:\/\/faculty.washington.edu\/chudler\/gif\/bbbcart.gif\">Neuroscience For Kids<\/a><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Recent research has discovered new ways to deliver drugs to the brain through the blood brain barrier. This blood brain barrier is created by specialized cells that safeguard the brain from unwanted substances. Cornell researchers were able to create a drug called Lexiscan, which activates receptors that are on the blood brain barrier. Their goal [&hellip;]<\/p>\n","protected":false},"author":9559,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/posts\/7541"}],"collection":[{"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/users\/9559"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/comments?post=7541"}],"version-history":[{"count":1,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/posts\/7541\/revisions"}],"predecessor-version":[{"id":7543,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/posts\/7541\/revisions\/7543"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/media?parent=7541"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/categories?post=7541"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/tags?post=7541"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}