{"id":1223,"date":"2010-11-30T13:52:12","date_gmt":"2010-11-30T17:52:12","guid":{"rendered":"http:\/\/blogs.bu.edu\/ombs\/?p=1223"},"modified":"2010-11-30T13:52:12","modified_gmt":"2010-11-30T17:52:12","slug":"knocking-out-parkinsons-disease","status":"publish","type":"post","link":"https:\/\/sites.bu.edu\/ombs\/2010\/11\/30\/knocking-out-parkinsons-disease\/","title":{"rendered":"Knocking Out Parkinson&#039;s Disease"},"content":{"rendered":"<p><a class=\"addthis_button\" href=\"http:\/\/www.addthis.com\/bookmark.php?v=250&amp;username=xa-4bb6bcc8320e5dd9\"><img loading=\"lazy\" src=\"http:\/\/s7.addthis.com\/static\/btn\/v2\/lg-share-en.gif\" alt=\"Bookmark and Share\" width=\"125\" height=\"16\" \/><\/a><script src=\"http:\/\/s7.addthis.com\/js\/250\/addthis_widget.js#username=xa-4bb6bcc8320e5dd9\" type=\"text\/javascript\"><\/script><\/p>\n<p>Parkinson&#8217;s disease is one of the most infamous neurological disorders known to medicine and has afflicted many, including Muhammed Ali and Michael J. Fox. \u00a0Described by it&#8217;s characteristic tremors and shaking, the disease induces loss of control of motor function as a result of neuronal death in dopamine-releasing (dopaminergic) neurons in a midbrain structure called the substantia nigra. In the pathology of Parkinson&#8217;s Disease, this localized population of dopaminergic neurons start to die, while other neurons in the substantia nigra and other local dopaminergic neurons remain healthy and functional. This has puzzled researchers extensively, but a recent letter to Nature provides some breakthroughs in understanding what is happening in these degenerative neurons.<\/p>\n<figure id=\"attachment_1230\" aria-describedby=\"caption-attachment-1230\" style=\"width: 250px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" class=\"size-full wp-image-1230 \" src=\"https:\/\/sites.bu.edu\/ombs\/files\/2010\/11\/parkinsons-celebrity.jpg\" alt=\"Muhammed Ali and Michael J. Fox are two celebrities battling Parkinson's Disease.\" width=\"240\" height=\"181\" \/><figcaption id=\"caption-attachment-1230\" class=\"wp-caption-text\">Muhammed Ali and Michael J. Fox are two celebrities battling Parkinson&#039;s Disease.<\/figcaption><\/figure>\n<p>Recent research into Parkinson&#8217;s suggests that the problems are localized to the mitochondria of the suspect neurons, leading to the conclusion that the disease is related to problems with metabolism. The mitochondria are the machines of cell metabolism and the stage for the Kreb&#8217;s Cycle and the Electron Transport Chain (ETC), which are the two major energy producing processes of the cell. The metabolism occurring in the mitochondria produces large amounts of adenosine triphosphate (ATP) which is used as energy currency in all cells of the body, and also lead to the production of water to be used elsewhere by the cell. Oxidative stress in the water producing portion of the metabolic pathway can lead to the production of oxygen free radicals, which are highly reactive as a result of a single free electron (free radicals have implications in other degenerative disorders and cancer). Scientists now suspect that these free radicals are contributing to the neurodegenerative consequences of Parkinson&#8217;s Disease.<\/p>\n<figure id=\"attachment_1231\" aria-describedby=\"caption-attachment-1231\" style=\"width: 262px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" class=\"size-medium wp-image-1231 \" src=\"https:\/\/sites.bu.edu\/ombs\/files\/2010\/11\/Brainpet-300x192.gif\" alt=\"Brainpet\" width=\"252\" height=\"161\" srcset=\"https:\/\/sites.bu.edu\/ombs\/files\/2010\/11\/Brainpet-300x192.gif 300w, https:\/\/sites.bu.edu\/ombs\/files\/2010\/11\/Brainpet.gif 419w\" sizes=\"(max-width: 252px) 100vw, 252px\" \/><figcaption id=\"caption-attachment-1231\" class=\"wp-caption-text\">Neuroimaging study showing the decreased neuronal activity in Parkinson&#039;s Disease.<\/figcaption><\/figure>\n<p>In the Nature study, scientists tagged the mitochondria of the Parkinson&#8217;s suspect neurons with fluorescent protein that would allow them to observe oxidation states of the cells in rats. They found that Parkinson&#8217;s cells were in fact under a high level of oxidative stress and showed stress patterns at regular intervals, concluding that the cells function rhythmically when releasing dopamine. This rhythmic function is associated with ATP driven increases of calcium levels in the neurons, and the study suggests that this rhythmic calcium fluctuation is the instigator of the oxidative stress associated with Parkinson&#8217;s disease. In further experimentation, the researchers blocked these calcium influxes with drugs, which led to a decrease in Parkinson&#8217;s-like oxidative stress \u00a0in mouse models of early-onset Parkinson&#8217;s disease. These drugs are known to be tolerated by humans well, and provide a legitimate option for medicinal therapy in the disease.<\/p>\n<p><span style=\"font-family: Georgia;line-height: 11px;font-size: x-small;color: #222222\"><a href=\"http:\/\/www.nature.com\/nature\/journal\/vaop\/ncurrent\/full\/nature09536.html\"><span style=\"font-weight: normal\"><span style=\"font-family: Georgia;font-size: small\"><span>Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1<\/span><\/span><\/span><\/a><span style=\"font-weight: normal\"><span style=\"font-family: Georgia;font-size: small\"><span> &#8211; Nature 2010<\/span><\/span><\/span><\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Parkinson&#8217;s disease is one of the most infamous neurological disorders known to medicine and has afflicted many, including Muhammed Ali and Michael J. Fox. \u00a0Described by it&#8217;s characteristic tremors and shaking, the disease induces loss of control of motor function as a result of neuronal death in dopamine-releasing (dopaminergic) neurons in a midbrain structure called [&hellip;]<\/p>\n","protected":false},"author":4993,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/posts\/1223"}],"collection":[{"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/users\/4993"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/comments?post=1223"}],"version-history":[{"count":0,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/posts\/1223\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/media?parent=1223"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/categories?post=1223"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sites.bu.edu\/ombs\/wp-json\/wp\/v2\/tags?post=1223"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}