{"id":213,"date":"2020-04-01T09:05:52","date_gmt":"2020-04-01T13:05:52","guid":{"rendered":"https:\/\/sites.bu.edu\/nil\/?page_id=213"},"modified":"2022-07-12T18:51:06","modified_gmt":"2022-07-12T22:51:06","slug":"projects","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/nil\/projects\/","title":{"rendered":"Projects"},"content":{"rendered":"<h3 style=\"text-align: center;\">Stem cell imaging<\/h3>\n<div class=\"bu-slideshow-container stem autoplay\" id=\"bu-slideshow-container-215\" data-slideshow-name=\"stem\" data-slideshow-delay=\"4000\" style=\"width: 300px; height: 100px;; margin-left: auto; margin-right: auto;\"><div class='slideshow-loader active'><div class='loader-animation'><\/div><p>loading slideshow...<\/p><\/div><div class=\"bu-slideshow-slides\"><ul class=\"bu-slideshow transition-fade\" id=\"bu-slideshow-215\"><li id=\"bu-slideshow-215_0\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Stem4-636x475.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-215_1\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Stem6.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-215_2\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Stem1-636x477.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-215_3\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Stem2-636x477.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-215_4\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Stem5.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-215_5\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Stem3-636x477.jpg\" alt=\"\" \/><\/div><\/li><\/ul><\/div><\/div>\n<table style=\"width: 700px;\" border=\"0\">\n<tbody>\n<tr valign=\"top\">\n<td style=\"width: 150px; text-align: center;\">Leading investigator<br \/>\n<img loading=\"lazy\" src=\"\/nil\/files\/2020\/03\/Francesca.jpg\" alt=\"\" width=\"636\" height=\"636\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\nDr. Francesca Puppo<\/td>\n<td style=\"width: 550px;\">Traditionally, neuronal electrical properties have been evaluated using intracellular electrophysiology, which is low-throughput and labor intensive. Recent advances in optical microscopy and optogenetics offer a new experimental paradigm \u2013 \u201call-optical electrophysiology\u201d \u2013 where optical voltage sensors and optogenetic actuators are combined for all optical stimulation and readout. Applied to human-induced pluripotent stem cells, all-optical electrophysiology opens unprecedented opportunities for high-throughput phenotyping of neurons and neuronal networks possessing unique genetic background of individual patients.<\/p>\n<p>Contact <strong><em>Dr. Francesca Puppo<\/em><\/strong> at <a href=\"mailto:fpuppo@health.ucsd.edu\">fpuppo@health.ucsd.edu<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Meet our collaborators:<\/p>\n<table style=\"width: 700px;\" border=\"0\">\n<tbody>\n<tr valign=\"top\">\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Alysson1.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-full wp-image-150\" \/><br \/>\n<a href=\"https:\/\/medschool.ucsd.edu\/som\/pediatrics\/research\/labs\/muotri-lab\/Pages\/default.aspx\">Dr. Alysson Muotri<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\">\u00a0<img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Ole1.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\n<a href=\"https:\/\/www.med.uio.no\/klinmed\/english\/people\/aca\/olean\/\">Dr. Ole Andreassen<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Srdjan1.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-full wp-image-150\" \/><br \/>\n<a href=\"https:\/\/www.med.uio.no\/norment\/personer\/ledelse\/djurovic\/\">Dr. Srdjan Djurovic<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h3 style=\"text-align: center;\">Oxygen imaging<\/h3>\n<div class=\"bu-slideshow-container po2 autoplay\" id=\"bu-slideshow-container-288\" data-slideshow-name=\"po2\" data-slideshow-delay=\"4000\" style=\"width: 200px; ; margin-left: auto; margin-right: auto;\"><div class='slideshow-loader active'><div class='loader-animation'><\/div><p>loading slideshow...<\/p><\/div><div class=\"bu-slideshow-slides\"><ul class=\"bu-slideshow transition-fade\" id=\"bu-slideshow-288\"><li id=\"bu-slideshow-288_0\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Ox3-636x636.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-288_1\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Ox5-636x636.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-288_2\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Ox4-636x636.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-288_3\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Ox2-636x636.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-288_4\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/Ox1-636x636.jpg\" alt=\"\" \/><\/div><\/li><\/ul><\/div><\/div>\n<table style=\"width: 700px;\" border=\"0\">\n<tbody>\n<tr valign=\"top\">\n<td style=\"width: 150px; text-align: center;\">Leading co-investigator<br \/>\n<img loading=\"lazy\" src=\"\/nil\/files\/2020\/03\/Natalie.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-full wp-image-150\" \/><br \/>\nDr. Natalie Fomin<\/td>\n<td style=\"width: 150px; text-align: center;\">Leading co-investigator<br \/>\n<img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Philipp2.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\nDr. Philipp M\u00e4chler<\/td>\n<td style=\"width: 400px;\">Recently, our ability to measure O2 with microscopic resolution has been revolutionized by the arrival of specific optical probes excitable in the two-photon regime and the development of two-photon phosphorescence lifetime microscopy (2PLM). 2PLM allows measurement of both intravascular and tissue partial pressure of O2 (pO2) with unprecedented spatial resolution and is well suited to imaging of pO2 changes at the baseline as well as during functional activation. 2PLM also offers a novel method for quantitation of CMRO2 based on pO2 gradients immediately surrounding diving arterioles.<\/p>\n<p>Contact <strong><em>Dr. Natalie Fomin-Thunemann<\/em><\/strong> at <a href=\"mailto:n.fomin87@gmail.com\">n.fomin87@gmail.com<\/a> or <strong><em>Dr. Philipp M\u00e4chler<\/em><\/strong> at <a href=\"philipp.maechler@outlook.com\">philipp.maechler@outlook.com<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Meet our collaborators:<\/p>\n<table style=\"width: 700px;\" border=\"0\">\n<tbody>\n<tr valign=\"top\">\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Sava.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\n<a href=\"https:\/\/www.nmr.mgh.harvard.edu\/user\/7028\">Dr. Sava Sakadzic<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/David.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\n<a href=\"https:\/\/www.bu.edu\/eng\/profile\/david-boas-ph-d\/\">Dr. David Boas<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Sergei.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\n<a href=\"https:\/\/www.med.upenn.edu\/apps\/faculty\/index.php\/g20\/p11726\">Dr. Sergei Vinogradov<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Anders.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\n<a href=\"https:\/\/profiles.ucsd.edu\/anders.dale\">Dr. Anders Dale<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h3 style=\"text-align: center;\">Awake mouse fMRI<\/h3>\n<div class=\"bu-slideshow-container mri autoplay\" id=\"bu-slideshow-container-427\" data-slideshow-name=\"mri\" data-slideshow-delay=\"4000\" style=\"width: 200px; ; margin-left: auto; margin-right: auto;\"><div class='slideshow-loader active'><div class='loader-animation'><\/div><p>loading slideshow...<\/p><\/div><div class=\"bu-slideshow-slides\"><ul class=\"bu-slideshow transition-fade\" id=\"bu-slideshow-427\"><li id=\"bu-slideshow-427_0\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/MR2.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-427_1\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/MR3.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-427_2\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/MR4.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-427_3\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/MR5.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-427_4\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2020\/04\/MR6-636x636.jpg\" alt=\"\" \/><\/div><\/li><\/ul><\/div><\/div>\n<table style=\"width: 700px;\" border=\"0\">\n<tbody>\n<tr valign=\"top\">\n<td style=\"width: 150px; text-align: center;\">Leading co-investigator<br \/>\n<img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Philipp2.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-full wp-image-150\" \/><br \/>\nPatrick Doran<\/td>\n<td style=\"width: 150px; text-align: center;\">Leading co-investigator<br \/>\n<img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Patrick2.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\nPatrick Doran<\/td>\n<td style=\"width: 400px;\">Noninvasive imaging technologies such as fMRI are widely used to investigate the function of the human brain. However, interpretation of these macroscopic signals in terms of the underlying microscopic physiology, such as electrical activity of single neurons and hemodynamic activity of single blood vessels, is still under investigation. Noninvasive imaging in animals can play a critical role in physiological underpinning and data-driven modeling of human noninvasive signals, in particular when both micro- and macroscopic measurements are achieved in the same subject under analogous experimental conditions. To this end, we perform fMRI in awake mice implanted with chronic glass windows that provide optical access for micro- and \u201cmesoscopic\u201d optical imaging as well as for photostimulation.<\/p>\n<p>Contact <strong><em>Dr. Philipp M\u00e4chler<\/em><\/strong> at <a href=\"philipp.maechler@outlook.com\">philipp.maechler@outlook.com<\/a> or <strong><em>Patrick Doran<\/em><\/strong> at <a href=\"mailto:pdoran@bu.edu\">pdoran@bu.edu<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Meet our collaborators:<\/p>\n<table style=\"width: 700px;\" border=\"0\">\n<tbody>\n<tr valign=\"top\">\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Sava.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-294\" srcset=\"https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava.jpg 2448w, https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava-150x150.jpg 150w, https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava-636x636.jpg 636w, https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava-768x768.jpg 768w, https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava-1024x1024.jpg 1024w, https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava-100x100.jpg 100w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/><br \/>\n<a href=\"https:\/\/www.nmr.mgh.harvard.edu\/user\/7028\">Dr. Sava Sakadzic<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Michele2.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-294\" \/><br \/>\n<a href=\"http:\/\/www.crchudequebec.ulaval.ca\/en\/research\/researchers\/michele-desjardins\/\">Dr. Mich\u00e8le Desjardins<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Joe.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-294\" \/><br \/>\n<a href=\"https:\/\/www.nmr.mgh.harvard.edu\/user\/5236\">Dr. Joe Mandeville<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Rick.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-294\" \/><br \/>\n<a href=\"https:\/\/cfmriweb.ucsd.edu\/Research\/Faculty\/rbuxton.html\">Dr. Rick Buxton<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h3 style=\"text-align: center;\">Cell-type-specific neurovascular coupling<\/h3>\n<div class=\"bu-slideshow-container nvc autoplay\" id=\"bu-slideshow-container-572\" data-slideshow-name=\"nvc\" data-slideshow-delay=\"4000\" style=\"width: 200px; ; margin-left: auto; margin-right: auto;\"><div class='slideshow-loader active'><div class='loader-animation'><\/div><p>loading slideshow...<\/p><\/div><div class=\"bu-slideshow-slides\"><ul class=\"bu-slideshow transition-fade\" id=\"bu-slideshow-572\"><li id=\"bu-slideshow-572_0\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2022\/07\/NVC1.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-572_1\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2022\/07\/NVC3-636x636.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-572_2\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2022\/07\/NVC2-636x636.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-572_3\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/nil\/files\/2022\/07\/NVC4-636x636.jpg\" alt=\"\" \/><\/div><\/li><\/ul><\/div><\/div>\n<table style=\"width: 700px;\" border=\"0\">\n<tbody>\n<tr valign=\"top\">\n<td style=\"width: 150px; text-align: center;\">Leading investigator<br \/>\n<img loading=\"lazy\" src=\"\/nil\/files\/2020\/03\/Martin.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\nDr. Martin Thunemann<\/td>\n<td style=\"width: 550px;\">Identification of the cellular players and molecular messengers that communicate neuronal activity to the vasculature driving cerebral hemodynamics is important for the basic understanding of cerebrovascular regulation and for interpretation of fMRI signals. A growing body of experimental evidence indicates that an increase in cerebral blood flow in response to increased neuronal activity (a.k.a. \u201cfunctional hyperemia\u201d) under healthy conditions is largely driven by vasoactive messengers related to neuronal signaling. We combine two-photon single-vessel measurements of vasodilation with optogenetic stimulation to study neurovascular regulation with high level of specificity and microscopic resolution.<\/p>\n<p>Contact <strong><em>Dr. Martin Thunemann<\/em><\/strong> at <a href=\"mailto:martin@thunemann.de\">martin@thunemann.de<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>Meet our collaborators:<\/p>\n<table style=\"width: 700px;\" border=\"0\">\n<tbody>\n<tr valign=\"top\">\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/DavidK2.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\n<a href=\"https:\/\/neurophysics.ucsd.edu\/\">Dr. David Kleinfeld<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/07\/MartinLauritzen.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\n<a href=\"https:\/\/in.ku.dk\/research\/martin-lauritzen\/\">Dr. Martin Lauritzen<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/Sava.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-294\" srcset=\"https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava.jpg 2448w, https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava-150x150.jpg 150w, https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava-636x636.jpg 636w, https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava-768x768.jpg 768w, https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava-1024x1024.jpg 1024w, https:\/\/sites.bu.edu\/nil\/files\/2020\/04\/Sava-100x100.jpg 100w\" sizes=\"(max-width: 150px) 100vw, 150px\" \/><br \/>\n<a href=\"https:\/\/www.nmr.mgh.harvard.edu\/user\/7028\">Dr. Sava Sakadzic<\/a><\/td>\n<td style=\"width: 150px; text-align: center;\"><img loading=\"lazy\" src=\"\/nil\/files\/2020\/04\/David.jpg\" alt=\"\" width=\"150\" height=\"150\" class=\"alignnone size-medium wp-image-150\" \/><br \/>\n<a href=\"https:\/\/www.bu.edu\/eng\/profile\/david-boas-ph-d\/\">Dr. David Boas<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Stem cell imaging Leading investigator Dr. Francesca Puppo Traditionally, neuronal electrical properties have been evaluated using intracellular electrophysiology, which is low-throughput and labor intensive. Recent advances in optical microscopy and optogenetics offer a new experimental paradigm \u2013 \u201call-optical electrophysiology\u201d \u2013 where optical voltage sensors and optogenetic actuators are combined for all optical stimulation and readout. [&hellip;]<\/p>\n","protected":false},"author":17613,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/nil\/wp-json\/wp\/v2\/pages\/213"}],"collection":[{"href":"https:\/\/sites.bu.edu\/nil\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/nil\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/nil\/wp-json\/wp\/v2\/users\/17613"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/nil\/wp-json\/wp\/v2\/comments?post=213"}],"version-history":[{"count":41,"href":"https:\/\/sites.bu.edu\/nil\/wp-json\/wp\/v2\/pages\/213\/revisions"}],"predecessor-version":[{"id":575,"href":"https:\/\/sites.bu.edu\/nil\/wp-json\/wp\/v2\/pages\/213\/revisions\/575"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/nil\/wp-json\/wp\/v2\/media?parent=213"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}