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Molecular rhythm alterations in prefrontal cortex and nucleus accumbens associated with opioid use disorder

Consideration of genetic and sex effects in mice enhances consilience with human addiction studies

Peer Reviewed

Vadnie CA, Petersen KA, Eberhardt LA, Hildebrand MA, Cerwensky AJ, Zhang H, Burns JN, Becker-Krail DD, DePoy LM, Logan RW, McClung CA. The suprachiasmatic nucleus regulates anxiety-like behavior in mice. Front. Neurosci. 2022 Jan 20. https://doi.org/10.3389/fnins.2021.765850. Online ahead of print. PMID: XXXX. PDF

Becker-Krail DD, Parekh PK, Ketchesin KD, Yamaguchi S, Yoshino J, Hildebrand MA, Dunham B, Ganapathiraiu MK, Logan RW, McClung CA. Circadian transcription factor NPAS2 and the NAD+ dependent deacetylase SIRT1 interact in the mouse nucleus accumbens and regulate reward. Eur J Neurosci. 2022 Jan 9. doi: 10.1111/ejn.15596. Online ahead of print.PMID: 35001440. PDF

Borrelli K, Yao E, Yen W, Phadke R, Ruan Q, Chen M, Kelliher J, Langan C, Scotellaro J, Babbs R, Beierle J, Logan RW, Johnson W, Wachman E, Cruz-Martin A, Bryant CD. Sex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice. eNeuro. 2021 Sep 20;8(5):ENEURO.0143-21.2021. doi: 10.1523/ENEURO.0143-21.2021. Print 2021 Sep-Oct.PMID: 34479978. PDF

Seney ML, Kim SM, Glausier JR, Hildebrand MA, Xue X, Zong W, Wang J, Shelton MA, Phan BN, Srinivasan C, Pfenning AR, Tseng GC, Lewis DA, Freyberg Z, Logan RW. Transcriptional alterations in opioid use disorder reveal an interplay between neuroinflammation and synaptic remodeling. Biological Psychiatry. 2021. Jun 12:S0006-3223(21)01369-X. doi: 10.1016/j.biopsych.2021.06.007. Online ahead of print. PubMed PMID: 34380600. PDF

Logan R.W., Xue X., Ketchesin K.D., Hoffman G., Roussos P., Tseng G., McClung C.A. & Seney M.L., Sex differences in molecular rhythms in the human cortex, Biological Psychiatry. 2021. doi: https://doi.org/10.1016/j.biopsych.2021.03.005. PubMed PMID: 33934884. PDF

Buck SA, Steinkellner T, Aslanoglou D, Villeneuve M, Bhatte SH, Childers VC, Rubin SA, De Miranda BR, O’Leary EI, Neureiter EG, Fogle KJ, Palladino MJ, Logan RW, Glausier JR, Fish KN, Lewis DA, Greenamyre JT, McCabe BD, Cheetham CEJ, Hnasko TS, Freyberg Z. Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration. Aging Cell. 2021, May 20(5):e13365. doi: 10.1111/acel.13365. PubMed PMID: 33909313. PDF

Hasler BP, Soehner AM, Wallace ML, Logan RW, Ngari W, Forbes EE, Buysse DJ, Clark DB. Experimentally imposed circadian misalignment alters the neural response to monetary rewards and response inhibition in healthy adolescents. Psychol Med. 2021, Mar 17;1-9. doing: 10/1017/S0033291721000787. PMID: 33729109. PDF

Aslanoglou D, Bertera S, Sánchez-Soto M, Benjamin Free R, Lee J, Zong W, Xue X, Shrestha S, Brissova M, Logan RW, Wollheim CB, Trucco M, Yechoor VK, Sibley DR, Bottino R, Freyberg Z. Dopamine regulates pancreatic glucagon and insulin secretion via adrenergic and dopaminergic receptors. Transl Psychiatry. 2021 Feb 16;11(1):59. doi: 10.1038/s41398-020-01171-z. PMID: 33589583; PMCID: PMC7884786. PDF

Kim SM, Vadnie CA, Philip VM, Gagnon LH, Chowdari KV, Chesler EJ, McClung CA, Logan RW. High-throughput measurement of fibroblast rhythms reveals genetic heritability of circadian phenotypes in diversity outbred mice and their founder strains. Sci Rep. 2021 Jan 28;11(1):2573. doi: 10.1038/s41598-021-82069-8. PMID: 33510298; PMCID: PMC7843998. PDF

Prestwood TR, Asgariroozbehani R, Wu S, Agarwal SM, Logan RW, Ballon JS, Hahn MK, Freyberg Z. Roles of inflammation in intrinsic pathophysiology and antipsychotic drug-induced metabolic disturbances of schizophrenia. Behav Brain Res. 2021 Mar 26;402:113101. doi: 10.1016/j.bbr.2020.113101. Epub 2021 Jan 14. PMID: 33453341; PMCID: PMC7882027. PDF

DePoy LM, Becker-Krail DD, Zong W, Petersen K, Shah NM, Brandon JH, Miguelino AM, Tseng GC, Logan RW, McClung CA. Circadian-Dependent and Sex-Dependent Increases in Intravenous Cocaine Self-Administration in Npas2 Mutant Mice. J Neurosci. 2021 Feb 3;41(5):1046-1058. doi: 10.1523/JNEUROSCI.1830-20.2020. Epub 2020 Dec 2. PMID: 33268545; PMCID: PMC7880289. PDF

Logan RW, Ozburn AR, Arey RN, Ketchesin KD, Winquist A, Crain A, Tobe BTD, Becker-Krail D, Jarpe MB, Xue X, Zong W, Huo Z, Parekh PK, Zhu X, Fitzgerald E, Zhang H, Oliver-Smith J, DePoy LM, Hildebrand MA, Snyder EY, Tseng GC, McClung CA. Valproate reverses mania-like behaviors in mice via preferential targeting of HDAC2. Mol Psychiatry. 2020 Nov 24. doi: 10.1038/s41380-020-00958-2. Epub ahead of print. PMID: 33235333. PDF

Seney ML, Logan RW. Critical roles for developmental hormones and genetic sex in stress-induced transcriptional changes associated with depression. Neuropsychopharmacology. 2021 Jan;46(1):221-222. doi: 10.1038/s41386-020-00792-8. PMID: 32770141; PMCID: PMC7689456. PDF

Buck SA, Torregrossa MM, Logan RW, Freyberg Z. Roles of dopamine and glutamate co-release in the nucleus accumbens in mediating the actions of drugs of abuse. FEBS J. 2021 Mar;288(5):1462-1474. doi: 10.1111/febs.15496. Epub 2020 Aug 11. PMID: 32702182; PMCID: PMC7854787. PDF

Maroni MJ, Capri KM, Arruda NL, Gelineau RR, Deane HV, Concepcion HA, DeCourcey H, Monteiro De Pina IK, Cushman AV, Chasse MH, Logan RW, Seggio JA. Substrain specific behavioral responses in male C57BL/6N and C57BL/6J mice to a shortened 21-hour day and high-fat diet. Chronobiol Int. 2020 Jun;37(6):809-823. doi: 10.1080/07420528.2020.1756840. Epub 2020 May 13. PMID: 32400203; PMCID: PMC7758871. PDF

Paden W, Barko K, Puralewski R, Cahill KM, Huo Z, Shelton MA, Tseng GC, Logan RW, Seney ML. Sex differences in adult mood and in stress-induced transcriptional coherence across mesocorticolimbic circuitry. Transl Psychiatry. 2020 Feb 6;10(1):59. doi: 10.1038/s41398-020-0742-9. PMID: 32066699; PMCID: PMC7026087. PDF

Datta U, Schoenrock SE, Bubier JA, Bogue MA, Jentsch JD, Logan RW, Tarantino LM, Chesler EJ. Prospects for finding the mechanisms of sex differences in addiction with human and model organism genetic analysis. Genes Brain Behav. 2020 Mar;19(3):e12645. doi: 10.1111/gbb.12645. Epub 2020 Feb 11. PMID: 32012419; PMCID: PMC7060801. PDF

Capri KM, Maroni MJ, Deane HV, Concepcion HA, DeCourcey H, Logan RW, Seggio JA. Male C57BL6/N and C57BL6/J Mice Respond Differently to Constant Light and Running-Wheel Access. Front Behav Neurosci. 2019 Dec 10;13:268. doi: 10.3389/fnbeh.2019.00268. PMID: 31920578; PMCID: PMC6914853. PDF

Schoenrock SA, Kumar P, Gómez-A A, Dickson PE, Kim SM, Bailey L, Neira S, Riker KD, Farrington J, Gaines CH, Khan S, Wilcox TD, Roy TA, Leonardo MR, Olson AA, Gagnon LH, Philip VM, Valdar W, de Villena FP, Jentsch JD, Logan RW, McClung CA, Robinson DL, Chesler EJ, Tarantino LM. Characterization of genetically complex Collaborative Cross mouse strains that model divergent locomotor activating and reinforcing properties of cocaine. Psychopharmacology (Berl). 2020 Apr;237(4):979-996. doi: 10.1007/s00213-019-05429-3. Epub 2020 Jan 3. PMID: 31897574; PMCID: PMC7542678. PDF

Logan RW. Adapting Social Defeat Stress for Female Mice Using Species-Typical Interfemale Aggression. Biol Psychiatry. 2019 Nov 1;86(9):e31-e32. doi: 10.1016/j.biopsych.2019.08.007. PMID: 31601365. PDF

Seney ML, Cahill K, Enwright JF 3rd, Logan RW, Huo Z, Zong W, Tseng G, McClung CA. Diurnal rhythms in gene expression in the prefrontal cortex in schizophrenia. Nat Commun. 2019 Aug 9;10(1):3355. doi: 10.1038/s41467-019-11335-1. PMID: 31399567; PMCID: PMC6689017. PDF

Barko K, Paden W, Cahill KM, Seney ML, Logan RW. Sex-Specific Effects of Stress on Mood-Related Gene Expression. Mol Neuropsychiatry. 2019 Jun;5(3):162-175. doi: 10.1159/000499105. Epub 2019 Apr 30. PMID: 31312637; PMCID: PMC6597924. PDF

Parekh PK, Logan RW, Ketchesin KD, Becker-Krail D, Shelton MA, Hildebrand MA, Barko K, Huang YH, McClung CA. Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2. J Neurosci. 2019 Jun 12;39(24):4657-4667. doi: 10.1523/JNEUROSCI.2233-18.2019. Epub 2019 Apr 8. PMID: 30962277; PMCID: PMC6561687. PDF

Freyberg Z, Logan RW. The Intertwined Roles of Circadian Rhythms and Neuronal Metabolism Fueling Drug Reward and Addiction. Curr Opin Physiol. 2018 Oct;5:80-89. doi: 10.1016/j.cophys.2018.08.004. Epub 2018 Sep 5. PMID: 30631826; PMCID: PMC6322667. PDF

Logan RW, McClung CA. Rhythms of life: circadian disruption and brain disorders across the lifespan. Nat Rev Neurosci. 2019 Jan;20(1):49-65. doi: 10.1038/s41583-018-0088-y. PMID: 30459365; PMCID: PMC6338075. PDF

Cahill KM, Huo Z, Tseng GC, Logan RW, Seney ML. Improved identification of concordant and discordant gene expression signatures using an updated rank-rank hypergeometric overlap approach. Sci Rep. 2018 Jun 25;8(1):9588. doi: 10.1038/s41598-018-27903-2. PMID: 29942049; PMCID: PMC6018631. PDF

Walker DM, Cates HM, Loh YE, Purushothaman I, Ramakrishnan A, Cahill KM, Lardner CK, Godino A, Kronman HG, Rabkin J, Lorsch ZS, Mews P, Doyle MA, Feng J, Labonté B, Koo JW, Bagot RC, Logan RW, Seney ML, Calipari ES, Shen L, Nestler EJ. Cocaine Self-administration Alters Transcriptome-wide Responses in the Brain’s Reward Circuitry. Biol Psychiatry. 2018 Dec 15;84(12):867-880. doi: 10.1016/j.biopsych.2018.04.009. Epub 2018 Apr 25. PMID: 29861096; PMCID: PMC6202276. PDF

Logan RW, Parekh PK, Kaplan GN, Becker-Krail DD, Williams WP 3rd, Yamaguchi S, Yoshino J, Shelton MA, Zhu X, Zhang H, Waplinger S, Fitzgerald E, Oliver-Smith J, Sundarvelu P, Enwright JF 3rd, Huang YH, McClung CA. NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward. Mol Psychiatry. 2019 Nov;24(11):1668-1684. doi: 10.1038/s41380-018-0061-1. Epub 2018 May 4. PMID: 29728703; PMCID: PMC6215755. PDF

Purohit K, Parekh PK, Kern J, Logan RW, Liu Z, Huang Y, McClung CA, Crabbe JC, Ozburn AR. Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge-Like Alcohol Drinking in Mice. Alcohol Clin Exp Res. 2018 May;42(5):879-888. doi: 10.1111/acer.13626. Epub 2018 Apr 18. PMID: 29668112; PMCID: PMC6034712. PDF

Seney ML, Huo Z, Cahill K, French L, Puralewski R, Zhang J, Logan RW, Tseng G, Lewis DA, Sibille E. Opposite Molecular Signatures of Depression in Men and Women. Biol Psychiatry. 2018 Jul 1;84(1):18-27. doi: 10.1016/j.biopsych.2018.01.017. Epub 2018 Feb 19. PMID: 29548746; PMCID: PMC6014892. PDF

Logan RW, Hasler BP, Forbes EE, Franzen PL, Torregrossa MM, Huang YH, Buysse DJ, Clark DB, McClung CA. Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents. Biol Psychiatry. 2018 Jun 15;83(12):987-996. doi: 10.1016/j.biopsych.2017.11.035. Epub 2017 Dec 15. PMID: 29373120; PMCID: PMC5972052. PDF

DePoy LM, McClung CA, Logan RW. Neural Mechanisms of Circadian Regulation of Natural and Drug Reward. Neural Plast. 2017;2017:5720842. doi: 10.1155/2017/5720842. Epub 2017 Nov 21. PMID: 29359051; PMCID: PMC5735684. PDF

Ozburn AR, Kern J, Parekh PK, Logan RW, Liu Z, Falcon E, Becker-Krail D, Purohit K, Edgar NM, Huang Y, McClung CA. NPAS2 Regulation of Anxiety-Like Behavior and GABAA Receptors. Front Mol Neurosci. 2017 Nov 3;10:360. doi: 10.3389/fnmol.2017.00360. PMID: 29163035; PMCID: PMC5675889. PDF

Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, Sheridan SD, Logan RW, Brandel M, Wu D, Hunsberger J, Dorsett L, Duerr C, Basa RCB, McCarthy MJ, Udeshi ND, Mertins P, Carr SA, Rouleau GA, Mastrangelo L, Li J, Gutierrez GJ, Brill LM, Venizelos N, Chen G, Nye JS, Manji H, Price JH, McClung CA, Akiskal HS, Alda M, Chuang DM, Coyle JT, Liu Y, Teng YD, Ohshima T, Mikoshiba K, Sidman RL, Halpain S, Haggarty SJ, Goshima Y, Snyder EY. Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proc Natl Acad Sci U S A. 2017 May 30;114(22):E4462-E4471. doi: 10.1073/pnas.1700111114. Epub 2017 May 12. PMID: 28500272; PMCID: PMC5465887. PDF

Cribbet MR, Logan RW, Edwards MD, Hanlon E, Bien Peek C, Stubblefield JJ, Vasudevan S, Ritchey F, Frank E. Circadian rhythms and metabolism: from the brain to the gut and back again. Ann N Y Acad Sci. 2016 Dec;1385(1):21-40. doi: 10.1111/nyas.13188. Epub 2016 Sep 2. PMID: 27589593; PMCID: PMC5428740. PDF

Chen CY, Logan RW, Ma T, Lewis DA, Tseng GC, Sibille E, McClung CA. Effects of aging on circadian patterns of gene expression in the human prefrontal cortex. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):206-11. doi: 10.1073/pnas.1508249112. Epub 2015 Dec 22. PMID: 26699485; PMCID: PMC4711850. PDF

Nascimento NF, Hicks JA, Carlson KN, Hatzidis A, Amaral DN, Logan RW, Seggio JA. Long-term wheel-running and acute 6-h advances alter glucose tolerance and insulin levels in TALLYHO/JngJ mice. Chronobiol Int. 2016;33(1):108-16. doi: 10.3109/07420528.2015.1108330. Epub 2015 Dec 10. PMID: 26654732. PDF

Logan RW, McClung CA. Animal models of bipolar mania: The past, present and future. Neuroscience. 2016 May 3;321:163-188. doi: 10.1016/j.neuroscience.2015.08.041. Epub 2015 Aug 24. PMID: 26314632; PMCID: PMC4766066. PDF

Nascimento NF, Carlson KN, Amaral DN, Logan RW, Seggio JA. Alcohol and lithium have opposing effects on the period and phase of the behavioral free-running activity rhythm. Alcohol. 2015 Jun;49(4):367-76. doi: 10.1016/j.alcohol.2015.02.006. Epub 2015 Mar 16. PMID: 25850902. PDF

Logan RW, Edgar N, Gillman AG, Hoffman D, Zhu X, McClung CA. Chronic Stress Induces Brain Region-Specific Alterations of Molecular Rhythms that Correlate with Depression-like Behavior in Mice. Biol Psychiatry. 2015 Aug 15;78(4):249-58. doi: 10.1016/j.biopsych.2015.01.011. Epub 2015 Feb 4. PMID: 25771506; PMCID: PMC4509914. PDF

Logan RW, Wynne O, Maglakelidze G, Zhang C, O’Connell S, Boyadjieva NI, Sarkar DK. β-Endorphin neuronal transplantation into the hypothalamus alters anxiety-like behaviors in prenatal alcohol-exposed rats and alcohol-non-preferring and alcohol-preferring rats. Alcohol Clin Exp Res. 2015 Jan;39(1):146-57. doi: 10.1111/acer.12611. PMID: 25623413; PMCID: PMC4521638. PDF

Logan RW, Williams WP 3rd, McClung CA. Circadian rhythms and addiction: mechanistic insights and future directions. Behav Neurosci. 2014 Jun;128(3):387-412. doi: 10.1037/a0036268. Epub 2014 Apr 14. PMID: 24731209; PMCID: PMC4041815. PDF

Logan RW, Robledo RF, Recla JM, Philip VM, Bubier JA, Jay JJ, Harwood C, Wilcox T, Gatti DM, Bult CJ, Churchill GA, Chesler EJ. High-precision genetic mapping of behavioral traits in the diversity outbred mouse population. Genes Brain Behav. 2013 Jun;12(4):424-37. doi: 10.1111/gbb.12029. Epub 2013 Mar 20. PMID: 23433259; PMCID: PMC3709837. PDF

Logan RW, Wynne O, Levitt D, Price D, Sarkar DK. Altered circadian expression of cytokines and cytolytic factors in splenic natural killer cells of Per1(-/-) mutant mice. J Interferon Cytokine Res. 2013 Mar;33(3):108-14. doi: 10.1089/jir.2012.0092. Epub 2013 Feb 12. PMID: 23402528; PMCID: PMC3595954. PDF

Logan RW, Sarkar DK. Genetic variation of the natural killer gene complex has a role in lung cancer susceptibility. J Thorac Dis. 2013 Feb;5(1):3-5. doi: 10.3978/j.issn.2072-1439.2012.11.12. PMID: 23372942; PMCID: PMC3548001. PDF

Agapito MA, Barreira JC, Logan RW, Sarkar DK. Evidence for possible period 2 gene mediation of the effects of alcohol exposure during the postnatal period on genes associated with maintaining metabolic signaling in the mouse hypothalamus. Alcohol Clin Exp Res. 2013 Feb;37(2):263-9. doi: 10.1111/j.1530-0277.2012.01871.x. Epub 2012 Jul 23. PMID: 22823489; PMCID: PMC3480963. PDF

Logan RW, Zhang C, Murugan S, O’Connell S, Levitt D, Rosenwasser AM, Sarkar DK. Chronic shift-lag alters the circadian clock of NK cells and promotes lung cancer growth in rats. J Immunol. 2012 Mar 15;188(6):2583-91. doi: 10.4049/jimmunol.1102715. Epub 2012 Feb 3. PMID: 22308312; PMCID: PMC3294088. PDF

Logan RW, McCulley WD 3rd, Seggio JA, Rosenwasser AM. Effects of withdrawal from chronic intermittent ethanol vapor on the level and circadian periodicity of running-wheel activity in C57BL/6J and C3H/HeJ mice. Alcohol Clin Exp Res. 2012 Mar;36(3):467-76. doi: 10.1111/j.1530-0277.2011.01634.x. Epub 2011 Oct 20. PMID: 22013893; PMCID: PMC3266959. PDF

Logan RW, Sarkar DK. Circadian nature of immune function. Mol Cell Endocrinol. 2012 Feb 5;349(1):82-90. doi: 10.1016/j.mce.2011.06.039. Epub 2011 Jul 18. PMID: 21784128. PDF

Logan RW, Arjona A, Sarkar DK. Role of sympathetic nervous system in the entrainment of circadian natural-killer cell function. Brain Behav Immun. 2011 Jan;25(1):101-9. doi: 10.1016/j.bbi.2010.08.007. Epub 2010 Sep 8. PMID: 20816749; PMCID: PMC2991610. PDF

Logan RW, Seggio JA, Robinson SL, Richard GR, Rosenwasser AM. Circadian wheel-running activity during withdrawal from chronic intermittent ethanol exposure in mice. Alcohol. 2010 May;44(3):239-44. doi: 10.1016/j.alcohol.2010.02.011. PMID: 20682191; PMCID: PMC2916875. PDF

Seggio JA, Logan RW, Rosenwasser AM. Chronic ethanol intake modulates photic and non-photic circadian phase responses in the Syrian hamster. Pharmacol Biochem Behav. 2007 Aug-Sep;87(3):297-305. doi: 10.1016/j.pbb.2007.05.001. Epub 2007 May 10. PMID: 17544066; PMCID: PMC1989109. PDF

Rosenwasser AM, Fecteau ME, Logan RW, Reed JD, Cotter SJ, Seggio JA. Circadian activity rhythms in selectively bred ethanol-preferring and nonpreferring rats. Alcohol. 2005 Jun;36(2):69-81. doi: 10.1016/j.alcohol.2005.07.001. PMID: 16396740. PDF

Rosenwasser AM, Logan RW, Fecteau ME. Chronic ethanol intake alters circadian period-responses to brief light pulses in rats. Chronobiol Int. 2005;22(2):227-36. doi: 10.1081/cbi-200053496. PMID: 16021840. PDF

Rosenwasser AM, Fecteau ME, Logan RW. Effects of ethanol intake and ethanol withdrawal on free-running circadian activity rhythms in rats. Physiol Behav. 2005 Mar 31;84(4):537-42. doi: 10.1016/j.physbeh.2005.01.016. PMID: 15811388. PDF

 

Book Chapters

Chesler EJ, Logan RW. Opportunities for bioinformatics in the classification of behavior and psychiatric disorders. Int Rev Neurobiol. 2012;104:183-211. doi: 10.1016/B978-0-12-398323-7.00008-2. PMID: 23195316. PDF

Barko K, Shelton MA, Seggio JA, Logan RW. Circadian Rhythms and Addiction. Neural Mechanisms of Addiction. 2019:189-212. PDF