{"id":38,"date":"2014-02-24T14:46:26","date_gmt":"2014-02-24T19:46:26","guid":{"rendered":"https:\/\/sites.bu.edu\/liugroup\/?page_id=38"},"modified":"2021-08-27T13:59:06","modified_gmt":"2021-08-27T17:59:06","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/liugroup\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"<p>See more publications of Prof. Liu in <a href=\"https:\/\/scholar.google.co.uk\/citations?hl=en&amp;user=2mFsCD8AAAAJ&amp;view_op=list_works&amp;sortby=pubdate\">Google Scholar<\/a><\/p>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<h3>2021<\/h3>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li><span>Naowarojna, Nathchar, Ronghai Cheng, Juan Lopez, Christina Wong, Lu Qiao, and Pinghua Liu. &#8220;Chemical modifications of proteins and their applications in metalloenzyme studies.&#8221;\u00a0<\/span><i>Synthetic and systems biotechnology<\/i><span>\u00a06, no. 1 (2021): 32-49.<\/span><\/li>\n<li><span>Cheng, Ronghai, Rui Lai, Chao Peng, Juan Lopez, Zhihong Li, Nathchar Naowarojna, Kelin Li et al. &#8220;Implications for an Imidazole-2-yl Carbene Intermediate in the Rhodanase-Catalyzed C\u2013S Bond Formation Reaction of Anaerobic Ergothioneine Biosynthesis.&#8221;\u00a0<\/span><i>ACS catalysis<\/i><span>\u00a011, no. 6 (2021): 3319-3334.<\/span><\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<h3>2020<\/h3>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li><span>Cheng, Ronghai, Lian Wu, Rui Lai, Chao Peng, Nathchar Naowarojna, Weiyao Hu, Xinhao Li et al. &#8220;Single-step replacement of an unreactive C\u2013H bond by a C\u2013S bond using polysulfide as the direct sulfur source in the anaerobic ergothioneine biosynthesis.&#8221;\u00a0<\/span><i>ACS catalysis<\/i><span>\u00a010, no. 16 (2020): 8981-8994.<\/span><\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<h3><strong>2019<\/strong><\/h3>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li style=\"list-style-type: none;\">\n<ol>\n<li><span>Song, H., Naowarojna, N., Cheng, R., Lopez, J., &amp; Liu, P. (2019). Non-heme iron enzyme-catalyzed complex transformations: endoperoxidation, cyclopropanation, orthoester, oxidative CC and CS bond formation reactions in natural product biosynthesis.\u00a0<\/span><i>Advances in protein chemistry and structural biology<\/i><span>,\u00a0<\/span><i>117<\/i><span>, 1-61.<\/span><\/li>\n<li><span>Naowarojna, Nathchar, Seema Irani, Weiyao Hu, Ronghai Cheng, Li Zhang, Xinhao Li, Jiesheng Chen, Yan Jessie Zhang, and Pinghua Liu. &#8220;Crystal structure of the ergothioneine sulfoxide synthase from Candidatus Chloracidobacterium thermophilum and structure-guided engineering to modulate its substrate selectivity.&#8221;\u00a0<\/span><i>ACS catalysis<\/i><span>\u00a09, no. 8 (2019): 6955-6961.<\/span><\/li>\n<li><span>Deng, Qian, Yang Liu, Linyue Chen, Meiling Xu, Nathchar Naowarojna, Norman Lee, Li Chen et al. &#8220;Biochemical Characterization of a Multifunctional Mononuclear Nonheme Iron Enzyme (PtlD) in Neopentalenoketolactone Biosynthesis.&#8221;\u00a0<\/span><i>Organic letters<\/i><span>\u00a021, no. 18 (2019): 7592-7596.<\/span><\/li>\n<li><span>An, Xingda, Nathchar Naowarojna, Pinghua Liu, and Bjorn M. Reinhard. &#8220;Hybrid plasmonic photoreactors as visible light-mediated bactericides.&#8221;\u00a0<\/span><i>ACS applied materials &amp; interfaces<\/i><span>\u00a012, no. 1 (2019): 106-116.<\/span><\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n<ul>\n<li style=\"list-style-type: none;\">\n<ul>\n<li>\n<h3>2018<\/h3>\n<ol>\n<li><span>Naowarojna, Nathchar\u2020, Ronghai Cheng\u2020, Li Chen\u2020, Melissa Quill, Meiling Xu, Changming Zhao, and <strong>Pinghua Liu.<\/strong> &#8220;Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis.&#8221;\u00a0<\/span><i>Biochemistry<\/i><span>\u00a0(2018).<\/span><\/li>\n<li><span>Chen, Li, Nathchar Naowarojna, Heng Song, Shu Wang, Jiangyun Wang, Zixin Deng, Changming Zhao, and <strong>Pinghua Liu<\/strong>. &#8220;Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C\u2013S Bond Formation.&#8221;\u00a0<\/span><i>Journal of the American Chemical Society<\/i><span>\u00a0140, no. 13 (2018): 4604-4612.<\/span><\/li>\n<li><span>Irani, Seema\u2020, Nathchar Naowarojna\u2020, Yang Tang, Karan R. Kathuria, Shu Wang, Anxhela Dhembi, Norman Lee et al. &#8220;Snapshots of CS Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism.&#8221;\u00a0<\/span><i>Cell chemical biology<\/i><span>\u00a025, no. 5 (2018): 519-529.<\/span><\/li>\n<li>Shu-Shan Gao,\u2020 Nathchar Naowarojna,\u2020 Ronghai Cheng,\u2020 Xueting Liu,* and Pinghua Liu,*\u00a0 \u201cRecent Examples of a-Ketoglutarate-Dependent Mononuclear Non-Haem Iron Enzymes in Natural Product Biosyntheses and Metabolisms. Nat. Prod. Rep., 2018, 35, 792 &#8211; 837. \u2020Contributed equally to the work.<\/li>\n<li>R. Zhang, Y. Hong, B. M. Reinhard, Pinghua Liu, Ren Wang, and L. Dal Negro*, \u201cScalable cylindrical nanotrough networks for Raman-based biosensing\u201d, ACS Appl. Mater. Interface, 2018, 10 (33), 27928\u201327935<\/li>\n<li>Nathchar Naowarojna,\u2020 Pei Huang,\u2020 Yujuan Cai, Heng Song, Lian Wu, Ronghai Cheng, Yan Li, Shu Wang, Huijue Lyu, Lixin Zhang, Jiahai Zhou,* Pinghua Liu* \u201cCharacterization of the Remaining Steps in Ovothiol A Biosynthetic Pathway: C-S Lyase and Methyltrasferase\u201d Org. Lett 2018, DOI: 10.1021\/acs.orglett.8b02332, \u2020Contributed equally to the work.<\/li>\n<li>Wei-chen Chang,* Pinghua Liu,* and Yisong Guo,* \u201cMechanistic Elucidation of Catalytically Versatile Iron(II) and \u03b1-Ketoglutarate Dependent Enzymes: Cases Beyond Hydroxylation\u201d, Inorg. Chem., 2018, in press.<\/li>\n<li>Naowarojna, N.<span>\u2020<\/span>, Huang, P.<span>\u2020<\/span>, Cai, Y.<span>\u2020<\/span>, Song, H., Wu, L., Cheng, R., Li, Y., Wang, S., Lyu, H., Zhang, L. and Zhou, J., 2018. In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C\u2013S Lyase and Methyltransferase Reactions. Org. lett., 20(17), pp.5427-5430.<\/li>\n<li>Chen, L., Naowarojna, N., Chen, B., Xu, M., Quill, M., Wang, J., &#8230; &amp; Liu, P. (2018). Mechanistic studies of a nonheme iron enzyme OvoA in ovothiol biosynthesis using a tyrosine analogue, 2-amino-3-(4-hydroxy-3-(methoxyl) phenyl) propanoic acid (MeOTyr). ACS Catal., 9(1), 253-258.<\/li>\n<\/ol>\n<\/li>\n<li>\n<h3>2017<\/h3>\n<ol>\n<li>Pinghua Liu, and Lubin Jiang. &#8220;Conditional knockout tools: Application of site-specific incorporation of unnatural amino acid via genetic code expansion in viral and parasite vaccine development.&#8221;\u00a0<em>Synthetic and systems biotechnology<\/em>1 (2017): 2.<\/li>\n<li>Kathuria, K. R., Irani, S., Liu, P., &amp; Zhang, Y. (2017). Examining the Mechanism of Egt2 in Ergothioneine Biosynthesis.<em><\/em>The FASEB Journal,\u00a031(1 Supplement), 606-8.<\/li>\n<li><span>Qin, L., Chen, C., Chen, L., Xue, R., Ou-Yang, M., Zhou, C., Zhao, S., He, Z., Xia, Y., He, J. and Liu, P., 2017. Worldwide malaria incidence and cancer mortality are inversely associated.\u00a0<\/span><i>Infectious agents and cancer<\/i><span>,\u00a0<\/span><i>12<\/i><span>(1), p.14.<\/span><\/li>\n<\/ol>\n<\/li>\n<li>\n<h3>2016<\/h3>\n<ol>\n<li>Christian G. Roessler, Rakhi Agarwal, Stuart Myers, Anthony Kuczewski, Matthew Cowan, Babak Andi, Annie H\u00e9roux, Jan Kern, Rosalie Tran, Ruchira Chatterjee, Guangye Han, Junko Yano, Vittal Yachandra, Anthony Gizzi, Jeffrey B. Bonanno, James D. Love, Steven C. Almo, Eunsun Cho, Heng Song,\u00a0<strong>Pinghua Liu<\/strong>, Jos\u00e9 F. R. Bachega, Richard C. Garratt, Sammy Datwani, Brent Eaton, Richard Ellson, Lucien P. Ghislain, Lars Majlof, William M. McClintock, Joe Olechno, Richard G. Stearns, Carrie M. Wilmot, Erik T. Yukl, Victor L. Davidson, Aaron S. Brewster, Johan Hattne, Monarin Uervirojnangkoorn, YingssuTsai, Diling Zhu, Roberto Alonso-Mori, Silke Nelsen, Nicholas K. Sauter, Henrik Lemke, Aina Cohen, S. Michael Soltis, Marc Allaire, Alexei S. Soares, &amp; Allen M. Orville, \u201c Acoustic injectors for drop-on-demand serial femtosecond crystallography\u201d,\u00a0<em>Structure<\/em>,\u00a0<strong>2016,\u00a0<\/strong>24 (4),, 631\u2013640<\/li>\n<li>Li Qin, Changzhong Chen, Lili Chen, Ran Xue, Jingping Zheng, Ming Ou-Yang, Susu Gao, Zhengxiang He, Qinyan Li, Xibao Shi, Wanwan Xu, Siting Zhao, Brandon Xia, Jianxing He,\u00a0<strong>Pinghua Liu<\/strong>, Nanshan Zhong,* Xiaoping Chen.* \u201cWorld-wide epidemiological data analysis: an inverse association between malaria and cancer\u201d,\u00a0<em>PLos One.<\/em>2016<\/li>\n<li>James Kirby<sup>b,c,<\/sup>*, Kevin Dietzel<sup>a,<\/sup>*, Gale Wichmann<sup>a,<\/sup>*, Rossana Chan<sup>b,c<\/sup>, Eugene Antipov<sup>a<\/sup>, Nathan Moss, Edward E. K. Baidoo, Peter Jackson, Sara Gaucher, Shayin Gottlieb, Jeremy LaBarge, Tina Mahatdejkul, Kristy Hawkins, Sheela Muley, Jack Newman, Pinghua Liu, Jay D. Keasling and Lishan Zhao, \u201cEngineering a functional 1-deoxy-D-xylulose 5-phosphate (DXP) pathway in\u00a0<em>Saccharomyces cerevisiae\u201d, Metab. Eng. In revision.<\/em><\/li>\n<\/ol>\n<\/li>\n<li>\n<h3>2015<\/h3>\n<ol>\n<li>Wupeng Yan<sup>1\u2020<\/sup>, Heng Song<sup>2\u2020<\/sup>, Fuhang Song<sup>3<\/sup>, Cheng-Hsuan Wu<sup>2<\/sup>, Ampon Sae Her<sup>2<\/sup>, Yi Pu<sup>2,4<\/sup>, Shu Wang<sup>2<\/sup>, Catherine E. Costello<sup>2,4<\/sup>, Lixin Zhang<sup>3*<\/sup>, Pinghua Liu<sup>2*<\/sup>, and Yan Zhang<sup>1,5* \u201c<\/sup>Endoperoxide Formation Catalyzed by FtmOx1, an \u03b1-Ketoglutarate-dependent Mononuclear Non-heme Iron Enzyme\u201d,\u00a0<em>Nature<\/em>,\u00a0<strong>2015<\/strong>, 527, 539\u2013543.<\/li>\n<li>Luwen Ning<sup>1#<\/sup>, Guan Wang<sup>2#<\/sup>, Zhoufang Li<sup>1#<\/sup>, Wen Hu<sup>3, 4#<\/sup>, Qingming Hou<sup>2<\/sup>, Yin Tong<sup>1<\/sup>, Meng Zhang<sup>1<\/sup>, Li Qin<sup>4<\/sup>, Xiaoping Chen<sup>4<\/sup>,\u00a0Heng-Ye Man<sup>2<\/sup>*,\u00a0<strong>Pinghua Liu<\/strong><sup>3<\/sup>*, Jiankui He<sup>1<\/sup>*<sup>\u201c<\/sup>Quantitative assessment of single-cell sequencing methods using hippocampal neurons\u201d,\u00a0<em><\/em>,\u00a0<strong>2015<\/strong>; 5: 11415.<\/li>\n<li>Heng Song, Wen Hu, Ampon SaeHer, Rushil Desai, Li Qin,* Xiaoping Chen,* and Pinghua Liu*. \u201cMechanistic studies of a novel C-S lyase in ergothioneine biosynthesis: the involvement of a sulfenic acid intermediate\u201d,\u00a0<em>Rep.<\/em>,\u00a0<strong>2015<\/strong>; 5: 11870<\/li>\n<\/ol>\n<\/li>\n<li>\n<h3>2014<\/h3>\n<ol>\n<li>Heng Song, Ampon Sae Her, Fiona Raso, Zhibin Zhen, and Pinghua Liu*,\u201d Cysteine Oxidation Reactions Catalyzed by a Mononuclear Non-heme Iron Enzyme (OvoA) in Ovothiol Biosynthesis.\u00a0<em><\/em>,\u00a0<strong>2014<\/strong>, 16 (8), 2122\u20132125<\/li>\n<li>Wen Hu, Heng Song, Ampon SaeHer, Daniel W. Bak, Nathchar Naowarojna, Sean J. Elliott, Li Qin,* Xiaoping Chen,* and\u00a0<strong>Pinghua Liu<\/strong>*. \u201cBioinformatic and biochemical characterizations of C-S bond formation and cleavage enzymes in the fungal Neurospora crassa ergothioneine biosynthetic pathway\u201d,\u00a0<em>Lett.<\/em>,\u00a0<strong>2014<\/strong>, 16 (20), 5382\u20135385<\/li>\n<\/ol>\n<\/li>\n<li>\n<h3><strong>2013<\/strong><\/h3>\n<ol>\n<li>Wei-chen Chang, Mishtu Dey,\u00a0<strong>Pinghua Liu<\/strong>, Steven O. Mansoorabadi, Sung-Ju Moon, Zongbao Zhao, Catherine L. Drennan, and Hung-wen Liu, \u201cAn unprecedented 1,2-phosphono migration catalyzed by (<em>S<\/em>)-2-hydroxypropylphosphonate epoxidase provides evidence for the intermediacy of a cation species in a non-heme mononuclear iron-dependent enzyme-catalyzed reaction\u201d,\u00a0<em>Nature,\u00a0<\/em><strong>2013<\/strong><em>,\u00a0<\/em>496<em>,\u00a0<\/em>114 \u2013 118.<\/li>\n<li>Lishan Zhao, Wei-chen Chang, Youli Xiao, and Hung-wen Liu, and\u00a0<strong>Pinghua Liu<\/strong>,* \u201cIsoprenoid Biosynthesis: Mechanistic Studies of the Mevalonate and Deoxyxylulose Phosphate Pathways and Their Biomedical Applications\u201d, Invited review,\u00a0<em> Biochem.<\/em>,\u00a0<strong>2013<\/strong><em>,\u00a0<\/em>82<em>,\u00a0<\/em>497 \u2013 530.<\/li>\n<li>Heng Song, Maureen Leninger, Norman Lee, and Pinghua Liu*,\u201d Regioselectivity of the oxidative C-S bond formation in ergothioneine and ovothiol biosyntheses\u201d,\u00a0<em>Lett<\/em>.\u00a0<strong>2013<\/strong>, 15, 4854 \u2013 4857.<\/li>\n<li>Wei-chen Chang, Heng Song, and Hung-wen Liu,* and\u00a0<strong>Pinghua Liu<\/strong>,* \u201cCurrent Development in Isoprenoid Precursor Biosynthesis and Regulation\u201d, Invited review,\u00a0<em>Opin. Chem. Biol.<\/em>,\u00a0<strong>2013<\/strong>, 17, 571 -579.<\/li>\n<\/ol>\n<\/li>\n<li>\n<h3><strong>2012<\/strong><\/h3>\n<p>Kelly Daughtry, Youli Xiao, Deborah Stoner-Ma, Eunsun Cho, Allen M. Orville,\u00a0<strong>Pinghua Liu<\/strong>*, and Karen N. Allen*, \u201cQuaternary Ammonium Oxidative Demethylation: X-ray Crystallographic and on-beam Raman and UV-visible Spectroscopic\u00a0 Characterization of a Rieske-type Demethylase\u201d,\u00a0<em>Am. Chem. Soc.,\u00a0<\/em><strong>2012<\/strong><em>,\u00a0<\/em>134, 2823-2834<em>.<\/em><\/li>\n<li>\n<h3><strong>2011<\/strong><\/h3>\n<ol>\n<li>Youli Xiao, Wei-chen Chang, Hung-wen Liu*, and\u00a0<strong>Pinghua Liu<\/strong>*, \u201cStudy of IspH, a Key Enzyme in the Methylerythritol Phosphate Pathway Using Fluoro-Substituted Substrate Analogues\u201d,\u00a0<em><\/em><strong>2011<\/strong>, 13, 5912\u20135915<em>.<\/em><\/li>\n<li>Youli Xiao, Debra Rooker, Quincy Young, Caren L. Freel Meyers,\u00a0<strong>Pinghua Liu<\/strong>*. \u201cIspG-Catalyzed Positional Isotopic Exchange in Methylerythritol Cyclodiphosphate of the Deoxyxylulose Phosphate Pathway: Mechanistic Implications\u201d\u00a0<em>ChemBiochem<\/em>,\u00a0<strong>2011<\/strong>, 12, 527-530<em>.<\/em><\/li>\n<li>Wei-chen Chang, Youli Xiao, Hung-wen Liu,* and\u00a0<strong>Pinghua Liu<\/strong>,* \u201cMechanistic Studies of an IspH-Catalyzed Reaction: Implications for Substrate Binding and Protonation in the Biosynthesis of Isoprenoids\u201d.\u00a0\u00a0<em>Chem.Int. Ed.,\u00a0<\/em><strong>2011<\/strong>, 50, 12304 \u201312307.<\/li>\n<\/ol>\n<\/li>\n<li>\n<h3><strong>2010<\/strong><\/h3>\n<ol>\n<li>Youli Xiao, Rodney L. Nyland II, Caren L. Freel Meyers,\u00a0<strong>Pinghua Liu<\/strong>*, \u201cMethylerythritol Cyclodiphosphate (MEcPP) in Deoxyxylulose Phosphate Pathway: Synthesis from an Epoxide and Mechanisms\u201d\u00a0<em>Commun<\/em>.,\u00a0<strong>2010<\/strong>,\u00a0 7220 \u2013 7222.<\/li>\n<\/ol>\n<\/li>\n<li>\n<h3><strong>2009<\/strong><\/h3>\n<ol>\n<li>Youli Xiao, Kent Lee, Miranda Machacek,<strong>Pinghua Liu*. \u201c<\/strong>Examing the prenyltransferase substrate binding pocket flexibility for isoprenoid profiling\u201d, invited\u00a0<em>Molecular Biosystems<\/em>\u00a0article for a special issue devoted to outstanding young scientists at the chemical- and systems-biology interfaces.\u00a0<strong>2009<\/strong>,\u00a0<em>5(9),\u00a0<\/em>913 \u2013 917<em>.<\/em><\/li>\n<li>Youli Xiao,\u00a0<strong>Pinghua Liu*<\/strong><em>.\u00a0\u00a0<\/em>\u201cSynthesis of stereo-specific isotopically-labeled substrate analogues of IspH enzyme in the deoxyxylulose phosphate pathway\u201d,\u00a0<em>Tetrahedron Lett.<\/em><strong>2009<\/strong>\u00a0<em>50, 309-311.<\/em><\/li>\n<li>Youli Xiao, Lisa Chu, Yiannis Sanakis,<strong>Pinghua Liu*<\/strong>. \u201cRevisiting the IspH Catalytic System in the Deoxyxylulose Phosphate Pathway: Achieving High Activity\u201d,<em> Chem. Soc.\u00a0\u00a0<\/em><strong>2009<\/strong><em>, 131(29),\u00a0<\/em>9931 \u2013 9933.<\/li>\n<li>Rodney L. Nyland II, Youli Xiao,\u00a0<strong>Pinghua Liu<\/strong>,* Caren L. Freel Meyers*<strong>. \u201c<\/strong>IspG converts an epoxide substrate analog to (<em>E<\/em>)-4-hydroxy-3-methylbut-2-enyl diphosphate: implications for IspG catalysis in isoprenoid biosynthesis\u201d\u00a0<em> Chem. Soc.,<\/em><strong>2009<\/strong><em>,131 (49),\u00a0<\/em>17734-17735<em>.<\/em><\/li>\n<li>Youli Xiao, Georgia Zahariou, Yiannis Sanakis, and\u00a0<strong>Pinghua Liu*<\/strong>. \u201cIspG Enzyme Activity in the Deoxyxylulose Phosphate Pathway: Roles of the Iron-Sulfur Cluster.\u201d\u00a0\u00a0<em>Biochemistry,<\/em><strong>2009<\/strong><em>, 48,\u00a0<\/em>10483 \u2013 10485<em>.<\/em><\/li>\n<\/ol>\n<\/li>\n<li>\n<h3><strong>2008 <\/strong><\/h3>\n<ol>\n<li>Youli Xiao, Zongbao Zhao<strong>, Pinghua Liu*.\u00a0 \u201c<\/strong>Mechanistic Studies of IspH in the Deoxyxylulose Phosphate Pathway: Heterolytic C-O Bond Cleavage at C<sub>4<\/sub>Position\u201d,\u00a0<em> Chem. Soc.\u00a0<\/em><strong>2008<\/strong>,<em>\u00a0130,\u00a0<\/em>2164-2165.<\/li>\n<li>Youli Xiao,<strong>Pinghua Liu*<em>.\u00a0\u00a0<\/em><\/strong>\u201cIspH Protein of the Deoxyxylulose Phosphate Pathway: Mechanistic Studies with C<sub>1<\/sub>\u00a0Deuterium Labelled Substrate and Fluorinated Analogues\u201d,\u00a0<em> Int. Ed.<\/em><strong>\u00a02008,\u00a0<\/strong><em>47<\/em>, 9722-9725.<\/li>\n<li>Youli Xiao, Kent Lee,\u00a0<strong>Pinghua Liu*<\/strong><em>.\u00a0\u00a0<\/em>\u201cSynthesis of the Substrate Candidates for P-methylation Enzyme in Bialaphos Biosynthesis:\u00a0<em>N<\/em>-acetyl-demethyl phosphinothricin and\u00a0<em>N<\/em>-acetyl-demethyl phosphinothricin tripeptide\u201d,\u00a0<em><\/em><strong>2008<\/strong>,\u00a0<em>10<\/em>, 5521\u20135524.<\/li>\n<\/ol>\n<\/li>\n<li>\n<h3>2001~2007<\/h3>\n<ol>\n<li><strong>Pinghua Liu<\/strong>, Kazuo Murakami, Takayuki Seki, Xuemei He, Siu-Man Yeung, Tomohisa Kuzuyama, Haruo Seto, and\u00a0<strong>Hung-wen Liu<\/strong>.\u00a0 \u201cProtein Purification and Function Assignment of the Epoxidase Catalyzing the\u00a0 Formation of Fosfomycin\u201d,\u00a0<em> Chem. Soc.\u00a0<\/em><strong>2001<\/strong>,<em>123,\u00a0<\/em>4619-4620.<\/li>\n<li>Zongbao Zhao*,<strong>Pinghua Liu*,\u00a0<\/strong>Kazuo Murakami, Tomohisa Kuzuyama, Haruo Seto, and Hung-wen Liu. \u201cMechanistic Studies of HPP Epoxidase: Configuration of the Substrate Governs Its Enzymatic Fate\u201d, * equal contribution;\u00a0<em> Int. Ed.<\/em>\u00a0<strong>2002<\/strong>,\u00a0<em>41,\u00a0<\/em>4529-32.<\/li>\n<li><strong>Pinghua Liu<\/strong>, Aimin Liu, Feng Yan, Matt D. Wolf, John D. Lipscomb, and Hung-wen Liu.<sup><\/sup>\u201cBiochemical and Spectroscopic Studies on (<em>S<\/em>)-2-Hydroxypropylphosphonic Acid Epoxidase: A Novel Mononuclear Non-heme Iron Enzyme\u201d,\u00a0<em>Biochemistry\u00a0<\/em><strong>2003<\/strong><em>, 42<\/em>, 11577-86.<\/li>\n<li><strong>Pinghua Liu<\/strong>, Mark Mehn, Feng Yan, Zongbao Zhao, Lawrence Que, Jr., and Hung-wen Liu. \u201cOxygenase Activity in the Self-Hydroxylation of (<em>S<\/em>)-2-Hydroxypropylphosphonic Acid Epoxidase Involved in Fosfomycin Biosynthesis\u201d,\u00a0<em> Chem. Soc.<\/em><strong>2004<\/strong>,\u00a0<em>126<\/em>, 10306-10312.<\/li>\n<li>Luke J. Higgins, Feng Yan,\u00a0<strong>Pinghua Liu<\/strong>,\u00a0<strong>Hung-wen Liu<\/strong>,\u00a0<strong>Catherine L. Drennan<\/strong><sup>.\u00a0<\/sup>\u201cStructural Insight into the Biosynthesis of the Antibiotic Fosfomycin by a Mononuclear Iron Enzyme\u201d,\u00a0<em>Nature<\/em>,\u00a0<strong>2005<\/strong>, 437, 838-844.<\/li>\n<li>JoAnne Stubbe, Jiamin Tian, Aimin He, Anthony J. Sinskey, Adam G. Lawrence, and\u00a0<strong>Pinghua Liu<\/strong>. \u201cNon-template dependent polymerization process: polyhydroxyalkanoate synthases as a paradigm\u201d\u00a0<em> Biochem.\u00a0<\/em><strong>2005<\/strong>,<em>74<\/em>, 433-480.<\/li>\n<li>Jiamin Tian, Aimin He, Adam G. Lawrence,\u00a0<strong>Pinghua Liu<\/strong><u>,<\/u>Anthony J. Sinskey, and JoAnne Stubbe. \u201cAnalysis of Transient Polyhydroxybutyrate Production in Ralstonia eutropha H16 using quantitative Westerns and Electron Microscopy\u201d,\u00a0<em><\/em>\u00a0<strong><em>2005<\/em><\/strong><em>, 187,\u00a0<\/em>3825-3832.<\/li>\n<li>Adam G. Lawrence, Joerg Schoenheit, Jiamin Tian, Aimin He,\u00a0<strong>Pinghua Liu<\/strong>, JoAnne Stubbe, and Anthony J. Sinskey. \u201cTranscriptional analysis of\u00a0<em>Ralstonia eutropha<\/em>genes related to poly-(<em>R<\/em>)-3-hydroxybutyrate homeostasis during batch fermentation\u201d,\u00a0<em> Biotech.<\/em><strong>,\u00a0<\/strong>2005,\u00a0<em>68<\/em>,\u00a0 663-672.<\/li>\n<li>Feng Yan, Jeffrey W. Munos,\u00a0<strong>Pinghua Liu,<\/strong>Hung-wen Liu \u201cBiosynthesis of Fosfomycin., Re-examination and Re-confirmation of A Uniqee Fe(II) and NAD(P)H-dependent Epoxidation Reaction\u201d.\u00a0\u00a0<em>Biochemistry<\/em>\u00a045, 11473-11481,\u00a0<strong>2006<\/strong>.<\/li>\n<li>Feng Yan, Sung-Ju Moon,\u00a0<strong>Pinghua Liu<\/strong>, Zongbao Zhao, John D. Lipscomb, Aimin Liu, and Hung-wen Liu<sup><\/sup>\u201cEffects of Isotope-enriched Substrates And Substrate Analogues on the Active Site Iron in (<em>S<\/em>)-2-Hydroxypropylphosphonic Acid Epoxidase (HppE)\u201d.\u00a0<em>Biochemistry<\/em>\u00a046 (44): 12628-12638,\u00a0<strong>2007<\/strong>.<\/li>\n<\/ol>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<h1>Patent<\/h1>\n<ul>\n<li style=\"list-style-type: none;\">\n<ol>\n<li><strong>Pinghua Liu<\/strong>, Heng Song, Wen Hu,\u201dProduction of ergothioneine by metabolic engineering (WO 2014100752 A1)\u201d, 2013<\/li>\n<\/ol>\n<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>See more publications of Prof. Liu in Google Scholar 2021 Naowarojna, Nathchar, Ronghai Cheng, Juan Lopez, Christina Wong, Lu Qiao, and Pinghua Liu. &#8220;Chemical modifications of proteins and their applications in metalloenzyme studies.&#8221;\u00a0Synthetic and systems biotechnology\u00a06, no. 1 (2021): 32-49. Cheng, Ronghai, Rui Lai, Chao Peng, Juan Lopez, Zhihong Li, Nathchar Naowarojna, Kelin Li et [&hellip;]<\/p>\n","protected":false},"author":6817,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/38"}],"collection":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/users\/6817"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/comments?post=38"}],"version-history":[{"count":15,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/38\/revisions"}],"predecessor-version":[{"id":374,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/38\/revisions\/374"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/media?parent=38"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}