{"id":28,"date":"2014-02-24T14:43:13","date_gmt":"2014-02-24T19:43:13","guid":{"rendered":"https:\/\/sites.bu.edu\/liugroup\/?page_id=28"},"modified":"2014-02-24T14:43:13","modified_gmt":"2014-02-24T19:43:13","slug":"a-enzymatic-mechanism-and-inhibitor-design","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/liugroup\/research\/natural-product-biosynthesis-biosynthetic-pathway-engineering-and-their-application\/a-enzymatic-mechanism-and-inhibitor-design\/","title":{"rendered":"A) Enzymatic mechanism and inhibitor design"},"content":{"rendered":"<p>All isoprenoids are assembled from IPP and DMAPP.<strong> <\/strong>In animals, isoprenoids are synthesized from mevalonic acid (MVA) via the MVA pathway whereas most pathogenic bacteria and malarial parasites utilize the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway.\u00a0 Our laboratory is interested in mechanistic studies of the DXP pathway enzymes by a combination of bioorganic and biophysical tools (EPR, ENDOR, M\u00f6ssbauer, Resonance raman spectroscopies and X-ray crystallography).\u00a0 The mechanistic studies will guide the development of mechanism-based inhibitors as new anti-microbial drugs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>All isoprenoids are assembled from IPP and DMAPP. In animals, isoprenoids are synthesized from mevalonic acid (MVA) via the MVA pathway whereas most pathogenic bacteria and malarial parasites utilize the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway.\u00a0 Our laboratory is interested in mechanistic studies of the DXP pathway enzymes by a combination of bioorganic and biophysical tools (EPR, [&hellip;]<\/p>\n","protected":false},"author":6817,"featured_media":0,"parent":26,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/28"}],"collection":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/users\/6817"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/comments?post=28"}],"version-history":[{"count":1,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/28\/revisions"}],"predecessor-version":[{"id":29,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/28\/revisions\/29"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/26"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/media?parent=28"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}