{"id":128,"date":"2015-07-16T09:23:56","date_gmt":"2015-07-16T13:23:56","guid":{"rendered":"https:\/\/sites.bu.edu\/liugroup\/?page_id=128"},"modified":"2015-07-16T09:24:05","modified_gmt":"2015-07-16T13:24:05","slug":"citation4","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/liugroup\/research\/citation4\/","title":{"rendered":"Compound 8 Mechanistic Studies"},"content":{"rendered":"<p><strong>Compound 8 Mechanistic Studies<\/strong><\/p>\n<p>It was also found that an intermediate in DXP pathway, 1-hydroxy-2-methyl-butenyl 4-diphosphate (8, Fig. 1), stimulates ?? T-cell proliferation at picomolar concentrations. It was proposed that compound 8 functions as a signaling molecule for the recognition of microbial infection by the human innate-immune system. The structure of compound 8 is significantly different from all known signaling molecules in innate-immune responses. Thus, it is reasonable to assume that compound 8 is recognized by an unknown T-cell receptor. Or the recognition of compound 8 represents a new function of a previously reported T-cell receptor. In this sub-area, the identity of the T-cell receptor and the detailed signal transduction pathways triggered by compound 8 will be elucidated by the combination of chemical and biological approaches.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Compound 8 Mechanistic Studies It was also found that an intermediate in DXP pathway, 1-hydroxy-2-methyl-butenyl 4-diphosphate (8, Fig. 1), stimulates ?? T-cell proliferation at picomolar concentrations. It was proposed that compound 8 functions as a signaling molecule for the recognition of microbial infection by the human innate-immune system. The structure of compound 8 is significantly [&hellip;]<\/p>\n","protected":false},"author":3733,"featured_media":0,"parent":18,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/128"}],"collection":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/users\/3733"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/comments?post=128"}],"version-history":[{"count":1,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/128\/revisions"}],"predecessor-version":[{"id":129,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/128\/revisions\/129"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/pages\/18"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/liugroup\/wp-json\/wp\/v2\/media?parent=128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}