{"id":2421,"date":"2025-08-12T15:14:02","date_gmt":"2025-08-12T19:14:02","guid":{"rendered":"https:\/\/sites.bu.edu\/kumarlab\/?page_id=2421"},"modified":"2026-03-17T14:23:29","modified_gmt":"2026-03-17T18:23:29","slug":"projects","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/kumarlab\/projects\/","title":{"rendered":"Projects"},"content":{"rendered":"<h3 style=\"text-align: left;\">Movement: Technologies<\/h3>\n<h4 class=\"page-title\"><span style=\"color: #ff0000;\"><span style=\"text-decoration: underline;\">M<\/span>eaningful <span style=\"text-decoration: underline;\">O<\/span>steoarthritis <span style=\"text-decoration: underline;\">D<\/span>igital <span style=\"text-decoration: underline;\">E<\/span>ndpoint<span style=\"text-decoration: underline;\">S<\/span> (MODES)<\/span><\/h4>\n<p><span>Given that the patient experience with knee osteoarthritis (OA) is primarily characterized by concurrent pain and walking limitations, this project aims to develop a novel composite digital endpoint tailored to integrate synchronous digital measures of pain and gait patterns in daily life. This endpoint has the potential to be more clinically meaningful, responsive, and ecologically valid than currently available measures. The project will employ a patient-centered approach within the Verification, Analytical Validation, Usability Validation, and Clinical Validation (V3+) framework.\u00a0<\/span><\/p>\n<p>Read more at the links below:<\/p>\n<ul>\n<li>Study website: <a href=\"https:\/\/sites.bu.edu\/modes\/\" target=\"_blank\" rel=\"noopener\">MODES<\/a><\/li>\n<li>Funding: <a href=\"https:\/\/reporter.nih.gov\/search\/bDtARxv6ukysMQIotkLxiw\/project-details\/11206133\" target=\"_blank\" rel=\"noopener noreferrer\">NIH-NINDS UG3<\/a><\/li>\n<\/ul>\n<h4><span style=\"color: #ff0000;\">Deep learning to estimate knee kinematics and kinetics from inertial sensors<\/span><\/h4>\n<p>We are using deep learning algorithms to derive accurate estimates of knee kinematics and kinetics from inertial sensors for applications to walking in real-world.<\/p>\n<p>Read more at the links below:<\/p>\n<ul>\n<li>Conference Abstract: <a href=\"https:\/\/www.oarsijournal.com\/article\/S1063-4584(23)00036-5\/fulltext\" target=\"_blank\" rel=\"noopener noreferrer\">Deep Learning Driven Estimation Of Knee Kinematics And Kinetics From Inertial Sensors During Walking In People With Knee Osteoarthritis<\/a><\/li>\n<\/ul>\n<h4><span style=\"color: #ff0000;\">Validation of markerless motion capture techniques<\/span><\/h4>\n<p>Leveraging the advances in AI-based markerless techniques for motion capture, we are conducting validation studies to estimate the agreement of these techniques for marker-based approaches.<\/p>\n<p>Read more at the links below:<\/p>\n<ul>\n<li>Conference Abstract: <a href=\"https:\/\/www.oarsijournal.com\/article\/S1063-4584(25)00282-1\/abstract\" target=\"_blank\" rel=\"noopener noreferrer\">Agreement between marker-based and markerless motion capture for assessment of kinematics and kinetics during functional activities in people with knee osteoarthritis<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3 style=\"text-align: left;\">Movement: Interventions<\/h3>\n<h4><span style=\"color: #ff0000;\">Music-based autonomous walking intervention for knee OA<\/span><\/h4>\n<p><span>People with knee OA<\/span><span>\u00a0experience impairments in both quality and quantity of walking.\u00a0<\/span>In this study, we are developing a novel wearable autonomous music-based rhythmic auditory stimulation (RAS) intervention to improve both quality and quantity of walking for people with knee OA.<\/p>\n<p>Read more at the links below:<\/p>\n<ul>\n<li>Publication (preprint): <a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2024.09.20.24313422v1.full\" target=\"_blank\" rel=\"noopener noreferrer\">Single-Session Feasibility of a Wearable Music-based Rhythmic Auditory Stimulation Device to Improve Walking in Knee Osteoarthritis<\/a><\/li>\n<\/ul>\n<h4><span style=\"color: #ff0000;\">Telehealth Exercise and Mindfulness for Pain in knee osteoarthritis (TEMPO)<\/span><\/h4>\n<p><span>This project is to determine the feasibility of a novel telehealth mindful exercise intervention for people with knee OA. Mindful exercise refers to application of mindfulness to structured exercise and daily physical activity. In this fully decentralized randomized controlled trial (RCT), participants with knee OA (n=62) are assigned to a 10-week, group- based, telehealth &#8211; mindful exercise or only exercise arms.\u00a0<\/span><\/p>\n<p>Read more at the links below:<\/p>\n<ul>\n<li>Funding: <a href=\"https:\/\/reporter.nih.gov\/search\/bDtARxv6ukysMQIotkLxiw\/project-details\/10880883\" target=\"_blank\" rel=\"noopener noreferrer\">NIH-NIAMS R21\u00a0<\/a><\/li>\n<li>Publication:\u00a0<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S266591312400061X\" target=\"_blank\" rel=\"noopener noreferrer\"><span class=\"title-text\">Telehealth mindful exercise for people with knee osteoarthritis: A decentralized feasibility randomized controlled trial<\/span><\/a><\/li>\n<li property=\"name\">Publication:\u00a0<a href=\"https:\/\/www.liebertpub.com\/doi\/abs\/10.1177\/27683605251364715\" target=\"_blank\" rel=\"noopener noreferrer\">Participant Experiences in Using a Telehealth Mindful Exercise Program for Knee Osteoarthritis: A Qualitative Study<\/a><\/li>\n<\/ul>\n<h4><span style=\"color: #ff0000;\">Positive Minds Strong Joints for knee OA (PMSJ-OA)<\/span><\/h4>\n<p>This project is to determine the feasibility of a mental and physical health intervention for Black adults with knee OA who also experience depressive and\/or anxiety symptoms. The Positive Minds Strong Joints (PMSJ) telehealth intervention includes individual mental health sessions and group exercise sessions over 10 weeks. This study will inform further modifications to PMSJ-OA guided by feedback from participants and interventionists, as well as strategies for sustainability and scalability.<\/p>\n<p>Read more at the links below:<\/p>\n<ul>\n<li>Funding: <a href=\"https:\/\/sites.bu.edu\/kumarlab\/2023\/07\/05\/new-rheumatology-research-foundation-grant\/\">Rheumatology Research Foundation Innovative Award<\/a><\/li>\n<\/ul>\n<hr \/>\n<h3 style=\"text-align: left;\">Movement: Mechanisms<\/h3>\n<h4><span style=\"color: #ff0000;\">Exercise-induced hypoalgesia in knee OA<\/span><\/h4>\n<p><span>The objective of this project is to examine the neurobiological mechanisms related to and impact of impaired exercise-induced hypoalgesia (EIH) in people with knee osteoarthritis (OA). This project is leveraging the current cycle of the Multicenter Osteoarthritis (MOST) Study to comprehensively examine the degree of impaired EIH in a cohort of adults with or at risk of knee OA, the inter-relations between nervous system dysfunction and impaired EIH, and their impacts on key physical and psychological outcomes.\u00a0<\/span><\/p>\n<p>Read more at the links below:<\/p>\n<ul>\n<li>Funding: <a href=\"https:\/\/reporter.nih.gov\/search\/FKDpWR0QkUWEv9kbNqjq6w\/project-details\/11056749\" target=\"_blank\" rel=\"noopener noreferrer\">NIH-NIA U19<\/a><\/li>\n<li>Publication: <a class=\"gsc_oci_title_link\" href=\"http:\/\/iranianra.ir\/files\/Journal2025\/Arthritis%20Care%20&amp;%20Research%202025%207.pdf#page=92\" data-clk=\"hl=en&amp;sa=T&amp;ei=LBnfaKCxOfnSieoP-pyZsQM\" target=\"_blank\" rel=\"noopener noreferrer\">Association of pain during exercise with exercise\u2010induced hypoalgesia in people with knee osteoarthritis<\/a><\/li>\n<\/ul>\n<h4><span style=\"color: #ff0000;\">Brain function underlying pain and altered movement in knee OA<\/span><\/h4>\n<p>Using concurrently assessed brain function (using functional near-infrared spectroscopy) and movement patterns (using wearable sensors), we are investigating the brain substrates underlying the influence of pain on neuromotor control during daily activities in people with knee OA.<\/p>\n<p>Read more at the links below:<\/p>\n<ul>\n<li>Publication: <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0331070\" target=\"_blank\" rel=\"noopener noreferrer\">Prefrontal cortex function and gait alterations during single- and dual-task walking in knee osteoarthritis<\/a><\/li>\n<li>Publication: <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2665913125000512\" target=\"_blank\" rel=\"noopener noreferrer\">Prefrontal cortex activation during daily movements and its association with clinical symptoms in knee osteoarthritis<\/a><\/li>\n<\/ul>\n<hr \/>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Movement: Technologies Meaningful Osteoarthritis Digital EndpointS (MODES) Given that the patient experience with knee osteoarthritis (OA) is primarily characterized by concurrent pain and walking limitations, this project aims to develop a novel composite digital endpoint tailored to integrate synchronous digital measures of pain and gait patterns in daily life. This endpoint has the potential to [&hellip;]<\/p>\n","protected":false},"author":13258,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/kumarlab\/wp-json\/wp\/v2\/pages\/2421"}],"collection":[{"href":"https:\/\/sites.bu.edu\/kumarlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/kumarlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/kumarlab\/wp-json\/wp\/v2\/users\/13258"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/kumarlab\/wp-json\/wp\/v2\/comments?post=2421"}],"version-history":[{"count":24,"href":"https:\/\/sites.bu.edu\/kumarlab\/wp-json\/wp\/v2\/pages\/2421\/revisions"}],"predecessor-version":[{"id":2590,"href":"https:\/\/sites.bu.edu\/kumarlab\/wp-json\/wp\/v2\/pages\/2421\/revisions\/2590"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/kumarlab\/wp-json\/wp\/v2\/media?parent=2421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}