{"id":15,"date":"2015-01-23T10:43:42","date_gmt":"2015-01-23T15:43:42","guid":{"rendered":"https:\/\/sites.bu.edu\/holab\/?page_id=15"},"modified":"2025-07-03T11:41:45","modified_gmt":"2025-07-03T15:41:45","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/holab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Independent Publications as Associate Professor (Angela Ho)
\n<\/strong><\/p>\n

Waxman H, Kankkunen M, Gupta A, Dowgiewicz M, Beffert U, and Ho A<\/strong>\u00a0(2025)\u00a0<\/span>Foxr1<\/i>\u00a0deletion causes microcephaly and leads to cortical and hippocampal hypoplasia. Frontiers in Neuroscience<\/a>.\u00a0<\/span><\/p>\n

Lagani GD, Sha M, Lin W, Natarajan S, Kankkunen M, Kistler SA, Lampl N, Waxman H, Harper ER, Emili A, Beffert U*, Ho A*<\/strong> (2024) Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development. Journal of Neuroscience<\/a>. (*Corresponding authors)<\/p>\n

Gallo CM#<\/sup>, Kistler SA#<\/sup>, Natrakul A, Labadorf AT, Beffert U*, Ho A*<\/strong> (2024) APOER2 splicing repertoire in Alzheimer’s disease: Insights from long-read RNA sequencing. PLOS Genetics<\/a>. \u00a0(#<\/sup>Co-first authors, *Corresponding authors).<\/p>\n

Henry SM, Kistler SA, Lagani GD, Bartling CRO, Ozcelik D, Sereikaite V, Str\u00f8mgaard K, Beffert U*, Ho A*<\/strong> (2023) Tight control of the APP-Mint1 interaction in regulating amyloid production. Brain Research<\/a> (*Corresponding authors)<\/p>\n

Omuro KC, Gallo CM, Scrandis L, Ho A*<\/strong>, Beffert U* (2022) Human APOER2 isoforms have differential cleavage events and synaptic properties. Journal of Neuroscience<\/a>. (*Corresponding authors).<\/p>\n

Gallo CM, Labadorf AT, Ho A*<\/strong>, Beffert U* (2022) Single molecule, long-read Apoer2 sequencing identifies conserved and species-specific splicing patterns. Genomics<\/a>. (*Corresponding authors).<\/a><\/p>\n

Mota A, Waxman HK, Hong R, Lagani GD, Niu S-Y, Bertherat FL, Wolfe L, Malicdan CM, Markello TC, Adams DR, Gahl WA, Cheng CS, Beffert U*, Ho A*<\/strong> (2021) FOXR1 regulates stress response pathways and is necessary for proper brain development. PLOS Genetics<\/a>. (*Corresponding authors).<\/a><\/p>\n

Bartling C*, Jensen T*, Henry S*, Colliander A, Sereikaite V, Wenzler M, Jain P Maric H, Harps\u00f8e K, Pedersen S, Clemmensen L, Haugaard-Kedstroem L, Gloriam D, Ho A<\/strong>, Str\u00f8mgaard K (2021) Targeting the APP-Mint2 protein-protein interaction with a peptide based-inhibitor reduces amyloid-\u03b2 formation. Journal of the American Chemical Society<\/a>. (*Co-first authors).<\/a><\/p>\n

Lee SH#<\/sup>, Kang JK#<\/sup>, Ho A#<\/sup><\/strong>, Watanabe H, Bolshakov VY, Shen J (2020) APP family regulates neuronal excitability and synaptic plasticity but not neuronal survival. Neuron<\/a>, 108:676-690. (#<\/sup>Co-first authors)<\/a><\/p>\n

Gallo CM, Ho A<\/strong>, Beffert U (2020) ApoER2: Functional tuning through splicing. Frontiers in Molecular Neuroscience<\/a>, 13:144.<\/a><\/p>\n

Lin AY, Henry S, Reissner C, Neupert C, Kenny C, Missler M, Beffert U, Ho A<\/strong> (2019) A rare autism-associated MINT2\/APBA2 mutation disrupts neurexin trafficking and synaptic function. Scientific Reports<\/a>, 9:6024.<\/a><\/p>\n

Dillon GM#<\/sup>, Tyler WA#<\/sup>, Omuro KC, Kambouris J, Tyminski C, Henry S, Haydar TF, Beffert U*, Ho A*<\/strong> (2017) CLASP2 links Reelin to the cytoskeleton during neocortical development. Neuron<\/a>, 93:1344-1358.(#<\/sup>Co-first authors, *Corresponding authors). <\/a><\/p>\n

Independent Publications as Assistant Professor (Angela Ho)<\/strong><\/p>\n

Sullivan SE, Dillon GM, Sullivan JM, Ho A<\/strong> (2014) Mint proteins are required for synaptic activity-dependent APP trafficking. Journal of Biological Chemistry<\/a>, 289:15374-15383.<\/a><\/p>\n

Peritore CS, Ho A<\/strong>, Yamamoto BK, Schaus SE (2012) Resveratrol attenuates L-DOPA-induced hydrogen peroxide toxicity in neuronal cells. NeuroReport<\/a>, 23:989-994.<\/a><\/p>\n

Beffert U*, Dillon GM, Sullivan JM, Stuart CE, Gilbert JP, Kambouris JA, Ho A*<\/strong> (2012) Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function. Journal of Neuroscience<\/a>, 32:13906-13916. (*Corresponding authors).<\/a><\/p>\n

Chaufty J#<\/sup>, Sullivan SE#<\/sup>, Ho A<\/strong> (2012) Intracellular amyloid precursor protein sorting and amyloid-beta secretion are regulated by src-mediated phosphorylation of Mint2. Journal of Neuroscience<\/a> 32:9613-9625. (#<\/sup>Co-first authors).<\/a><\/p>\n

Matos MF, Xu Y, Dulubova I, Otwinowski Z, Richardson III JM, Tomchick DR, Rizo J, Ho A<\/strong> (2012) Autoinhibition of Mint1 adaptor protein regulates APP binding and processing. Proceedings of the National Academy Sciences<\/a> 109:3802-3807.<\/a><\/p>\n

Ho A<\/strong> and Shen J (2011) Presenilins in synaptic function and disease. Trends in Molecular Medicine<\/a> 17:617-624.<\/p>\n

<\/a>Publications as Postdoctoral Fellow (Angela Ho)<\/strong><\/p>\n

Zhang D#<\/sup>, Zhang C#<\/sup>, Ho A*<\/strong>, Kirkwood A, S\u00fcdhof TC, Shen J (2010) Inactivation of presenilins causes presynaptic impairment prior to postsynaptic dysfunction. Journal of Neurochemistry<\/a> 115:1215-1221. (#<\/sup>Co-first authors).<\/a><\/p>\n

Mukherjee K, Yang X, Gerber SH, Kwon HB, Ho A<\/strong>, Castillo PE, Liu X, S\u00fcdhof TC (2010) Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis. Proceedings of the National Academy Sciences<\/a> 107:6504-6509.<\/a><\/p>\n

Aoki C, Lee J, Nedelescu H, Ahmed T, Ho A<\/strong>, Shen J (2009) Increased levels of NMDA receptor NR2A subunits at pre- and postsynaptic sites of the hippocampal CA1: an early response to conditional double knockout of presenilin 1 and 2. Journal of Comparative Neurology<\/a> 517:512-523.<\/a><\/p>\n

Ho A*<\/strong>, Liu X, S\u00fcdhof TC* (2008) Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer\u2019s disease. Journal of Neuroscience<\/a> 28:14392-14400. (*Corresponding authors).<\/a><\/p>\n

Atasoy D, Schoch S, Ho A<\/strong>, Nadasy KA, Liu X, Zhang W, Mukherjee K, Nosyreva ED, Fernandez-Chacon R, Missler M, Kavalali ET, S\u00fcdhof TC (2006) Deletion of CASK produces lethality with impaired synaptic function. Proceedings of the National Academy Sciences<\/a> 104:2525-2530.<\/a><\/p>\n

Ho A*<\/strong>, Morishita W, Atasoy D, Liu X, Tabuchi K, Hammer RE, Malenka RC, S\u00fcdhof TC* (2006) Genetic analysis of Mint\/X11 proteins: Essential presynaptic functions of a neuronal adaptor protein family. Journal of Neuroscience<\/a> 26:13089-13101 (*Corresponding authors).<\/a><\/p>\n

Dulubova I, Ho A<\/strong>, Huryeva I, S\u00fcdhof TC, Rizo J (2004) Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein. Biochemistry<\/a> 43:9583-9588.<\/a><\/p>\n

Ho A<\/strong>, S\u00fcdhof TC (2004) Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage. Proceedings of the National Academy Sciences<\/a> 101:2549-2553.<\/a><\/p>\n

Ho A<\/strong>, Morishita W, Hammer RE, Malenka RC, S\u00fcdhof TC (2003) A role of Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proceedings of the National Academy Sciences<\/a> 100:1409-1414.<\/a><\/p>\n

Sugita S, Ho A<\/strong>, S\u00fcdhof TC (2001) NECABs A family of neuronal Ca2+<\/sup>-binding proteins with an unusual domain structure and a restricted expression pattern. Neuroscience<\/a> 112:51-63.<\/a><\/p>\n

Publications as Graduate Student (Angela Ho)<\/strong><\/p>\n

Garcia de Yebenes E, Ho A<\/strong>, Damani T, Fillit H, Blum M (1999) Regulation of the heparin sulfate proteoglycan, perlecan, by injury and interleukin-1 alpha. Journal of Neurochemistry<\/a> 73:812-820.<\/a><\/p>\n

Ho A<\/strong>, Blum M (1998) Induction of interleukin-1 associated with compensatory dopaminergic sprouting in the denervated striatum of young mice: model of aging and neurodegenerative disease. Journal of Neuroscience<\/a> 18:5614-5629.<\/a><\/p>\n

Ho A<\/strong>, Blum M (1997) Regulation of astroglial-derived dopaminergic neurotrophic factor gene expression by interleukin-1\u03b2 in the striatum of young and middle-aged mice. Experimental Neurology<\/a> 148:348-359.<\/a><\/p>\n

Gore AC, Yeo TT, Ho A<\/strong>, Roberts JL (1997) Post-transcriptional regulation of the gonadotropin-releasing hormone gene in GT1-7 cells. Journal of Neuroendocrinology<\/a> 9:271-277.<\/a><\/p>\n

Gore AC, Ho A<\/strong>, Roberts JL (1995) Translational efficiency of gonadotropin-releasing hormone mRNA is negatively regulated by phorbal ester in GT1-7 cells. Endocrinology<\/a> 136:1620-1625.<\/a><\/p>\n

Ho A<\/strong>, Gore AC, Blum M (1995) Glutamate regulation of GDNF gene expression in the striatum and in primary striatal astrocytes. NeuroReport<\/a> 6: 1454-1458.<\/a><\/p>\n

Publications as Research Associate (Angela Ho)<\/strong><\/p>\n

Dalmau J, Graus F, Cheng NK, Rosenblum MK, Ho A<\/strong>, Canete A, Delattre JY, Thompson SJ, Posner JB (1995) Major histocompatibility proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer<\/a> 75:99-109.<\/a><\/p>\n

Walter JC, Dalmau J, Ho A<\/strong>, Posner JB (1994) Analysis of the IgG subclass distribution and inflammatory infiltrates in patients with anti-Hu-associated paraneoplastic encephalomyelitis. Neurology<\/a> 44:140-147.<\/a><\/p>\n

Hormigo A, Dalmau J, Rosenblum M, Ho A<\/strong>, River ME, Morrison JM, Posner JB (1993) Immunological and pathological study of a patient with anti-R1-associated encephalopathy. Annals of Neurology 34: 278.<\/p>\n","protected":false},"excerpt":{"rendered":"

Independent Publications as Associate Professor (Angela Ho) Waxman H, Kankkunen M, Gupta A, Dowgiewicz M, Beffert U, and Ho A\u00a0(2025)\u00a0Foxr1\u00a0deletion causes microcephaly and leads to cortical and hippocampal hypoplasia. Frontiers in Neuroscience.\u00a0 Lagani GD, Sha M, Lin W, Natarajan S, Kankkunen M, Kistler SA, Lampl N, Waxman H, Harper ER, Emili A, Beffert U*, Ho […]<\/p>\n","protected":false},"author":9868,"featured_media":0,"parent":0,"menu_order":5,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/holab\/wp-json\/wp\/v2\/pages\/15"}],"collection":[{"href":"https:\/\/sites.bu.edu\/holab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/holab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/holab\/wp-json\/wp\/v2\/users\/9868"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/holab\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":50,"href":"https:\/\/sites.bu.edu\/holab\/wp-json\/wp\/v2\/pages\/15\/revisions"}],"predecessor-version":[{"id":785,"href":"https:\/\/sites.bu.edu\/holab\/wp-json\/wp\/v2\/pages\/15\/revisions\/785"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/holab\/wp-json\/wp\/v2\/media?parent=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}