Publications
Independent Publications as Associate Professor (Angela Ho)
Lagani GD, Sha M, Lin W, Natarajan S, Kankkunen M, Kistler SA, Lampl N, Waxman H, Harper ER, Emili A, Beffert U*, Ho A* (2024) Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development. Journal of Neuroscience. (*Corresponding authors)
Gallo CM#, Kistler SA#, Natrakul A, Labadorf AT, Beffert U*, Ho A* (2024) APOER2 splicing repertoire in Alzheimer’s disease: Insights from long-read RNA sequencing. PLOS Genetics. (#Co-first authors, *Corresponding authors).
Henry SM, Kistler SA, Lagani GD, Bartling CRO, Ozcelik D, Sereikaite V, Strømgaard K, Beffert U*, Ho A* (2023) Tight control of the APP-Mint1 interaction in regulating amyloid production. Brain Research (*Corresponding authors)
Omuro KC, Gallo CM, Scrandis L, Ho A*, Beffert U* (2022) Human APOER2 isoforms have differential cleavage events and synaptic properties. Journal of Neuroscience. (*Corresponding authors).
Gallo CM, Labadorf AT, Ho A*, Beffert U* (2022) Single molecule, long-read Apoer2 sequencing identifies conserved and species-specific splicing patterns. Genomics. (*Corresponding authors).
Mota A, Waxman HK, Hong R, Lagani GD, Niu S-Y, Bertherat FL, Wolfe L, Malicdan CM, Markello TC, Adams DR, Gahl WA, Cheng CS, Beffert U*, Ho A* (2021) FOXR1 regulates stress response pathways and is necessary for proper brain development. PLOS Genetics. (*Corresponding authors).
Bartling C*, Jensen T*, Henry S*, Colliander A, Sereikaite V, Wenzler M, Jain P Maric H, Harpsøe K, Pedersen S, Clemmensen L, Haugaard-Kedstroem L, Gloriam D, Ho A, Strømgaard K (2021) Targeting the APP-Mint2 protein-protein interaction with a peptide based-inhibitor reduces amyloid-β formation. Journal of the American Chemical Society. (*Co-first authors).
Lee SH#, Kang JK#, Ho A#, Watanabe H, Bolshakov VY, Shen J (2020) APP family regulates neuronal excitability and synaptic plasticity but not neuronal survival. Neuron, 108:676-690. (#Co-first authors)
Gallo CM, Ho A, Beffert U (2020) ApoER2: Functional tuning through splicing. Frontiers in Molecular Neuroscience, 13:144.
Lin AY, Henry S, Reissner C, Neupert C, Kenny C, Missler M, Beffert U, Ho A (2019) A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function. Scientific Reports, 9:6024.
Dillon GM#, Tyler WA#, Omuro KC, Kambouris J, Tyminski C, Henry S, Haydar TF, Beffert U*, Ho A* (2017) CLASP2 links Reelin to the cytoskeleton during neocortical development. Neuron, 93:1344-1358.(#Co-first authors, *Corresponding authors).
Independent Publications as Assistant Professor (Angela Ho)
Sullivan SE, Dillon GM, Sullivan JM, Ho A (2014) Mint proteins are required for synaptic activity-dependent APP trafficking. Journal of Biological Chemistry, 289:15374-15383.
Peritore CS, Ho A, Yamamoto BK, Schaus SE (2012) Resveratrol attenuates L-DOPA-induced hydrogen peroxide toxicity in neuronal cells. NeuroReport, 23:989-994.
Beffert U*, Dillon GM, Sullivan JM, Stuart CE, Gilbert JP, Kambouris JA, Ho A* (2012) Microtubule plus-end tracking protein CLASP2 regulates neuronal polarity and synaptic function. Journal of Neuroscience, 32:13906-13916. (*Corresponding authors).
Chaufty J#, Sullivan SE#, Ho A (2012) Intracellular amyloid precursor protein sorting and amyloid-beta secretion are regulated by src-mediated phosphorylation of Mint2. Journal of Neuroscience 32:9613-9625. (#Co-first authors).
Matos MF, Xu Y, Dulubova I, Otwinowski Z, Richardson III JM, Tomchick DR, Rizo J, Ho A (2012) Autoinhibition of Mint1 adaptor protein regulates APP binding and processing. Proceedings of the National Academy Sciences 109:3802-3807.
Ho A and Shen J (2011) Presenilins in synaptic function and disease. Trends in Molecular Medicine 17:617-624.
Publications as Postdoctoral Fellow (Angela Ho)
Zhang D#, Zhang C#, Ho A*, Kirkwood A, Südhof TC, Shen J (2010) Inactivation of presenilins causes presynaptic impairment prior to postsynaptic dysfunction. Journal of Neurochemistry 115:1215-1221. (#Co-first authors).
Mukherjee K, Yang X, Gerber SH, Kwon HB, Ho A, Castillo PE, Liu X, Südhof TC (2010) Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis. Proceedings of the National Academy Sciences 107:6504-6509.
Aoki C, Lee J, Nedelescu H, Ahmed T, Ho A, Shen J (2009) Increased levels of NMDA receptor NR2A subunits at pre- and postsynaptic sites of the hippocampal CA1: an early response to conditional double knockout of presenilin 1 and 2. Journal of Comparative Neurology 517:512-523.
Ho A*, Liu X, Südhof TC* (2008) Deletion of Mint proteins decreases amyloid production in transgenic mouse models of Alzheimer’s disease. Journal of Neuroscience 28:14392-14400. (*Corresponding authors).
Atasoy D, Schoch S, Ho A, Nadasy KA, Liu X, Zhang W, Mukherjee K, Nosyreva ED, Fernandez-Chacon R, Missler M, Kavalali ET, Südhof TC (2006) Deletion of CASK produces lethality with impaired synaptic function. Proceedings of the National Academy Sciences 104:2525-2530.
Ho A*, Morishita W, Atasoy D, Liu X, Tabuchi K, Hammer RE, Malenka RC, Südhof TC* (2006) Genetic analysis of Mint/X11 proteins: Essential presynaptic functions of a neuronal adaptor protein family. Journal of Neuroscience 26:13089-13101 (*Corresponding authors).
Dulubova I, Ho A, Huryeva I, Südhof TC, Rizo J (2004) Three-dimensional structure of an independently folded extracellular domain of human amyloid-beta precursor protein. Biochemistry 43:9583-9588.
Ho A, Südhof TC (2004) Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage. Proceedings of the National Academy Sciences 101:2549-2553.
Ho A, Morishita W, Hammer RE, Malenka RC, Südhof TC (2003) A role of Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proceedings of the National Academy Sciences 100:1409-1414.
Sugita S, Ho A, Südhof TC (2001) NECABs A family of neuronal Ca2+-binding proteins with an unusual domain structure and a restricted expression pattern. Neuroscience 112:51-63.
Publications as Graduate Student (Angela Ho)
Garcia de Yebenes E, Ho A, Damani T, Fillit H, Blum M (1999) Regulation of the heparin sulfate proteoglycan, perlecan, by injury and interleukin-1 alpha. Journal of Neurochemistry 73:812-820.
Ho A, Blum M (1998) Induction of interleukin-1 associated with compensatory dopaminergic sprouting in the denervated striatum of young mice: model of aging and neurodegenerative disease. Journal of Neuroscience 18:5614-5629.
Ho A, Blum M (1997) Regulation of astroglial-derived dopaminergic neurotrophic factor gene expression by interleukin-1β in the striatum of young and middle-aged mice. Experimental Neurology 148:348-359.
Gore AC, Yeo TT, Ho A, Roberts JL (1997) Post-transcriptional regulation of the gonadotropin-releasing hormone gene in GT1-7 cells. Journal of Neuroendocrinology 9:271-277.
Gore AC, Ho A, Roberts JL (1995) Translational efficiency of gonadotropin-releasing hormone mRNA is negatively regulated by phorbal ester in GT1-7 cells. Endocrinology 136:1620-1625.
Ho A, Gore AC, Blum M (1995) Glutamate regulation of GDNF gene expression in the striatum and in primary striatal astrocytes. NeuroReport 6: 1454-1458.
Publications as Research Associate (Angela Ho)
Dalmau J, Graus F, Cheng NK, Rosenblum MK, Ho A, Canete A, Delattre JY, Thompson SJ, Posner JB (1995) Major histocompatibility proteins, anti-Hu antibodies, and paraneoplastic encephalomyelitis in neuroblastoma and small cell lung cancer. Cancer 75:99-109.
Walter JC, Dalmau J, Ho A, Posner JB (1994) Analysis of the IgG subclass distribution and inflammatory infiltrates in patients with anti-Hu-associated paraneoplastic encephalomyelitis. Neurology 44:140-147.
Hormigo A, Dalmau J, Rosenblum M, Ho A, River ME, Morrison JM, Posner JB (1993) Immunological and pathological study of a patient with anti-R1-associated encephalopathy. Annals of Neurology 34: 278.