{"id":5,"date":"2020-01-24T16:04:41","date_gmt":"2020-01-24T21:04:41","guid":{"rendered":"https:\/\/sites.bu.edu\/heaphylab\/heaphy-lab\/"},"modified":"2025-12-30T11:18:29","modified_gmt":"2025-12-30T16:18:29","slug":"heaphy-lab","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/heaphylab\/","title":{"rendered":"Heaphy Lab"},"content":{"rendered":"<div class=\"bu-slideshow-container home-page autoplay\" id=\"bu-slideshow-container-50\" data-slideshow-name=\"home-page\" data-slideshow-delay=\"3000\" style=\"width: auto; \"><div class='slideshow-loader active'><div class='loader-animation'><\/div><p>loading slideshow...<\/p><\/div><div class=\"bu-slideshow-slides\"><ul class=\"bu-slideshow transition-slide\" id=\"bu-slideshow-50\"><li id=\"bu-slideshow-50_0\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-left\"><img src=\"\/heaphylab\/files\/2023\/11\/NatRevUrol.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-left\"><p class=\"bu-slide-caption-title\">Senescent fibroblasts<\/p><p class=\"bu-slide-caption-text\">Senescent fibroblasts can accumulate and produce senescence-associated secretory phenotype (SASP).<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_1\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-left\"><img src=\"\/heaphylab\/files\/2020\/04\/Retina-foci.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-left\"><p class=\"bu-slide-caption-title\">Photoreceptors<\/p><p class=\"bu-slide-caption-text\">Telomere-specific FISH with colabeling for cone nuclei and processes (green) and rod nuclei (magenta) <\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_2\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-center\"><img src=\"\/heaphylab\/files\/2023\/10\/ALT-mechanism-copy.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-center\"><p class=\"bu-slide-caption-title\">ALT mechanism<\/p><p class=\"bu-slide-caption-text\">Break-induced replication mediates the extension of ALT telomeres<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_3\" class=\"slide \"><div class=\"bu-slide-container slide-caption-top-right\"><img src=\"\/heaphylab\/files\/2020\/04\/prostate-TMA-right-size-1.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-top-right\"><p class=\"bu-slide-caption-title\">Prostate Cancer TMA<\/p><p class=\"bu-slide-caption-text\">Telomere-specific FISH with costaining for a basal-specific cytokeratin (magenta) as well as NKX3.1 and FOXA1 (green) <\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_4\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-left\"><img src=\"\/heaphylab\/files\/2020\/04\/Breast-TDLU-1024x765.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-left\"><p class=\"bu-slide-caption-title\">Breast TDLU<\/p><p class=\"bu-slide-caption-text\">Telomere and centromere-specific FISH with costaining for smooth muscle actin (magenta) and Ki67 (turquoise)<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_5\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/heaphylab\/files\/2020\/04\/ALT-PanNET-1.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-right\"><p class=\"bu-slide-caption-title\">ALT+ PanNET<\/p><p class=\"bu-slide-caption-text\">Telomere-specific (red) and centromere-specific (green) FISH denotes the presence of ALT<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_6\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-center\"><img src=\"\/heaphylab\/files\/2023\/10\/PanNET-model.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-center\"><p class=\"bu-slide-caption-title\">Proposed PanNET model<\/p><p class=\"bu-slide-caption-text\">Multistep tumorigenesis of sporadic non-functional PanNETs<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_7\" class=\"slide \"><div class=\"bu-slide-container slide-caption-top-right\"><img src=\"\/heaphylab\/files\/2026\/03\/Picture1.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-top-right\"><p class=\"bu-slide-caption-title\">Lunaphore COMET<\/p><p class=\"bu-slide-caption-text\">mIF (pan-CK &amp; CD56) in PanNETs<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_8\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/heaphylab\/files\/2023\/10\/Capture.jpg\" alt=\"\" \/><\/div><\/li><li id=\"bu-slideshow-50_9\" class=\"slide \"><div class=\"bu-slide-container slide-caption-top-right\"><img src=\"\/heaphylab\/files\/2024\/05\/Small-intestine-Ki67Lamin-AC-1024x750.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-top-right\"><p class=\"bu-slide-caption-title\">Ki67 in small intestine<\/p><p class=\"bu-slide-caption-text\">Ki67 (red) and lamin A\/C (green) IF<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_10\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/heaphylab\/files\/2020\/04\/lamin.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-right\"><p class=\"bu-slide-caption-title\">Lamin A\/C in PrCa<\/p><p class=\"bu-slide-caption-text\">Costaining for a lamin A\/C (green) and cytokeratin 8 in a prostate cancer<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_11\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/heaphylab\/files\/2024\/03\/PanNET-biomarkers.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-right\"><p class=\"bu-slide-caption-title\">PanNET biomarkers<\/p><p class=\"bu-slide-caption-text\">Established tissue-based prognostic biomarkers for non-functional pancreatic neuroendocrine tumors.<\/p><\/div><\/div><\/li><li id=\"bu-slideshow-50_12\" class=\"slide \"><div class=\"bu-slide-container slide-caption-bottom-right\"><img src=\"\/heaphylab\/files\/2023\/10\/TeloCISH.jpg\" alt=\"\" \/><div class=\"bu-slide-caption caption-bottom-right\"><p class=\"bu-slide-caption-title\">Telo-CISH<\/p><p class=\"bu-slide-caption-text\">Telo-CISH multiplex with basal-specific cytokeratin facilitates easy identification of short telomeres<\/p><\/div><\/div><\/li><\/ul><\/div><div class=\"bu-slideshow-navigation-container\"><ul class=\"bu-slideshow-navigation nav-icon\" id=\"bu-slideshow-nav-50\" aria-hidden=\"true\"><li><a href=\"#\" id=\"pager-1\" class=\" active\" aria-hidden=\"true\"><span>1<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-2\" class=\"\" aria-hidden=\"true\"><span>2<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-3\" class=\"\" aria-hidden=\"true\"><span>3<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-4\" class=\"\" aria-hidden=\"true\"><span>4<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-5\" class=\"\" aria-hidden=\"true\"><span>5<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-6\" class=\"\" aria-hidden=\"true\"><span>6<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-7\" class=\"\" aria-hidden=\"true\"><span>7<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-8\" class=\"\" aria-hidden=\"true\"><span>8<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-9\" class=\"\" aria-hidden=\"true\"><span>9<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-10\" class=\"\" aria-hidden=\"true\"><span>10<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-11\" class=\"\" aria-hidden=\"true\"><span>11<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-12\" class=\"\" aria-hidden=\"true\"><span>12<\/span><\/a><\/li> <li><a href=\"#\" id=\"pager-13\" class=\"\" aria-hidden=\"true\"><span>13<\/span><\/a><\/li> <\/ul><\/div><\/div>\n<p style=\"text-align: justify;\"><strong><span style=\"color: #ff0000;\">HEAPHY LAB MISSION<\/span><\/strong><\/p>\n<p style=\"text-align: justify;\">The <strong>Heaphy Lab<\/strong> applies an integrated, multidisciplinary approach, which combines tissue-level analysis, cell-based modeling, and molecular and spatial profiling technologies, to define how telomere dysfunction drives the initiation and progression of\u00a0 cancer. Our work spans pancreatic neuroendocrine tumors, prostate cancer, breast cancer, sarcomas, and gliomas.<\/p>\n<p style=\"text-align: justify;\">We aim to translate fundamental discoveries in tumor and tumor microenvironment (TME) biology into clinically actionable biomarkers and strategies that improve cancer risk stratification, prognostication, and therapeutic decision-making.<\/p>\n<p style=\"text-align: justify;\">Equally central to our mission is fostering a rigorous, collaborative, and inclusive laboratory culture. We are deeply committed to mentoring and supporting the professional and personal development of every lab member, empowering the pursuit of impactful, independent, and team-driven research.<\/p>\n<p><img loading=\"lazy\" src=\"\/heaphylab\/files\/2022\/02\/Heaphy-lab-636x456.jpg\" alt=\"\" width=\"636\" height=\"456\" class=\"size-medium wp-image-508 aligncenter\" srcset=\"https:\/\/sites.bu.edu\/heaphylab\/files\/2022\/02\/Heaphy-lab-636x456.jpg 636w, https:\/\/sites.bu.edu\/heaphylab\/files\/2022\/02\/Heaphy-lab-1024x733.jpg 1024w, https:\/\/sites.bu.edu\/heaphylab\/files\/2022\/02\/Heaphy-lab-768x550.jpg 768w, https:\/\/sites.bu.edu\/heaphylab\/files\/2022\/02\/Heaphy-lab-1536x1100.jpg 1536w, https:\/\/sites.bu.edu\/heaphylab\/files\/2022\/02\/Heaphy-lab-2048x1467.jpg 2048w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><\/p>\n","protected":false},"excerpt":{"rendered":"<p>HEAPHY LAB MISSION The Heaphy Lab applies an integrated, multidisciplinary approach, which combines tissue-level analysis, cell-based modeling, and molecular and spatial profiling technologies, to define how telomere dysfunction drives the initiation and progression of\u00a0 cancer. Our work spans pancreatic neuroendocrine tumors, prostate cancer, breast cancer, sarcomas, and gliomas. We aim to translate fundamental discoveries in [&hellip;]<\/p>\n","protected":false},"author":17342,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/pages\/5"}],"collection":[{"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/users\/17342"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/comments?post=5"}],"version-history":[{"count":25,"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/pages\/5\/revisions"}],"predecessor-version":[{"id":1165,"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/pages\/5\/revisions\/1165"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/media?parent=5"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}