{"id":32,"date":"2020-04-21T13:27:26","date_gmt":"2020-04-21T17:27:26","guid":{"rendered":"https:\/\/sites.bu.edu\/heaphylab\/?page_id=32"},"modified":"2026-03-28T10:34:41","modified_gmt":"2026-03-28T14:34:41","slug":"publications","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/heaphylab\/publications\/","title":{"rendered":"Publications"},"content":{"rendered":"

Current preprints<\/em><\/h2>\n

Song H, Xu J, Velazquez-Arcelay K, Demirci A, Raizenne BL, Hsu SC, Choi J, Pham JH, Chen Y, Weinstein HNW, Salzman I, Tsui M, Akutagawa J, Adingo W, Goldschmidt E, Carroll PR, Hong JC, Heaphy CM, Cooperberg MR, Greenland N, Campbell JD, Huang FW. A single-cell and spatial atlas of prostate cancer reveals the combinatorial nature of gene modules underlying lineage plasticity and metastasis.<\/strong> bioRxiv <\/em><\/span>2026 https:\/\/www.biorxiv.org\/content\/10.64898\/2026.03.25.711335v1<\/a><\/span><\/span><\/span><\/span><\/span><\/p>\n

Keegan J<\/span><\/span>, Sorbello S<\/span><\/span>, Mori J<\/span><\/span>, Muratani S<\/span><\/span>, Leshchiner I<\/span><\/span>, Heaphy CM<\/span><\/span>, Flynn RL.<\/span> Functional inactivation of the telomerase chaperone TCAB1 primes cells for the activation of ALT in osteosarcoma.<\/span><\/strong><\/span>\u00a0<\/span> bioRxiv <\/em><\/span>2026<\/span> https:\/\/doi.org\/10.64898\/2026.01.02.691864<\/a><\/span><\/span><\/span><\/span><\/p>\n

Sheridan JP<\/span><\/span>,\u00a0Sun Q<\/span><\/span>,\u00a0Chen JG<\/span><\/span>,\u00a0Wei Y<\/span><\/span>,\u00a0Jarzabek V<\/span><\/span>,\u00a0Jaishankar A<\/span><\/span>,\u00a0Amin I<\/span><\/span>,\u00a0Sultan L<\/span><\/span>,\u00a0Nalan T<\/span><\/span>,\u00a0Mueller SB<\/span><\/span>, Burks EJ,<\/span><\/span>\u00a0Suaiti L<\/span><\/span>, Heaphy CM<\/span><\/span>,\u00a0Ko NY<\/span><\/span>,\u00a0<\/span>Dries R.<\/span>\u00a0Clinical feasibility of spatial transcriptomics using discarded tissue from diagnostic breast biopsies. <\/strong><\/span>bioRxiv <\/em><\/span>2026 https:\/\/doi.org\/10.64898\/2025.12.30.696765<\/a><\/span><\/span><\/span><\/span><\/span><\/span><\/p>\n

Mori JO, Da J, Kim J, <\/sup>Rizzo A, Davis C, Lanza C, Brosnan-Cashman JA, Meeker AK, Heaphy CM, Graham MK.<\/span> Loss of DAXX induces alternative lengthening of telomeres (ALT)-associated hallmarks in prostate cancer cells in a context-specific manner<\/strong>.<\/span> bioRxiv <\/em><\/span>2025<\/span> https:\/\/doi.org\/10.1101\/2025.08.06.668744<\/a>\u00a0<\/span><\/span><\/p>\n

<\/span><\/span><\/span><\/span><\/p>\n

In pre<\/em>ss<\/em><\/h2>\n

Arbesfeld-Qiu JM, Cho JW, Nguyen PTT, Lester NA, Su J, Shiau C, Guo JA, Hoffman H, Caldwell N, Muratani S, Galvan M, Proctor JE, Ely Z, Wang S, Ganci M, Dries R, Hong T, Wo J, Boland G, Fernandez-Del Castillo C, Ferrone CR,\u00a0<\/strong><\/span>Heaphy CM, Zhang ML, Mino-Kenudson M, Hemberg M, Hwang WL.<\/span> Distinct malignant cell states and myeloid glutamate signaling associated with aggressive pancreatic neuroendocrine tumors.<\/strong><\/span> Clinical Cancer Research\u00a0<\/em><\/span>2026<\/span> doi: 10.1158\/1078-0432.CCR-25-2565<\/span><\/span><\/a><\/p>\n

2026<\/h2>\n

None currently<\/p>\n

2025<\/h2>\n

Wood-Trageser MA, Nichols CT, Hutchings DA, Bell D, Wald AI, Smith K, Hong SM, Luchini C, Brosens LAA, Verschuur AVD, Bevere M, Lawlor RT, Scarpa A, Keating S, Tucker J, O’Sullivan RJ, Liu TC, McGrath K, Fasanella K, Brand RE, Lennon AM, Das R, Singh H, Slivka A, Mahmood S, Hosmer AE, Khalid A, Romutis SL, Zureikat AH, Zeh HJ, Hogg ME, Lee KK, Paniccia A, Nunns G, Ongchin M, Park WG, Polanco PM, He J, Simeone DM, Ferrone CR, Hsu D, Zhang J, Gorantla V, Rhee J, Hruban RH, Singhi AH, Singhi SA, Wang CK, Shaker N, Bubar R, Grupillo M, Lai YT, Nikiforova MN,\u00a0Heaphy CM, Waters KM, Singhi AD. Recurrent BEND2 fusion genes identified by whole transcriptome sequencing of non-functional pancreatic neuroendocrine tumors correlate with poor patient prognosis<\/strong>. Modern Pathology<\/em> <\/span>2025 38:100863.<\/span><\/a> (Neuroendocrine Tumor Research Foundation News)<\/a> (OncoDaily<\/a>)<\/span><\/strong><\/em><\/span><\/span><\/span><\/p>\n

Puzzuoli JC, Solivio C, Yuan G, Rizzo AJ, Graham MK, Shenker L, Vista WR, Gil A, Singh H, Alexander E, Gonzalez A, Latzman J, Petre EN, Yarmohammadi H, Erinjeri JP, Covey A, Chan E, Russell J, Bodei L, Raj N, Reidy-Lagunes D, Heaphy CM, Ziv E. Loss of DAXX or ATRX protein expression results in ischemia resistance and radiation sensitivity in pancreatic neuroendocrine tumor cell lines and is associated with improved response to trans-arterial radio-embolization<\/strong>. Neuroendocrinology<\/em><\/span> 2025;115:730-40.<\/a><\/span><\/p>\n

Heaphy CM, Patel S, Smith K, Wondisford AR, Lynskey ML, O’Sullivan RJ, Fuhrer K, Han X, Seethala RR, Liu TC, Cao D, Ertunc O, Zheng Q, Stojanova M, Zureikat AH, Paniccia A, Lee K, Ongchin MC, Pingpank JF, Zeh HJ, Hogg ME, Geller D, Marsh JW, Brand RE, Chennat JS, Das R, Fasanella KE, Gabbert C, Khalid A, McGrath K, Lennon AM, Sarkaria S, Singh H, Slivka A, Hsu D, Zhang JY, Nacev BA, Nikiforova MN, Wald AI, Vaddi N, De Marzo AM, Singhi AH, Bell PD, Singhi AD.<\/span> Alternative Lengthening of Telomeres detection via chromogenic in situ<\/em> hybridization (ALT-CISH) for the prognostication of pancreatic neuroendocrine tumors and other neoplasms.<\/strong> Modern Pathology<\/em><\/span> 2025;38:1006511.<\/span><\/a> (Highlighted by the Neuroendocrine Tumor Research Foundation)<\/span><\/strong><\/a><\/p>\n

Belakhoua S, Lopez G, Dubey S, Rai S, Chen L, Chen S, Pallavajjala A, Yuan M, Pekmezci M, Stojanova M, Heaphy CM, Eberhart CG, Rodriguez FJ. RECQL4<\/em> alterations in gliomas and nerve sheath tumors: expression patterns and therapeutic implications.<\/strong> Journal of Neuropathology & Experimental Neurology<\/span> <\/em>2025;84:1191-201.<\/a><\/span><\/p>\n

Verschuur AVD, Chen L, Nieveen van Dijkum EJ, Luchini C, Halfdanarson TR, Hong SM, Singhi AD, Brosens LAA, Heaphy CM. Management of patients with small pancreatic neuroendocrine tumors from a biomarker and surgical perspective.<\/strong> Endocrine-Related Cancer<\/em><\/span> 2025;32:e240305.<\/a> (Invited Review) (Highlighted by the Neuroendocrine Tumor Research Foundation)<\/a><\/span><\/strong><\/em><\/span><\/span><\/span><\/p>\n

2024<\/h2>\n

Mori JO, Elhussin I, Brennen WN, Graham MK, Lotan TL, Yates CC, De Marzo AM, Denmeade SR, Yegnasubramanian S, Nelson WG, Denis GV, Platz EA, Meeker AK, Heaphy CM. Senescent stromal fibroblasts as potential prognostic and therapeutic targets in prostate cancer.<\/strong> Nature Reviews Urology<\/em><\/span> 2024;21-258-73.<\/span><\/a> (Invited Review)<\/strong><\/em><\/span><\/span><\/p>\n

Pinto L, Pailas A, Bondarchenko M, Sharma A, Neumann K, Rizzo AJ, Jeanty C, Nicot N, Racca C, Graham MK, Naughton C, Liu Y, Chen C, Meakin P, Gilbert N, Britton S, Meeker AK, Heaphy CM, Larminat F, Van Dyck E. DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks.<\/strong> Nucleic Acids Research<\/span> <\/em>2024;52:1136-55.<\/span><\/a> (Press Release)<\/strong><\/em><\/span><\/a><\/span><\/p>\n

Mori JO, Keegan J, Flynn RL, Heaphy CM. Alternative Lengthening of Telomeres: mechanism and the pathogenesis of cancer. <\/strong>Journal of Clinical Pathology <\/em>2024;77:82-6<\/span><\/a>.<\/span> (Molecules in Pathogenesis)<\/strong><\/span><\/span><\/i><\/span><\/em><\/span><\/span><\/p>\n

Ertunc<\/span> O,\u00a0Smearman E<\/span>,\u00a0<\/span>Zheng Q<\/span>,\u00a0<\/span>Hicks JL<\/span>,\u00a0Brosnan-Cashman JA<\/span>,\u00a0Jones T<\/span>,\u00a0Gomes-Alexandre C<\/span>, Trabzonlu L<\/span>,\u00a0Meeker AK, De Marzo AM, Heaphy CM. <\/span>Chromogenic detection of telomere lengths in situ aids the identification of precancerous lesions in the prostate.<\/strong>\u00a0<\/span>The Prostate<\/i> 2024;84:148-57.<\/a><\/span><\/span><\/span><\/span><\/p>\n

Graham MK, Xu B, Davis C, Meeker AK, Heaphy CM, Yegnasubramanian S, Dyer MA, Zeineldin M. The TERT promoter is polycomb-repressed in neuroblastoma cells with long telomeres. <\/strong>Cancer Research Communications<\/em><\/span> 2024;4:1533-47.<\/a><\/span><\/span><\/p>\n

Sung YN, Stojanova M, Shin S, Cho HJ, Heaphy CM, Hong SM. Gradual telomere shortening in the tumorigenesis of pancreatic and hepatic mucinous cystic neoplasms.<\/strong> Human Pathology<\/em><\/span> 2024;152:105653.<\/a><\/span><\/p>\n

Mori JO, Platz EA, Lu J, Brame A, Han M, Joshu CE, De Marzo AM, Meeker AK, Heaphy CM. Longer prostate stromal cell telomere length is associated with increased risk of death from other cancers<\/strong>. Frontiers in Medicine <\/em><\/span>2024;11:1390769.<\/a><\/span><\/p>\n

2023<\/h2>\n

Low JY, Ko M, Hanratty B, Patel RA, Bhamidipati A, Heaphy CM, Sayar E, Lee JK, Li S, De Marzo AM, Nelson WG, Gupta A, Yegnasubramanian S, Ha G, Epstein JI, Haffner MC. Genomic characterization of prostatic basal cell carcinoma.<\/strong> American Journal of Pathology<\/em><\/span> 2023;193:4-10.<\/a><\/span> (Journal Cover)<\/strong><\/span><\/a> (Fred Hutch Science Spotlight)<\/strong><\/span><\/a> (OncLive interview with Dr. Michael Haffner)<\/strong><\/span><\/a><\/em><\/p>\n

Heaphy CM, Singhi AD. Reprint of:<\/strong><\/em> The diagnostic and prognostic utility of incorporating DAXX, ATRX, and Alternative Lengthening of Telomeres (ALT) to the evaluation of Pancreatic Neuroendocrine Tumors (PanNETs). <\/strong>Human Pathology<\/em><\/span>\u00a02023;132:1-11.<\/a> <\/span>(Invited Review)<\/strong><\/em><\/span><\/p>\n

Neyaz A, Crotty R, Rickelt S, Pankaj A, Stojanova M, Michelakos TP, Sekigami Y, Kontos F, Parrack PH, Patil DT, Heaphy CM, Ferrone CR, Deshpande V. Predicting recurrence in Pancreatic Neuroendocrine Tumours: Role of ARX and Alternative Lengthening of Telomeres (ALT)<\/strong>. Histopathology <\/em><\/span>2023;83:546-58<\/a>.<\/span><\/p>\n

2022<\/h2>\n

Hackeng WM, Brosens LAA, Kim JY, O\u2019Sullivan RJ, Sung Y, Liu T, Cao D, Heayn M, Brosnan-Cashman JA, An D, Morsink FHM, Heidsma CM, Valk GD, Vriens MR, Nieveen van Dijkum EJM, Offerhaus GJA, Dreijerink KMA, Zeh HJ, Zureikat AH, Hogg ME, Lee K, Geller D, Marsh JW, Paniccia A, Ongchin MC, Pingpank JF, Bahary N, Aijazi M, Brand RE, Chennat JS, Das R, Fasanella KE, Khalid A, McGrath K, Sarkaria S, Singh H, Slivka A, Nalesnik MA, Han X, Nikiforova MN, Lawlor RT, Mafficini A, Rusev B, Corbo V, Luchini C, Bersani S, Pea A, Cingarlini S, Landoni L, Salvia R, Milione M, Milella M, Scarpa A, Hong SM, Heaphy CM, Singhi AD. Non-functional pancreatic neuroendocrine tumours: ATRX\/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX\/PDX1 expression and tumour size.<\/strong> Gut<\/em><\/span> 2022;71:961-73.<\/a> <\/span>(Accompanying Editorial)<\/strong><\/em><\/span><\/a> (Reviewed in Current Oncology Reports)<\/strong><\/span><\/a> (Identified by the 20th Annual ENETS Conference 2023 as top article)<\/strong><\/a><\/span><\/em><\/p>\n

Dreijerink KMA, Hackeng WM, Singhi AD, Heaphy CM, Brosens LAA. Clinical implications of cell-of-origin epigenetic\u00a0characteristics\u00a0in\u00a0non-functional\u00a0pancreatic neuroendocrine tumors.<\/strong> Journal of Pathology <\/em><\/span>2022;256:143-8.<\/a> <\/span>(Invited Review)<\/em><\/strong><\/span><\/a><\/p>\n

Jafari N, Chen A, Kolla M, Pompa IR, Qiu Y, Yu R, Llevenes P, Ennis CS, Mori J, Mahdaviani K, Halpin M, Gignac GA, Heaphy CM, Monti S, Denis GV. Novel plasma exosome biomarkers for prostate cancer progression in co-morbid metabolic disease. <\/strong>Advances in Cancer Biology \u2013 Metastasis<\/em><\/span> 2022;6:100073.<\/a><\/span><\/p>\n

Hackeng WM, Assi HA, Westerbeke FHM, Brosens LAA, Heaphy CM. Prognostic and predictive biomarkers for pancreatic neuroendocrine tumors.<\/strong> Surgical Pathology Clinics<\/em><\/span> 2022;15:541-54.<\/a> <\/span>(Invited Review)<\/strong><\/em><\/span><\/p>\n

Heaphy CM, Joshu CE, Barber JR, Davis C,Lu J, Zarinshenas R, Giovannucci E, Mucci LA, Stampfer MJ, Han M, De Marzo AM, Lotan TL, Platz EA, Meeker AK. The prostate tissue-based telomere biomarker as a prognostic tool for metastasis and death from prostate cancer after prostatectomy. <\/span><\/strong>Journal of Pathology: Clinical Research <\/em><\/span>2022;8:481-91.<\/a><\/span><\/p>\n

Heaphy CM, Singhi AD. The diagnostic and prognostic utility of incorporating DAXX, ATRX, and Alternative Lengthening of Telomeres (ALT) to the evaluation of Pancreatic Neuroendocrine Tumors (PanNETs). <\/strong>Human Pathology<\/em><\/span>\u00a02022;129:11-20.<\/a> <\/span>(Invited Review)<\/strong><\/em><\/span><\/p>\n

Yuan M, Eberhart CG, Pratilas CA, Blakeley J, Davis C, Stojanova M, Reilly K, Meeker AK, Heaphy CM, Rodriguez FJ. Therapeutic vulnerability to ATR inhibition in concurrent NF1 and ATRX-deficient high-grade solid tumors.<\/strong> Cancers <\/span><\/em>2022;14:3015.<\/a><\/span><\/span><\/p>\n

Mori JO, Shafran JS, Stojanova M, Katz MH, Gignac GA, Wisco JJ, Heaphy CM, Denis GV. Novel forms of prostate cancer chemoresistance to successful androgen deprivation therapy demand new approaches: Rationale for targeting BET proteins.<\/strong> The Prostate<\/em><\/span> 2022;82:1005-15<\/a>.<\/span> (Review)<\/strong><\/em><\/span><\/p>\n

Lally SE, Milman T, Dalvin LA, Orloff M, Eberhart CG, Heaphy CM, Rodriguez FJ, Lin CC, Dockery PW, Shields JA, Shields CL. Mutational landscape and outcomes of conjunctival melanoma in 101 patients.<\/strong> Ophthalmology<\/em><\/span> 2022;129:679-93.<\/a><\/span><\/p>\n

Heaphy CM, Zarinshenas R, Barber JR, Davis C,\u00a0Brosnan-Cashman JA, De Marzo AM, Joshu CE, <\/sup>Platz EA, Meeker AK. A high-throughput approach measures cell type-specific telomere lengths in fixed archival tissues from patient cohorts for research on prognosis.<\/strong> medRxiv<\/em><\/span> 2022 https:\/\/doi. org\/10.1101\/2022.01.20.22269597.<\/a><\/span><\/p>\n

2021<\/em><\/strong><\/h2>\n

Shrestha E, Coulter JB, Guzman W, Ozbek B, Hess MM, Mummert L, Ernst SE, Maynard JP, Meeker AK, Heaphy CM, Haffner MC, De Marzo AM, Sfanos KS. Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer.<\/strong> Proceedings of the National Academy of Science (PNAS) USA <\/em><\/span>2021;118:e2018976118.<\/a> <\/span>(Comment in Journal of Urology)<\/strong><\/em><\/span><\/a><\/span><\/p>\n

Heaphy CM, VandenBussche CJ. Prognostic biomarkers in pancreatic neuroendocrine tumors.<\/strong> Cancer Cytopathology<\/em> <\/span>2021;129:841-3.<\/a> <\/span>(Molecular Minute)<\/strong><\/span><\/a><\/em><\/span><\/p>\n

Brosnan-Cashman JA, Davis CM, Diplas BH, Meeker AK, Rodriguez FJ, Heaphy CM. SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma.<\/strong> Modern Pathology<\/em><\/span> 2021; 34:1810-9.<\/a><\/span><\/p>\n

Kang HJ, Oh JH, Kim YW, Kim W, An J, Sung CO, Kim J, Shim JH, Hwang S, Yu E,\u00a0<\/span>Heaphy CM, Hong SM. <\/span>Clinicopathological and molecular characterization of chromophobe hepatocellular carcinoma.<\/strong> Liver International<\/em><\/span> 2021;41:2499-510.<\/a><\/span><\/p>\n

Sullivan HH, Maynard JP, Heaphy CM, Lu J, De Marzo AM, Lotan TL, Joshu CE, Sfanos KS. Differential mast cell phenotypes in benign versus cancer tissues and prostate cancer oncologic outcomes<\/strong>. Journal of Pathology <\/em><\/span>2021;253:415-26.<\/a><\/span><\/p>\n

Joshu CE, <\/sup>Heaphy CM, Barber JR, Lu J, Zarinshenas R, Davis C, Han M, Lotan TL, <\/sup>Sfanos KS, De Marzo AM, Meeker AK, Platz EA. Obesity is associated with shorter telomere length in prostate stromal cells in men with aggressive prostate cancer.<\/strong> Cancer Prevention Research<\/em><\/span> 2021;14:463-70.<\/a><\/span><\/p>\n

Meeker AK, Heaphy CM, Davis CM, Roy S, Platz EA. Photochemical pre-bleaching of formalin-fixed archival prostate tissues significantly reduces autofluorescence to facilitate multiplex immunofluorescence staining<\/strong>. bioRxiv<\/em><\/span> 2021;https:\/\/doi.org\/10.1101\/2021.11.09.467916.<\/a><\/span><\/p>\n

2020<\/em><\/strong><\/h2>\n

Pea A, Yu J, Marchionni L, Noe M, Luchini C, Pulvirenti A, de Wilde RF, Brosens LA, Rezaee N, Javed A, Gobbo <\/sup>S, Regi P, Salvia R, Bassi C, He J, Weiss MJ, Cameron JL, Offerhaus GJA, Hruban RH, Lawlor RT, Scarpa A, Heaphy CM, Wood LD, Wolfgang CL. Genetic analysis of small well-differentiated pancreatic neuroendocrine tumors identifies subgroups with differing risks of liver metastases.<\/strong> Annals of Surgery<\/em><\/span> 2020;271:566-73.<\/a> <\/span>(Editorial in Hepatobiliary Surgery and Nutrition)<\/span><\/strong><\/a><\/em><\/p>\n

Esopi D, Graham MK, Brosnan-Cashman JA, Meyers J, Vaghasia A, Gupta A, Kumar B, Haffner MC, Heaphy CM, De Marzo AM, Meeker AK, Nelson WG, Wheelan SJ, Yegnasubramanian S. Pervasive promoter hypermethylation of silenced TERT alleles in human cancers.<\/strong> Cellular Oncology<\/em> <\/span>2020;43:847-61.<\/a><\/span><\/p>\n

Heaphy CM, Haffner MC, Graham MK, Lim D, Davis C, Corey E, Epstein JI, Eisenberger MA, Wang H, De Marzo AM, Meeker AK, Lotan TL. Telomere lengths differ significantly between small cell neuroendocrine prostate carcinoma and adenocarcinoma of the prostate.<\/strong> Human Pathology<\/em><\/span> 2020;101:70-9.<\/a><\/span><\/p>\n

Heaphy CM, Bi WL, Coy S, Davis C, Gallia GL, Santagata S, Rodriguez FJ. Telomere\u00a0length alterations and ATRX\/DAXX loss in pituitary adenomas.<\/strong> Modern Pathology<\/em><\/span> 2020;33:1475-81.<\/a><\/span><\/p>\n

pieterman CRC, Sadowski SM, Maxwell JE, Katz MHG, Lines KE, Heaphy CM, Tirosh A, Blau JE, Perrier ND, Lewis MA, Metzcar JP, Halperin DM, Thakker RV, Valk GD. MEN1-related pancreatic NETs: Identification of unmet clinical needs and future directives.<\/strong> Endocrine-Related Cancer<\/em><\/span> 2020;27:9-25.<\/a> <\/span>(World MEN 2019 Pancreatic NET Working Group)<\/strong><\/span><\/a><\/em><\/p>\n

Hackeng WM, Schelhaas W, Morsink FHM, Heidsma CM, van Eeden S, Valk GD, Vriens MR, Heaphy CM, Nieveen van Dijkum EJM, Offerhaus GJA, Dreijerink KMA, Brosens LAA. Alternative Lengthening of Telomeres and differential expression of endocrine transcription factors distinguish metastatic and non-metastatic insulinomas.<\/strong> Endocrine Pathology<\/em><\/span> 2020:31:108-18.<\/a><\/span><\/p>\n

Kim JK, Brosnan-Cashman JA, K<\/span>im J, An S, Lee KB, Kim H,<\/span> Park DY, <\/span>Jang KT, Oh YH, Hruban RH, Heaphy CM, Hong SM. Pancreatic acinar cell carcinomas and mixed acinar-neuroendocrine carcinomas are more clinically aggressive than grade 1 pancreatic neuroendocrine tumor.<\/strong> Pathology<\/em> <\/span>2020;52:336-47.<\/a><\/span><\/p>\n

Heaphy CM, Joshu CE, Barber JR, Davis C, Zarinshenas R, De Marzo AM, Lotan TL, Sfanos KS, Meeker AK,\u00a0Platz EA. Racial difference in prostate cancer cell telomere lengths in men with higher-grade prostate cancer: a clue to the racial disparity in prostate cancer outcomes.<\/strong> Cancer Epidemiology, Biomarkers & Prevention<\/em><\/span> 2020;29:676-80.<\/a><\/span><\/p>\n

Sullivan HH, Heaphy CM, Kulac I, Cuka NS, Lu J, Barber JR, De Marzo AM, Lotan TL, Joshu CE, Sfanos KS. High extra-tumoral mast cell counts are associated with a higher risk of adverse prostate cancer outcomes.<\/strong> Cancer Epidemiology, Biomarkers & Prevention<\/em> <\/span>2020;29:668-75.<\/a><\/span><\/p>\n

Felsenstein M, Trujillo MA, Huang B, Nanda N, Jiang Z, Jeong YJ, Pfl\u00fcger M, Goggins MG, Hruban RH, Thompson ED, Heaphy CM, Roberts NJ, Wood LD. Generation and characterization of a cell line from an intraductal tubulopapillary neoplasm of the pancreas.<\/strong> Laboratory Investigation<\/em><\/span> 2020;100:1003-13.<\/a><\/span><\/p>\n

Hackeng WM, Morsink FH, Moons LMG, Heaphy CM, Offerhaus GJA, Dreijerink KMA, Brosens LAA. Assessment of ARX expression, a novel biomarker for metastatic risk in pancreatic neuroendocrine tumors, in endoscopic ultrasound fine needle aspiration.<\/strong> Diagnostic Cytopathology<\/em><\/span> 2020;48:308-15.<\/a><\/span><\/p>\n

2019<\/em><\/strong><\/h2>\n

Cejas P., Drier Y., Dreijerink K.M.A., Brosens L.A.A., Deshpande V., Epstein C.B., Conemans E.B., Morsink F.H.M., Graham M.K., Valk G.D., Vriens M.R., Fernandez-del Castillo C., Ferrone C., Adar T., Bowden M., Whitton H., Da Silva A., Font-Tello A., Long H.W., Gaskell E., Shoresh N., Heaphy C.M., Sicinska E., Kulke M.H., Chung D.C., Bernstein B.E., Shivdasani R.A. Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumours.<\/strong> Nature Medicine<\/em><\/span> 2019;25:1264-9.<\/a> <\/span>(Press Release)<\/strong> <\/em><\/span><\/a>(Reviewed by Endocrine Surgery)<\/strong><\/em><\/span><\/a><\/p>\n

Tomasetti C., Poling J., Roberts N.J., London Jr N.R., Pittman M.E., Haffner M.C., Rizzo A., Baras A., Karim B., Kim A., Heaphy C.M., Meeker A.K., Hruban R.H., Iacobuzio-Donahue C.A., Vogelstein B. Stem cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence.<\/strong> Proceedings of the National Academy of Science (PNAS) USA<\/em><\/span> 2019;116:20482-8.<\/a> <\/span>(Press Release)<\/strong><\/em><\/span><\/a><\/p>\n

Graham M.K., Kim J., Da J., Brosnan-Cashman J.A., Rizzo A., Baena Del Valle J.A., Chia L., Rubenstein M., Davis C., Zheng Q., Cope L., Considine M., Haffner M.C., De Marzo A.M., Meeker A.K.,\u00a0Heaphy C.M. Functional loss of ATRX<\/em> and TERC<\/em> activates Alternative Lengthening of Telomeres (ALT) in LAPC4 prostate cancer cells.<\/strong> Molecular Cancer Research<\/em><\/span> 2019;17:2480-91.<\/a><\/span><\/p>\n

Flynn R.L., Heaphy C.M. Surviving telomere attrition with the MiDAS touch.<\/strong> Trends in Genetics<\/em><\/span> 2019;35:783-5.<\/a> <\/span>(Invited Commentary on Min et al.)<\/em><\/span><\/strong><\/a><\/p>\n

Rodriguez F.J., Graham M.K., Brosnan-Cashman J.A., Barber J.R., Davis C., Vizcaino M.A., Palsgrove D.N., Giannini C., Pekmezci M., Dahiya S., Gokden M., No\u00eb M., Wood L.D., Pratilas C.A., Morris C., Belzberg A., Blakeley J., Heaphy C.M. Telomere alterations in neurofibromatosis type 1-associated solid tumors.<\/strong> Acta Neuropathologica Communications<\/em><\/span> 2019;7:139.<\/a>\u00a0<\/span>(Press Release)<\/a> (2019 Moore Award for Best Paper on Clinico-Pathological Correlation Presented at AANP Annual Meeting)<\/a><\/span><\/strong><\/em><\/span><\/p>\n

Zarif J.C., Baena-Del Valle J.A., Hicks J.L., Heaphy C.M., Vidal I., Luo J., Lotan T.L., Hooper J.E., Isaacs W.B., Pienta K.J., De Marzo A.M. Mannose Receptor positive macrophage infiltrate correlates with prostate cancer onset and metastatic castrate-resistant disease.<\/strong> European Urology Oncology<\/em><\/span> 2019;2:429-36.<\/a><\/span><\/p>\n

Mart\u00ednez H., Nagurney M., Wang Z.X., Eberhart C.G., Heaphy C.M., Curtis M.T., Rodriguez F.J. ATRX<\/em> mutations in pineal parenchymal tumors of intermediate differentiation.<\/strong> Journal of Neuropathology & Experimental Neurology<\/em> <\/span>2019;78:703-8.<\/a><\/span><\/p>\n

Asaka S., Davis C., Lin <\/sup>S.F., Wang T.L., Heaphy C.M., Shih I.M. Analysis of telomere lengths in p53 signatures and incidental serous tubal intraepithelial carcinomas without cancer.<\/strong> American Journal of Surgical Pathology<\/em><\/span> 2019;43:1083-91.<\/a><\/span><\/p>\n

Trabzonlu L., Kulac I., Zheng Q., Hicks J.L., Haffner M.C., Nelson W.G., Sfanos K.S., Ertunc O., Lotan T.L., Heaphy C.M., Meeker A.K., Yegnasubramanian S., De Marzo A.M. <\/span>Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities.<\/strong>\u00a0<\/span>Cold Spring Harbor Perspective in Medicine\u00a0<\/span><\/em><\/span>2019;<\/span><\/span>9:<\/span><\/span>a030403.<\/span><\/a> <\/span>(Invited Review)<\/strong><\/em><\/span><\/p>\n

Rodriguez F.J., Brosnan-Cashman J.A., Allen S.J., Vizcaino M.A., Giannini C., Camelo-Piragua S., Webb M., Matsushita M., Wadhwani N., Tabbarah A., Hamideh D., Jiang L., Chen L., Arvantis L., Alnajar H.H., Barber J.R., Rodriguez-Velasco A., Orr B., Heaphy C.M. Alternative Lengthening of Telomeres, ATRX loss and H3 p.K27M mutations in histologically defined anaplastic pilocytic astrocytoma.<\/strong> Brain Pathology<\/em><\/span> 2019;29:126-40.<\/a><\/span><\/p>\n

Bell W.R., Meeker A.K., Rizzo A., Rajpara S., Rosenthal I.M., Flores Bellver M., Aparicio Domingo S., Zhong X., Barber J.R., Joshu C.E., Canto-Soler M.V., Eberhart C.G., Heaphy C.M. A unique telomere DNA expansion phenotype in human retinal rod photoreceptors associated with aging and disease.<\/strong> Brain Pathology<\/em><\/span> 2019;29:45-52.<\/a> <\/span>(Journal Cover) <\/em><\/strong><\/a><\/span><\/p>\n

Marrone M.T., Joshu C.E., Peskoe S.B., De Marzo A.M., Heaphy C.M., Lupold S.E., Meeker A.K., Platz E.A. Adding the team into T1 translational research: a case study of multidisciplinary team science in the evaluation of biomarkers of prostate cancer risk and prognosis.<\/strong> Clinical Chemistry<\/em><\/span> 2019;65:189-98.<\/a><\/span><\/p>\n

Selected Publications (2011-2018)<\/em><\/strong><\/h2>\n

Brosnan-Cashman J.A., Yuan M., Graham M.K., Rizzo A.J., Myers K., Davis C., Zhang R., Esopi D.M., Raabe E.H., Eberhart C.G., Heaphy C.M., Meeker A.K. ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific manner.<\/strong> PLoS ONE<\/em><\/span> 2018;13:e0204159.<\/a><\/span><\/p>\n

Baena Del Valle J.A., Zheng Q., Esopi D.M., Rubenstein M., Hubbard G.K., Moncaliano M.C., Hruszkewycz A., Vaghasia A., Yegnasubramanian S.,\u00a0Wheelan S.J., Meeker A.K., Heaphy C.M., Graham M.K., De Marzo A.M. MYC drives overexpression of telomerase RNA (hTR<\/em>\/TERC<\/em>) in prostate cancer.<\/strong> Journal of Pathology<\/em> <\/span>2018;244:11-24.<\/a><\/span><\/p>\n

Brosnan-Cashman J.A., Graham M.K., Heaphy C.M. Genetic alterations associated with ALTered telomeres.<\/strong> Oncotarget<\/em> <\/span>2018;9:33739-40.<\/span><\/a> (Invited Commentary on Mason-Osann et al.)<\/strong><\/em><\/span><\/a><\/strong><\/em><\/p>\n

Palsgrove D., Brosnan-Cashman J.A., Giannini C., Raghunathan A., Jentoft M., Bettegowda C., Gokden M., Ho C.Y., Lin M.T., Heaphy C.M., Rodriguez F.J. <\/sup>Subependymal giant cell astrocytoma -like astrocytoma: a neoplasm with a distinct phenotype and frequent neurofibromatosis type 1-association.<\/strong> Modern Pathology<\/em><\/span> 2018;31:1787-1800.<\/a><\/span><\/p>\n

Kim J.Y., Brosnan-Cashman J.A., An S., Kim S.J., Song K.B., Kim M.S., Kim M.J., Hwang D.W., Meeker A.K., Yu E., Kim S.C., Hruban R.H., Heaphy C.M., Hong S.M. Alternative lengthening of telomeres in primary pancreatic neuroendocrine neoplasms is associated with aggressive clinical behavior and poor survival.<\/strong> Clinical Cancer Research<\/em><\/span> 2017;23:1598-606.<\/a><\/span><\/p>\n

VandenBussche <\/sup>J., Allison <\/sup>D.B., Graham <\/sup>M.K., Charu <\/sup>V., Lennon <\/sup>A.M., Wolfgang <\/sup>C.L., Hruban <\/sup>R.H., Heaphy C.M. Alternative lengthening of telomeres and ATRX\/DAXX loss can reliably be detected in fine needle aspirates of pancreatic neuroendocrine tumors.<\/strong> Cancer Cytopathology<\/em><\/span> 2017;125:544-51.<\/a><\/span><\/p>\n

Rodriguez F.J., Vizcaino M.A., Blakeley J., Heaphy C.M. Frequent Alternative Lengthening of Telomeres and ATRX loss in adult NF1-associated diffuse and high grade astrocytomas.<\/strong> Acta Neuropathologica<\/em> <\/span>2016;132:761-3.<\/a><\/span><\/p>\n

Heaphy C.M., Gaonkar G., Peskoe S.B., Joshu C.E., De Marzo A.M., Lucia M.S., Goodman P.J., Lippman S.M., Thompson I.M., Platz E.A., Meeker A.K. Prostate stromal cell telomere shortening is associated with risk of prostate cancer in the placebo arm of the Prostate Cancer Prevention Trial.<\/strong> The Prostate<\/em><\/span> 2015;75:1160-6.<\/a><\/span><\/p>\n

Meeker AK, Heaphy CM. Gastroenteropancreatic endocrine tumors.<\/strong> Molecular and Cellular Endocrinology<\/span><\/em> 2014;386:101-20.<\/a> <\/span>(Invited Review)<\/span><\/strong><\/em><\/p>\n

Hurwitz LM, Heaphy CM, Joshu CE, Isaacs WB, Konishi Y, De Marzo AM, Isaacs SD, Wiley KE, Platz EZ, Meeker AK. Telomere length as a risk factor for hereditary prostate cancer.<\/strong> The Prostate<\/em> <\/span>2014;74:359-64.<\/a><\/span> (Highlighted in Journal of Urology)<\/strong><\/em><\/span><\/a><\/p>\n

Dogeas E, Karagkounis G, Heaphy CM, Hirose K, Pawlik TM, Wolfgang CL, Meeker AK, Hruban RH, Cameron JL, Choti MA. Alternative lengthening of telomeres predicts site of origin in neuroendocrine tumor liver metastases.<\/strong> Journal of the American College of Surgeons<\/em><\/span> 2014;218:628-35.<\/a> <\/span>(Accompanying Discussion)<\/span><\/strong><\/a><\/em><\/p>\n

Haffner M.C., Mosbruger T., Esopi D.M., Fedor H., Heaphy C.M., Walker D.A., Adejola N., Gurel M., Hicks J., Meeker A.K., Halushka M.K., Simons J.W., Isaacs W.B., De Marzo A.M., Nelson W.G., Yegnasubramanian S. Tracking the clonal origin of lethal prostate cancer.<\/strong> Journal of Clinical Investigation<\/em><\/span> 2013;123:4918-22.<\/a><\/span> (Accompanying Editorial)<\/strong><\/em><\/a> (Highlighted in European Urology)<\/strong><\/em><\/a> (Highlighted in Nature Reviews Clinical Oncology)<\/strong><\/em><\/a> (Highlighted in Journal of Clinical Investigation)<\/a> (Editorial Comment in Journal of Urology)<\/a><\/span><\/strong><\/em><\/span><\/p>\n

Heaphy C.M., Yoon G.S., Peskoe S.B., Joshu C.E., Lee T.K., Giovannucci E., Mucci L.A., Kenfield S.A., Stampfer M.J., Hicks J.L., De Marzo A.M., Platz E.A., Meeker A.K. Prostate cancer cell telomere length variability and stromal cell telomere length as prognostic markers for metastasis and death.<\/strong> Cancer Discovery<\/em><\/span> 2013;3:1130-41.<\/a> <\/span>(Press Release) <\/span><\/strong><\/em><\/a>(Accompanying Editorial)<\/strong><\/em><\/a> (Highlighted by The ASCO Post)<\/em><\/strong><\/a><\/span><\/p>\n

Heaphy C.M., Schreck K.C., Raabe E., Mao X., Chu Q., An P., Poh W., Jiao Y., Rodriguez F.J., Odia Y., Meeker A.K., Eberhart C.G. A glioblastoma neurosphere line with alternative lengthening of telomeres.<\/strong> Acta Neuropathologica<\/em> <\/span>2013;126:607-8.<\/a><\/span><\/p>\n

Jiao Y., Killela P.J.,\u00a0Reitman Z.J.,\u00a0Rasheed B.A.,\u00a0Heaphy C.M., de Wilde R.F.,\u00a0Rodriguez F.J., Rosemberg S,\u00a0Obashinjo S.M.,\u00a0Nagahashi Marie S.K.,\u00a0Bettegowda C.,\u00a0Agrawal N.,\u00a0Lipp E.,\u00a0Pirozzi C., Lopez G.,\u00a0He Y.,\u00a0Friedman H.,\u00a0Friedman A.H.,\u00a0Riggins G.J.,\u00a0Holdhoff M.,\u00a0Burger P.,\u00a0McLendon R.,\u00a0Bigner D.D.,\u00a0Vogelstein B.,\u00a0Meeker A.K., Kinzler K.W., Papadopoulos N.,\u00a0Diaz Jr. L.A., Yan H. Frequent ATRX, CIC, and FUBP1 mutations refine the classification of malignant gliomas.<\/strong> Oncotarget<\/em><\/span> 2012;3:709-22.<\/a><\/span><\/p>\n

Heaphy CM, Meeker AK. <\/sup>The potential utility of telomere-related markers for cancer diagnosis.<\/strong> Journal of Cellular and Molecular Medicine<\/em><\/span> 2011;15:1227-38.<\/a><\/span> (Review)<\/strong><\/span><\/em><\/p>\n

Konishi H., Mohseni M., Tamaki A., Garay J.P., Croessmann S., Karnan S., Ota A., Wong H.Y., Konishi Y., Karakas B., Tahir K., Abukhdeir A.M., Gustin J.P., Cidado J., Wang G.M., Cosgrove D., Cochran R., Jelovac D., Higgins M.J., Arena S., Hawkins L., Lauring J., Gross A.L., Heaphy C.M., Hosokawa Y., Gabrielson E., Meeker A.K., Visvanathan K., Argani P., Bachman K.E., Park B.H. Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.<\/strong> Proceedings of the National Academy of Science (PNAS) USA<\/em><\/span> 2011;108:17773-8.<\/a> <\/span>(Highlighted in Women’s Health)<\/strong><\/em><\/span><\/a><\/p>\n

Heaphy C.M., Subhawong A.P., Hong S.M., Goggins M.G., Montgomery E.A., Gabrielson E., Netto G.J., Epstein J.I., Lotan T.L., Westra W.H., Shih I.M., Iacobuzio-Donahue C.A., Maitra A., Li Q.K., Eberhart C.G., Taube J.M., Rakheja D., Kurman R.J., Wu T., Roden R.B., Argani P., De Marzo A.M., Terracciano L., Torbenson M., Meeker A.K. Prevalence of the Alternative Lengthening of Telomeres (ALT) telomere maintenance mechanism in human cancer subtypes.<\/strong> The American Journal of Pathology<\/em> <\/span>2011;179:1608-15.<\/a> <\/span>(Press Release)<\/strong><\/em><\/a> (Winner of the Stowell-Orbison Award at the 2011 USCAP Annual Meeting)<\/a><\/strong><\/span><\/p>\n

Wang Y., Meeker A.K., Kowalski J., Tsai H.L., Somervell H., Heaphy C.M., Sangenario L.E., Prasad N., Westra W.H., Zeiger M.A., Umbricht C.B. Telomere length is related to alternative splice patterns of telomerase in thyroid tumors.<\/strong> The American Journal of Pathology<\/em><\/span> 2011;179:1415-24.<\/a><\/span><\/span><\/p>\n

Heaphy C.M., de Wilde R.F., Jiao Y., Klein A.P., Edil B.H., Shi C., Bettegowda C., Rodriguez F.J., Eberhart C.G., Hebbar S., Offerhaus G.J., McLendon R., Rasheed B.A., He Y., Yan H., Bigner D.D., Oba-Shinjo S.M., Nagahashi Marie S.K., Riggins G.J., Kinzler K.W., Vogelstein B., Hruban R.H., Maitra A., Papadopoulos N., Meeker A.K. Altered telomeres in tumors with ATRX<\/em> and DAXX.<\/em><\/strong>\u00a0Science<\/span><\/em> 2011;333:425.<\/a><\/span> (Press Release)<\/strong><\/span><\/em><\/a> (Highlighted in JAMA)<\/strong><\/em><\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Current preprints Song H, Xu J, Velazquez-Arcelay K, Demirci A, Raizenne BL, Hsu SC, Choi J, Pham JH, Chen Y, Weinstein HNW, Salzman I, Tsui M, Akutagawa J, Adingo W, Goldschmidt E, Carroll PR, Hong JC, Heaphy CM, Cooperberg MR, Greenland N, Campbell JD, Huang FW. A single-cell and spatial atlas of prostate cancer reveals […]<\/p>\n","protected":false},"author":17343,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/pages\/32"}],"collection":[{"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/users\/17343"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/comments?post=32"}],"version-history":[{"count":50,"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/pages\/32\/revisions"}],"predecessor-version":[{"id":1211,"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/pages\/32\/revisions\/1211"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/heaphylab\/wp-json\/wp\/v2\/media?parent=32"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}