Tag: protein stability

New paper: Structural Basis for the Stabilization of Amyloidogenic Immunoglobulin Light Chains by Hydantoins

in Publication, Research, Science

How does a curved molecule fit into a flat binding pocket? Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins. Nicholas L. Yan, Diogo Santos-Martins, Enrico Rennella, Brittany B. Sanchez, Jason S. Chen, Lewis E. Kay, Ian A. Wilson, Gareth J. Morgan, Stefano Forli, Jeffery W. Kelly Bioorganic & Medicinal Chemistry Letters […]

Tags: AL amyloidosis, amyloid, new, paper, protein stability

A high-throughput screen for protein stability

in Research, Science

We have developed a new method for measuring protein stability that can be used in high throughput screens. We hope that this will be a useful alternative to existing methods for researchers looking for molecules that bind to and stabilize proteins. Details are in our new paper. Proteins are dynamic, flexible polymers that can form […]

Tags: amyloid, Methods, paper, PCFP, protein stability, research