Ganem Lab Publications

Selected Publications:

  • Quinton R.J., DiDomizio A., Vittoria M.A., Kotýnková K., Ticas C.J., Patel S., Koga Y., Vakhshoorzadeh J., Hermance N., Kuroda T.S., Parulekar N., Taylor A.M., Manning, A.L., Campbell J.D., Ganem N.J. Nature. Whole genome doubling confers unique genetic dependencies on tumor cells. 2021. 590(7846):492-497.
  • Gan W., Dai, X Xie J., Yin S., Zhu J., Wang C., Liu Y., Guo J., Wang M., Liu J., Hua J., Quinton RJ, Ganem N.J., Liu P., Asara J.M., Pandolfi P.P., Yang Y., He Z., Gao G., and Wei, W. LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control. Nat Cell Biol. 2020 Feb;22(2):246-256.
  • Lim S., Hermance N., Mudianto T., Mustaly H., Mauricio I.P., Vittoria M.A., Quinton R.J., Howell B.W., Cornils H., Manning A.L., and Ganem N.J. Identifying STK25 as a novel activator of LATS kinases. 2019. Nat Comm. 4;10(1):1547.
  • Vittoria M.A., Shenk E.M., O’Rourke K.P., Bolgioni A.F., Lim S., Kacprzak V., Quinton R.J., and Ganem N.J. 2018.A genome-wide miRNA screen identifies regulators of tetraploid cell proliferation. Mol Biol Cell. 29(13):1682-1692.
  • Flynn RL, Cox KE, Jeitany M, Wakimoto H, Bryll AR, Ganem NJ, Bersani F, Pineda JR, Suvà ML, Benes C, Haber DA, Boussin FD, Zou L. 2015. Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors. Science. 347:273-277
  • Ganem NJ*, Cornils H, ChiuSY, O’RourkeKP, Yimlamai D, Thery M, Camargo FD, and Pellman D. 2014. Cytokinesis failure triggers Hippo pathway activation. Cell. 158(4):833-848. *Co-corresponding author.
  • Crasta K, Ganem NJ, Dagher R, Lantermann AB, Ivanova EV, Pan Y, Nezi L, Protopopov A, Chowdhury D, and Pellman D. 2012. Errors in mitosis cause DNA breaks and chromosome pulverization. Nature. 482(7383):53-58. PMID: 22258507.
  • Rhodes J, Amsterdam A, Sanda T, Moreau LA, McKenna K, Heinrichs S, Ganem NJ, Ho KW, Neuberg DS, Johnston A, Ahn Y, Kutok JL, Hromas R, Wray J, Lee C, Murphy C, Radtke I, Downing JR, Fleming MD, MacConaill LE, Amatruda JF, Gutierrez A, Galinsky I, Stone RM, Ross EA, Pellman DS, Kanki JP, and Look AT. 2009. Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression. Mol Cell Biol. 29:5911-5922. PMID: 19704007.


          • Ganem NJ, Godinho SA, and Pellman D.  2009.  A mechanism linking extra centrosomes to chromosome instability.  Nature.  460:278-282. PMID: 19506557.


          • Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M, and Pellman D. 2008.  Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.  Genes Dev.  22(16):2189-2203. PMID: 18662975.


          • Ganem NJ, and Pellman D. 2007. Limiting the proliferation of polyploid cells. Cell. 131:437-440. PMID: 17981108.
          • Ganem NJ, Storchova Z, and Pellman D. 2007. Tetraploidy, aneuploidy, and cancer. Curr Opin Genet Dev. 17:157-162. PMID: 17324569.

          Vol 17 Iss 2 Tetraploid cells

          • Manning AL*, Ganem NJ*, Bakhoum SF, Wagenbach M, Wordeman L, and Compton DA. 2007. The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.  Mol. Biol. Cell. 18(8):2970-2979. *Co-first authors. PMID: 17538014.


          • Ganem NJ, and Compton DA. 2006. Functional roles of poleward microtubule flux during mitosis. Cell Cycle.  5:481-485. PMID: 16552178.


          • Couch RD, Ganem NJ, Zhou M, Popov V, Honda T, Veenstra T, Sporn MB, and Anderson AC.  2005. 2-cyano-3,12-dioxooleana-1,9(11)-diene-28-oic acid (CDDO) disrupts microtubule polymerization: A possible mechanism contributing to apoptosis. J. Mol. Pharm. 69:1158-1165. PMID: 16407469.


          • Ganem NJ, Upton K, and Compton DA.  2005. Efficient mitosis in human cells lacking poleward microtubule flux. Curr. Biol. 15(20): 1827-1832. PMID: 16243029.
          • Ganem NJ, and Compton DA.  2004. The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J. Cell. Biol. 166(4): 473-478. PMID: 15302853.