{"id":234,"date":"2019-10-31T15:56:57","date_gmt":"2019-10-31T19:56:57","guid":{"rendered":"https:\/\/sites.bu.edu\/ctmlab\/?page_id=234"},"modified":"2019-11-06T16:52:42","modified_gmt":"2019-11-06T21:52:42","slug":"analytical-modeling-of-alveolar-and-lung-tissue-behavior","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/ctmlab\/projects\/analytical-modeling-of-alveolar-and-lung-tissue-behavior\/","title":{"rendered":"Analytical Modeling of Alveolar and Lung Tissue Mechanics"},"content":{"rendered":"<p><img loading=\"lazy\" src=\"\/ctmlab\/files\/2019\/10\/Analytical-Models-636x360.png\" alt=\"\" width=\"636\" height=\"360\" class=\"alignnone size-medium wp-image-237\" srcset=\"https:\/\/sites.bu.edu\/ctmlab\/files\/2019\/10\/Analytical-Models-636x360.png 636w, https:\/\/sites.bu.edu\/ctmlab\/files\/2019\/10\/Analytical-Models-768x434.png 768w, https:\/\/sites.bu.edu\/ctmlab\/files\/2019\/10\/Analytical-Models-1024x579.png 1024w, https:\/\/sites.bu.edu\/ctmlab\/files\/2019\/10\/Analytical-Models.png 1282w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><\/p>\n<p><span>Our lab is interested in understanding how macroscopic\u00a0behavior results from microscopic properties and how these are intertwined to serve a particular structure-function relationship. To this end, we develop analytical multi-scale mathematical models to relate macroscopic measurements to microscopic properties. As an example, such models relate\u00a0(1) stress-strain curves in uniaxially stretched lung tissue strips to alveolar wall and fiber properties and (2) macroscopic pressure-volume curves to microscopic fiber properties (i.e. stiffness and waviness). Through these models we can estimate the properties of the micro-constituents such as fiber and alveolar wall stiffness as well as shed light on how their organization serves different roles. For instance, the alveolar model has predicted that across species the thickness-to-radius ratio of alveoli remains constant to satisfy alveolar inflation stability and preliminary literature results support this finding.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our lab is interested in understanding how macroscopic\u00a0behavior results from microscopic properties and how these are intertwined to serve a particular structure-function relationship. To this end, we develop analytical multi-scale mathematical models to relate macroscopic measurements to microscopic properties. As an example, such models relate\u00a0(1) stress-strain curves in uniaxially stretched lung tissue strips to alveolar [&hellip;]<\/p>\n","protected":false},"author":16079,"featured_media":0,"parent":25,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/pages\/234"}],"collection":[{"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/users\/16079"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/comments?post=234"}],"version-history":[{"count":9,"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/pages\/234\/revisions"}],"predecessor-version":[{"id":261,"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/pages\/234\/revisions\/261"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/pages\/25"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/media?parent=234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}