{"id":111,"date":"2019-03-16T10:41:49","date_gmt":"2019-03-16T14:41:49","guid":{"rendered":"https:\/\/sites.bu.edu\/ctmlab\/?page_id=111"},"modified":"2019-09-06T11:54:37","modified_gmt":"2019-09-06T15:54:37","slug":"multi-scale-modeling-of-fibrosis-emphysema","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/ctmlab\/projects\/multi-scale-modeling-of-fibrosis-emphysema\/","title":{"rendered":"Multi-Scale Modeling of Fibrosis &#038; Emphysema"},"content":{"rendered":"<p>The purpose of this project is to discover emergent phenomena resulting from the complex interplay of cells and their extracellular matrix in the dynamic mechanical environment of the lungs.\u00a0 These mechanical interactions occur across size scales ranging from individual collagen and elastin fibers, to alveolar septa comprising\u00a0a network of fibers, to regions of lung parenchymal tissue comprising hundreds of alveoli.\u00a0 Predictions from these models may explain characteristic\u00a0structural alterations in progressive lung diseases and reveal potential targets for early diagnosis and therapeutic intervention.<\/p>\n<p><img loading=\"lazy\" src=\"\/ctmlab\/files\/2019\/09\/collagen_SEM.png\" alt=\"\" width=\"1417\" height=\"466\" class=\"wp-image-183 size-full\" srcset=\"https:\/\/sites.bu.edu\/ctmlab\/files\/2019\/09\/collagen_SEM.png 1417w, https:\/\/sites.bu.edu\/ctmlab\/files\/2019\/09\/collagen_SEM-636x209.png 636w, https:\/\/sites.bu.edu\/ctmlab\/files\/2019\/09\/collagen_SEM-768x253.png 768w, https:\/\/sites.bu.edu\/ctmlab\/files\/2019\/09\/collagen_SEM-1024x337.png 1024w\" sizes=\"(max-width: 1417px) 100vw, 1417px\" \/><br style=\"clear: both;\" \/>Scanning electron microscope images of single fibers and fibrous networks obtained from bovine lung tissue.<\/p>\n<div style=\"width: 1000px;\" class=\"wp-video\"><!--[if lt IE 9]><script>document.createElement('video');<\/script><![endif]-->\n<video class=\"wp-video-shortcode\" id=\"video-111-1\" width=\"1000\" height=\"460\" poster=\"\/ctmlab\/files\/2019\/09\/spring_network_breaking_still.png\" loop=\"1\" autoplay=\"1\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/mp4\" src=\"\/ctmlab\/files\/2019\/09\/spring_network_breaking.mp4?_=1\" \/><a href=\"\/ctmlab\/files\/2019\/09\/spring_network_breaking.mp4\">\/ctmlab\/files\/2019\/09\/spring_network_breaking.mp4<\/a><\/video><\/div>\n<p>Three-dimensional spring network model of lung parenchyma demonstrating the formation of emphysematous structure via force-induced rupture.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The purpose of this project is to discover emergent phenomena resulting from the complex interplay of cells and their extracellular matrix in the dynamic mechanical environment of the lungs.\u00a0 These mechanical interactions occur across size scales ranging from individual collagen and elastin fibers, to alveolar septa comprising\u00a0a network of fibers, to regions of lung parenchymal [&hellip;]<\/p>\n","protected":false},"author":16077,"featured_media":0,"parent":25,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/pages\/111"}],"collection":[{"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/users\/16077"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/comments?post=111"}],"version-history":[{"count":11,"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/pages\/111\/revisions"}],"predecessor-version":[{"id":184,"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/pages\/111\/revisions\/184"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/pages\/25"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/ctmlab\/wp-json\/wp\/v2\/media?parent=111"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}