Multi-Scale Modeling of Fibrosis & Emphysema

The purpose of this project is to discover emergent phenomena resulting from the complex interplay of cells and their extracellular matrix in the dynamic mechanical environment of the lungs.  These mechanical interactions occur across size scales ranging from individual collagen and elastin fibers, to alveolar septa comprising a network of fibers, to regions of lung parenchymal tissue comprising hundreds of alveoli.  Predictions from these models may explain characteristic structural alterations in progressive lung diseases and reveal potential targets for early diagnosis and therapeutic intervention.

Scanning electron microscope images of single fibers and fibrous networks obtained from bovine lung tissue.

Three-dimensional spring network model of lung parenchyma demonstrating the formation of emphysematous structure via force-induced rupture.