Projects

Our lab’s technical expertise lies at the intersection of biology, mechanics, and physics. Our experimental projects span a wide range of size scales including nanoparticle design for targeted drug delivery, tensile testing of extracellular matrix fibers, quantifying biological response to stretch in cells and tissue strips, and measuring total pulmonary mechanical function in ventilated patients. We love mathematical equations, and we strive to develop analytical and numerical models that reveal new insights or predictions about complex biomechanical behaviors. Please read more about our active research projects:

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Multi-Scale Modeling of Fibrosis & Emphysema
Constructing an open-source framework for investigating disease initiation, progression, and treatment strategies, based on the emergent behaviors of complex interactions between cells and their environments.
Bronchial Particle Deposition
Identifying key determinants of targeted drug deposition during low-flow conditions.
Biomechanical Determinants of Emphysema Progression
Using computational models to predict force-based tissue destruction, and assess the efficacy of interventional lung volume reduction.
Analytical Modeling of Alveolar and Lung Tissue Mechanics
Uniaxial lung tissue model (left) and alveolar model (right)
Assessing Respiratory Mechanics in Ventilated Patients
Novel strategy to assess respiratory mechanics