{"id":34,"date":"2016-11-17T10:51:21","date_gmt":"2016-11-17T15:51:21","guid":{"rendered":"https:\/\/sites.bu.edu\/chitalialab\/?page_id=34"},"modified":"2021-01-05T17:04:22","modified_gmt":"2021-01-05T22:04:22","slug":"angiogenesis","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/chitalialab\/research\/angiogenesis\/","title":{"rendered":"Vascular Diseases in Cancer"},"content":{"rendered":"<p>Cancer progresses through several steps characterized by a conversion of normal tissue states to anaplasia and neoplasia. While the tumor continues to grow in a conducive environment, it draws leash of blood vessels along with it. Angiogenesis, a process of generation of novel blood vessels is fundamental during the development and in various diseases such as cancer. Wnt signaling, a highly conserved oncogenic pathway, is critical in angiogenesis. Beta-catenin is the prime mediator of Wnt activation. Focusing on the ubiquitination and proteasomal degradation of beta-catenin, our previous work has described Jade-1, as an ubiquitin ligase of wild-type beta catenin. Our recent efforts have specifically focused on c-Cbl as an E3 ligase for the mutant beta-catenin and the transcriptionally active beta-catenin in the nucleus. These two species of beta-catenin, once considered resistant to degradation, are the key mediators of tumorigenesis and are effectively downregulated by c-Cbl. Thus, c-Cbl is a unique E3 ligase of tumorigenic beta catenin, which is involved in several cancers including colorectal cancer pathogenesis.\u00a0 Leveraging the cancer animal models and human cancer samples including machine-learning based quantitative histology techniques, our group investigates the colorectal cancer pathogenesis to gain a deeper understanding of the role of E3 ligases of beta-catenin E3 ligases in various cancers.<\/p>\n<p>&nbsp;<\/p>\n<div class=\"parallax-2 bottom-parallax\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Cancer progresses through several steps characterized by a conversion of normal tissue states to anaplasia and neoplasia. While the tumor continues to grow in a conducive environment, it draws leash of blood vessels along with it. Angiogenesis, a process of generation of novel blood vessels is fundamental during the development and in various diseases such [&hellip;]<\/p>\n","protected":false},"author":7251,"featured_media":0,"parent":461,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"page-templates\/no-sidebars.php","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/chitalialab\/wp-json\/wp\/v2\/pages\/34"}],"collection":[{"href":"https:\/\/sites.bu.edu\/chitalialab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/chitalialab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/chitalialab\/wp-json\/wp\/v2\/users\/7251"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/chitalialab\/wp-json\/wp\/v2\/comments?post=34"}],"version-history":[{"count":9,"href":"https:\/\/sites.bu.edu\/chitalialab\/wp-json\/wp\/v2\/pages\/34\/revisions"}],"predecessor-version":[{"id":1426,"href":"https:\/\/sites.bu.edu\/chitalialab\/wp-json\/wp\/v2\/pages\/34\/revisions\/1426"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/chitalialab\/wp-json\/wp\/v2\/pages\/461"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/chitalialab\/wp-json\/wp\/v2\/media?parent=34"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}