Marc Arthur Napoleon
IS, an uremic toxin and tryptophan metabolite retained by the kidney mediates its atherothrombotic toxicity in Chronic Kidney Disease (CKD) through the Aryl Hydrocarbon Receptor (AHR), and Tissue Factor pathway in the vessels walls. Among several analogs of IS inhibitors, we have been investigating the role of Indole 3 methanol (I3M), a plant metabolite found in cruciferous vegetables, in vitro and in vivo of mouse adenine CKD model. Our previous work showed that intraperitoneal administration of I3M injection inhibits thrombosis in the adenine induced CKD model. Now, we are destined to find out if cruciferous plants with high levels of I3M can inhibit uremic thrombosis using a customized chow with 50% Brussel sprouts.