{"id":1000,"date":"2019-12-29T14:31:45","date_gmt":"2019-12-29T19:31:45","guid":{"rendered":"https:\/\/sites.bu.edu\/cheng-group\/?page_id=1000"},"modified":"2024-12-20T17:12:10","modified_gmt":"2024-12-20T22:12:10","slug":"optoacoustic-neural-stimulation","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/cheng-group\/research\/optoacoustic-neural-stimulation\/","title":{"rendered":"Drug-Free Treatment"},"content":{"rendered":"<p><b>4.1 Optoacoustic brain stimulation at submillimeter to single-neuron precision<\/b><\/p>\n<p>Low-intensity ultrasound is an emerging modality for neuromodulation. Yet, transcranial neuromodulation using low-frequency piezo-based transducers offers poor spatial confinement of excitation volume, often bigger than a few millimeters in diameter. In addition, the bulky size limits their implementation in a wearable setting and prevents integration with other experimental modalities. Here, we report spatially confined optoacoustic neural stimulation through a novel miniaturized Fiber-Optoacoustic Converter (FOC). The FOC has a diameter of 600 \u03bcm and generates an omnidirectional ultrasound wave locally at the fiber tip through the optoacoustic effect. We show that the optoacoustic wave can directly activate individual cultured neurons and generate intracellular Ca2+ transients<i>.<\/i> The FOC activates neurons within a radius of 500 \u03bcm around the fiber tip, delivering superior spatial resolution over conventional piezo-based low-frequency transducers. Using FOC, we demonstrated direct and spatially confined neural stimulation of mouse brain and modulation of motor activity<i> in vivo. <\/i>[Nature Communications 2020]<\/p>\n<p><b><img loading=\"lazy\" src=\"\/cheng-group\/files\/2019\/12\/neural-stimulation.png\" alt=\"\" width=\"1519\" height=\"787\" class=\"aligncenter size-full wp-image-1008\" srcset=\"https:\/\/sites.bu.edu\/cheng-group\/files\/2019\/12\/neural-stimulation.png 1519w, https:\/\/sites.bu.edu\/cheng-group\/files\/2019\/12\/neural-stimulation-636x330.png 636w, https:\/\/sites.bu.edu\/cheng-group\/files\/2019\/12\/neural-stimulation-768x398.png 768w, https:\/\/sites.bu.edu\/cheng-group\/files\/2019\/12\/neural-stimulation-1024x531.png 1024w\" sizes=\"(max-width: 1519px) 100vw, 1519px\" \/><\/b><\/p>\n","protected":false},"excerpt":{"rendered":"<p>4.1 Optoacoustic brain stimulation at submillimeter to single-neuron precision Low-intensity ultrasound is an emerging modality for neuromodulation. Yet, transcranial neuromodulation using low-frequency piezo-based transducers offers poor spatial confinement of excitation volume, often bigger than a few millimeters in diameter. In addition, the bulky size limits their implementation in a wearable setting and prevents integration with [&hellip;]<\/p>\n","protected":false},"author":13793,"featured_media":0,"parent":27,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/cheng-group\/wp-json\/wp\/v2\/pages\/1000"}],"collection":[{"href":"https:\/\/sites.bu.edu\/cheng-group\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/cheng-group\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/cheng-group\/wp-json\/wp\/v2\/users\/13793"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/cheng-group\/wp-json\/wp\/v2\/comments?post=1000"}],"version-history":[{"count":4,"href":"https:\/\/sites.bu.edu\/cheng-group\/wp-json\/wp\/v2\/pages\/1000\/revisions"}],"predecessor-version":[{"id":2150,"href":"https:\/\/sites.bu.edu\/cheng-group\/wp-json\/wp\/v2\/pages\/1000\/revisions\/2150"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/cheng-group\/wp-json\/wp\/v2\/pages\/27"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/cheng-group\/wp-json\/wp\/v2\/media?parent=1000"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}