{"id":168,"date":"2021-10-15T17:56:03","date_gmt":"2021-10-15T21:56:03","guid":{"rendered":"https:\/\/sites.bu.edu\/buckdntresearch\/?page_id=168"},"modified":"2022-01-07T15:55:45","modified_gmt":"2022-01-07T20:55:45","slug":"study-ii","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/buckdntresearch\/our-research\/early-exposure\/study-ii\/","title":{"rendered":"Study II (2016)"},"content":{"rendered":"<p><span style=\"font-weight: 400;\">In 2016, our team recruited 650 children in Nicaragua. This study differed from the first study in that we selected three high-risk locations (Chichigalpa, La Paz Centro, Mina El Lim\u00f3n) and one reference location for comparison (Managua) and broadened the ages of children in the study (ages 7-17). In addition to measuring creatinine levels on all participants, we also have analyzed biomarkers of kidney injury (NGAL, IL-18, MCP-1, YKL-40 and KIM-1) among a subset of 210 children.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">We identified significant elevations in kidney injury biomarkers among youth with no occupational experiencing, suggesting that kidney injury was occurring prior to working life.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><span style=\"font-weight: 400;\"><strong>Publications:\u00a0<\/strong>Leibler JH, Ramirez-Rubio O, Vel\u00e1zquez JJA, Pilarte DL, Obeid W, Parikh CR, Gadupudi S, Scammell MK, Friedman DJ, Brooks DR. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32504218\/\" target=\"_blank\" rel=\"noopener noreferrer\">Biomarkers of kidney injury among children in a high-risk region for chronic kidney disease of uncertain etiology.<\/a> Pediatr Nephrol. 2021 Feb;36(2):387-396. doi: 10.1007\/s00467-020-04595-3. Epub 2020 Jun 5. PMID: 32504218.<\/span><\/p>\n<p><strong>An accompanying editorial was published alongside this paper:\u00a0<\/strong><span style=\"font-weight: 400;\">Abeyagunawardena AS, Shroff R. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32415327\/\" target=\"_blank\" rel=\"noopener noreferrer\">CKDu: the known unknowns.<\/a> Pediatr Nephrol. 2021 Feb;36(2):219-221. doi: 10.1007\/s00467-020-04596-2. Epub 2020 May 15. PMID: 32415327.<\/span><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In 2016, our team recruited 650 children in Nicaragua. This study differed from the first study in that we selected three high-risk locations (Chichigalpa, La Paz Centro, Mina El Lim\u00f3n) and one reference location for comparison (Managua) and broadened the ages of children in the study (ages 7-17). In addition to measuring creatinine levels on [&hellip;]<\/p>\n","protected":false},"author":19802,"featured_media":0,"parent":56,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/buckdntresearch\/wp-json\/wp\/v2\/pages\/168"}],"collection":[{"href":"https:\/\/sites.bu.edu\/buckdntresearch\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/buckdntresearch\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/buckdntresearch\/wp-json\/wp\/v2\/users\/19802"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/buckdntresearch\/wp-json\/wp\/v2\/comments?post=168"}],"version-history":[{"count":8,"href":"https:\/\/sites.bu.edu\/buckdntresearch\/wp-json\/wp\/v2\/pages\/168\/revisions"}],"predecessor-version":[{"id":734,"href":"https:\/\/sites.bu.edu\/buckdntresearch\/wp-json\/wp\/v2\/pages\/168\/revisions\/734"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/buckdntresearch\/wp-json\/wp\/v2\/pages\/56"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/buckdntresearch\/wp-json\/wp\/v2\/media?parent=168"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}