{"id":85,"date":"2021-10-08T16:30:28","date_gmt":"2021-10-08T20:30:28","guid":{"rendered":"https:\/\/sites.bu.edu\/buckdntresearch-es\/?page_id=85"},"modified":"2022-03-18T14:59:53","modified_gmt":"2022-03-18T18:59:53","slug":"biomarkers-of-kidney-function-and-injury-among-sugarcane-workers-in-nicaragua-2010-2016","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/buckdntresearch-es\/our-research\/adult-occupation\/biomarkers-of-kidney-function-and-injury-among-sugarcane-workers-in-nicaragua-2010-2016\/","title":{"rendered":"Biomarcadores de funci\u00f3n y lesi\u00f3n renal entre los trabajadores de la ca\u00f1a de az\u00facar en Nicaragua: 2010-2016"},"content":{"rendered":"

En <\/span>Centroam\u00e9rica<\/span> se ha <\/span>descrito<\/span> <\/span>una<\/span> <\/span>epidemia<\/span> de <\/span>enfermedad<\/span> renal <\/span>cr\u00f3nica<\/span> (ERC) de <\/span>etiolog\u00eda<\/span> <\/span>desconocida<\/span> entre <\/span>los<\/span> <\/span>trabajadores<\/span> <\/span>agr\u00edcolas<\/span> <\/span>j\u00f3venes<\/span> de <\/span>sexo<\/span> <\/span>masculino<\/span>. <\/span>Aunque<\/span> se <\/span>han<\/span> <\/span>formulado<\/span> <\/span>muchas<\/span> <\/span>hip\u00f3tesis<\/span> <\/span>sobre<\/span> <\/span>causas<\/span> <\/span>ocupacionales<\/span> y no <\/span>ocupacionales<\/span> (<\/span>por<\/span> <\/span>ejemplo<\/span>, <\/span>estr\u00e9s<\/span> <\/span>t\u00e9rmico<\/span>, <\/span>metales<\/span> <\/span>pesados<\/span>), <\/span>el<\/span> <\/span>agente<\/span> <\/span>etiol\u00f3gico<\/span> <\/span>sigue<\/span> <\/span>siendo<\/span> <\/span>desconocido<\/span>. Los <\/span>objetivos<\/span> de <\/span>este<\/span> <\/span>proyecto<\/span> <\/span>fueron<\/span>: (1) <\/span>evaluar<\/span> las <\/span>medidas<\/span> <\/span>repetidas<\/span> de <\/span>los<\/span> <\/span>biomarcadores<\/span> de <\/span>lesi\u00f3n<\/span> renal y ERC entre <\/span>los<\/span> <\/span>trabajadores<\/span> de la <\/span>ca\u00f1a<\/span> de <\/span>az\u00facar<\/span> <\/span>investigando<\/span> las <\/span>diferencias<\/span> <\/span>por<\/span> <\/span>tarea<\/span> <\/span>laboral<\/span>; (2) <\/span>determinar<\/span> <\/span>si<\/span> <\/span>hab\u00eda<\/span> <\/span>evidencia<\/span> de <\/span>lesi\u00f3n<\/span> renal y ERC entre <\/span>los<\/span> <\/span>mineros<\/span>, <\/span>trabajadores<\/span> de la <\/span>construcci\u00f3n<\/span> y <\/span>estibadores<\/span> que <\/span>nunca<\/span> <\/span>hab\u00edan<\/span> <\/span>trabajado<\/span> <\/span>en<\/span> la <\/span>industria<\/span> de la <\/span>ca\u00f1a<\/span> de <\/span>az\u00facar<\/span>; (3) <\/span>caracterizar<\/span> <\/span>los<\/span> <\/span>biomarcadores<\/span> de <\/span>exposici\u00f3n<\/span> a <\/span>metales<\/span> <\/span>pesados<\/span> <\/span>nefrot\u00f3xicos<\/span> (es <\/span>decir<\/span>, <\/span>cadmio<\/span>, <\/span>plomo<\/span>, <\/span>uranio<\/span>, <\/span>ars\u00e9nico<\/span>) y <\/span>examinar<\/span> la <\/span>asociaci\u00f3n<\/span> con <\/span>los<\/span> <\/span>biomarcadores<\/span> de <\/span>da\u00f1o<\/span> renal. Los <\/span>datos<\/span> <\/span>analizados<\/span> se <\/span>recogieron<\/span> <\/span>en<\/span> <\/span>proyectos<\/span> <\/span>anteriores<\/span> <\/span>realizados<\/span> <\/span>por<\/span> <\/span>el<\/span> <\/span>grupo<\/span> de <\/span>investigaci\u00f3n<\/span>. Los <\/span>resultados<\/span> se <\/span>encuentran<\/span> <\/span>en<\/span> <\/span>varias<\/span> <\/span>fases<\/span> de <\/span>publicaci\u00f3n<\/span> <\/span>en<\/span> <\/span>revistas<\/span> <\/span>revisadas<\/span> <\/span>por<\/span> pares (<\/span>ver<\/span> Publicaciones<\/a>).<\/span><\/span><\/span><\/p>\n

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Financiaci\u00f3n<\/span><\/span>:<\/strong>El <\/span>trabajo<\/span> de Rebecca Law <\/span>en<\/span> <\/span>este<\/span> <\/span>proyecto<\/span> <\/span>fue<\/span> <\/span>financiado<\/span> <\/span>por<\/span> <\/span>el<\/span> <\/span>programa<\/span> de <\/span>becas<\/span> Ciencia para <\/span>Lograr<\/span> <\/span>Resultados<\/span> (STAR <\/span>por<\/span> sus <\/span>siglas<\/span> <\/span>ingl\u00e9s<\/span>) de la Agencia de <\/span>Protecci\u00f3n<\/span> Ambiental.<\/span><\/span><\/p>\n

Publicaciones<\/span><\/span>:
<\/strong>Kupferman J, Ram\u00edrez-Rubio O, Amador JJ, L\u00f3pez-Pilarte D, Wilker EH, Laws RL, Sennett C, Robles NV, Lau JL, Salinas AJ, Kaufman JS, Weiner DE, Scammell MK, McClean MD, Brooks DR, & Friedman DJ (2018).\u00a0<\/span> Lesi\u00f3n renal aguda en trabajadores de la ca\u00f1a de az\u00facar en riesgo de nefropat\u00eda mesoamericana<\/a><\/span>.\u00a0<\/span>American Journal of Kidney Diseases<\/em>,\u00a0<\/span>72<\/em>(4), 475\u2013482.<\/p>\n

Kupferman J, Amador JJ, Lynch KE, Laws RL, L\u00f3pez-Pilarte D, Ram\u00edrez-Rubio O, Kaufman JL, Lau JL, Weiner DE, Robles NV, Verma KP, Scammell MK, McClean MD, Brooks DR, & Friedman DJ (2016).\u00a0<\/span>Caracterizaci\u00f3n de la nefropat\u00eda mesoamericana en un punto cr\u00edtico de insuficiencia renal en Nicaragua<\/a><\/span>.\u00a0<\/span>American Journal of Kidney Diseases<\/em>,\u00a0<\/span>68<\/em>(5), 716\u2013725.<\/p>\n

Laws RL, Brooks DR, Amador JJ, Weiner DE, Kaufman JS, Ram\u00edrez-Rubio O, Riefkohl A, Scammell MK, L\u00f3pez-Pilarte D, S\u00e1nchez JM, Parikh CR, & MD (2016). <\/span>Biomarcadores<\/span> de <\/span>lesi\u00f3n<\/span> renal entre <\/span>los<\/span> <\/span>trabajadores<\/span> <\/span>nicarag\u00fcenses<\/span> de la <\/span>ca\u00f1a<\/span> de <\/span>az\u00facar.<\/span><\/span><\/a>\u00a0<\/span>American Journal of Kidney Diseases<\/em>,\u00a0<\/span>67<\/em>(2), 209\u2013217.<\/p>\n

Laws RL, Brooks DR, Amador JJ, Weiner DE, Kaufman JS, Ram\u00edrez-Rubio O, Riefkohl A, Scammell MK, L\u00f3pez-Pilarte D, S\u00e1nchez JM, Parikh CR, & McClean MD (2015).\u00a0<\/span>Cambios<\/span> <\/span>en<\/span> la <\/span>funci\u00f3n<\/span> renal entre <\/span>los<\/span> <\/span>trabajadores<\/span> <\/span>nicarag\u00fcenses<\/span> de la <\/span>ca\u00f1a<\/span> de <\/span>az\u00facar<\/span>.<\/span><\/a>\u00a0<\/span>International Journal of\u00a0<\/span><\/em>Occupational and Environmental Health<\/em>,\u00a0<\/span>21<\/em>(3), 241\u2013250.<\/p>\n","protected":false},"excerpt":{"rendered":"

En Centroam\u00e9rica se ha descrito una epidemia de enfermedad renal cr\u00f3nica (ERC) de etiolog\u00eda desconocida entre los trabajadores agr\u00edcolas j\u00f3venes de sexo masculino. Aunque se han formulado muchas hip\u00f3tesis sobre causas ocupacionales y no ocupacionales (por ejemplo, estr\u00e9s t\u00e9rmico, metales pesados), el agente etiol\u00f3gico sigue siendo desconocido. Los objetivos de este proyecto fueron: (1) evaluar […]<\/p>\n","protected":false},"author":19802,"featured_media":0,"parent":58,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/buckdntresearch-es\/wp-json\/wp\/v2\/pages\/85"}],"collection":[{"href":"https:\/\/sites.bu.edu\/buckdntresearch-es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/buckdntresearch-es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/buckdntresearch-es\/wp-json\/wp\/v2\/users\/19802"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/buckdntresearch-es\/wp-json\/wp\/v2\/comments?post=85"}],"version-history":[{"count":6,"href":"https:\/\/sites.bu.edu\/buckdntresearch-es\/wp-json\/wp\/v2\/pages\/85\/revisions"}],"predecessor-version":[{"id":906,"href":"https:\/\/sites.bu.edu\/buckdntresearch-es\/wp-json\/wp\/v2\/pages\/85\/revisions\/906"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/buckdntresearch-es\/wp-json\/wp\/v2\/pages\/58"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/buckdntresearch-es\/wp-json\/wp\/v2\/media?parent=85"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}