{"id":423,"date":"2015-06-16T09:47:31","date_gmt":"2015-06-16T13:47:31","guid":{"rendered":"https:\/\/sites.bu.edu\/bryantlab\/?page_id=423"},"modified":"2017-08-15T10:38:31","modified_gmt":"2017-08-15T14:38:31","slug":"neema-yazdani","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/bryantlab\/people\/former-members\/neema-yazdani\/","title":{"rendered":"Neema Yazdani"},"content":{"rendered":"

\"Neema<\/p>\n

Biomolecular Pharmacology Graduate Student<\/p>\n

I am currently a fifth\u00a0year doctoral candidate in department of Pharmacology and Experimental Therapeutics at Boston University School of Medicine. Before BU, I attended the University of California, San Diego (UCSD), where I obtained a B.S. in Physiology and Neuroscience (2011) and an M.S. in Neuroscience (2012). During my undergraduate years, I participated the leech genome project, where I localized the expression of newly discovered gap junction Innexin genes to specific neurons in the embryonic leech central nervous system. For my Master\u2019s research, I studied the functional relationship between invertebrate Innexins, and vertebrate Connexins and Pannexins through site-directed mutagenesis of pan-neuronally expressed Innexin 1 and glia-expressed Innexin 2, eventually leading to the discovery of dominant negative gap junction mutants. Currently, I am pursuing my doctoral studies under the mentorship of Dr. Camron Bryant in the Laboratory of Addiction Genetics at Boston University School of Medicine. Upon joining the lab, a major research aim of mine was to determine which of two candidate genes, Rufy1<\/em> and Hnrnph1<\/em>, is involved in decreased methamphetamine sensitivity of C57BL\/6JxDBA\/2J congenic mice. Using customized transcription activator-like effector nucleases (TALENs), we knocked-out each respective gene in the C57BL\/6J strain, and determined Hnrnph1<\/em> to be our lead\u00a0candidate. Extending our findings beyond drug sensitivity into addiction-relevant behaviors, we are conducting a variety of behavioral assessments with Hnrnph1<\/em> TALENs mice, including conditioned place preference, intravenous self-administration, and oral self-administration. Through interdisciplinary approaches including\u00a0transcriptomic, immunohistochemical and neurochemical analyses, we will also investigate the neurobiological mechanisms underlying complex behavior.<\/p>\n","protected":false},"excerpt":{"rendered":"

Biomolecular Pharmacology Graduate Student I am currently a fifth\u00a0year doctoral candidate in department of Pharmacology and Experimental Therapeutics at Boston University School of Medicine. Before BU, I attended the University of California, San Diego (UCSD), where I obtained a B.S. in Physiology and Neuroscience (2011) and an M.S. in Neuroscience (2012). During my undergraduate years, […]<\/p>\n","protected":false},"author":9035,"featured_media":0,"parent":611,"menu_order":33,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/bryantlab\/wp-json\/wp\/v2\/pages\/423"}],"collection":[{"href":"https:\/\/sites.bu.edu\/bryantlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/bryantlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/bryantlab\/wp-json\/wp\/v2\/users\/9035"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/bryantlab\/wp-json\/wp\/v2\/comments?post=423"}],"version-history":[{"count":8,"href":"https:\/\/sites.bu.edu\/bryantlab\/wp-json\/wp\/v2\/pages\/423\/revisions"}],"predecessor-version":[{"id":1299,"href":"https:\/\/sites.bu.edu\/bryantlab\/wp-json\/wp\/v2\/pages\/423\/revisions\/1299"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/bryantlab\/wp-json\/wp\/v2\/pages\/611"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/bryantlab\/wp-json\/wp\/v2\/media?parent=423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}