{"id":174,"date":"2019-07-05T15:23:54","date_gmt":"2019-07-05T19:23:54","guid":{"rendered":"https:\/\/sites.bu.edu\/biomicroscopy\/?page_id=174"},"modified":"2019-07-15T09:41:26","modified_gmt":"2019-07-15T13:41:26","slug":"retinal","status":"publish","type":"page","link":"https:\/\/sites.bu.edu\/biomicroscopy\/research\/retinal\/","title":{"rendered":"Transcranial retinal imaging"},"content":{"rendered":"<figure id=\"attachment47\" aria-describedby=\"caption-attachment47\" style=\"width: 328px\" class=\"wp-caption alignright\"><img loading=\"lazy\" src=\"\/biomicroscopy\/files\/2019\/06\/Ill-be-back.gif\" alt=\"\" class=\"wp-image-47 size-full\" width=\"318\" height=\"274\" \/><figcaption id=\"caption-attachment47\" class=\"wp-caption-text\">I&#8217;ll be back&#8230;.<\/figcaption><\/figure>\n<p>Widefield human retinal imaging is typically performed in a reflection geometry, where light is delivered through the pupil and images are formed from the light reflected back from the retina. In this configuration, artifacts caused by retinal surface back-reflections are often encountered, which complicate quantitative interpretation of the reflection images.<\/p>\n<p>We have developed an alternative widefield retinal imaging technique based on near-infrared light delivered transcranially through the subject\u2019s temple. The light diffuses through the bone and illuminates the retina not from the front, as in standard techniques, but rather mostly from the back. As such, images are formed from light transmitted through the retina rather than reflected from the retina. This unique transmission geometry simplifies absorption pathlength considerations and enables flash-free, non-mydriatic imaging as deep as the choroid. Multiple wavelengths may be used enabling measurement of blood oxygen saturation in retinal vessels.<\/p>\n<figure id=\"attachment52\" aria-describedby=\"caption-attachment52\" style=\"width: 646px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" src=\"\/biomicroscopy\/files\/2019\/06\/Retina-636x636.png\" alt=\"\" class=\"wp-image-52 size-medium\" width=\"636\" height=\"636\" srcset=\"https:\/\/sites.bu.edu\/biomicroscopy\/files\/2019\/06\/Retina-636x636.png 636w, https:\/\/sites.bu.edu\/biomicroscopy\/files\/2019\/06\/Retina-150x150.png 150w, https:\/\/sites.bu.edu\/biomicroscopy\/files\/2019\/06\/Retina-768x768.png 768w, https:\/\/sites.bu.edu\/biomicroscopy\/files\/2019\/06\/Retina.png 875w\" sizes=\"(max-width: 636px) 100vw, 636px\" \/><figcaption id=\"caption-attachment52\" class=\"wp-caption-text\">Map of oxygen saturation in major retinal blood vessels.<\/figcaption><\/figure>\n<ul>\n<li>T. D. Weber and J. Mertz, &#8220;Non-mydriatic chorioretinal imaging in a transmission geometry and application to retinal oximetry&#8221;, Biomed. Opt. Express 9, 3867-3882 (2018). <a href=\"https:\/\/www.osapublishing.org\/boe\/abstract.cfm?uri=boe-9-8-3867\">link<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Widefield human retinal imaging is typically performed in a reflection geometry, where light is delivered through the pupil and images are formed from the light reflected back from the retina. In this configuration, artifacts caused by retinal surface back-reflections are often encountered, which complicate quantitative interpretation of the reflection images. We have developed an alternative [&hellip;]<\/p>\n","protected":false},"author":16427,"featured_media":0,"parent":98,"menu_order":16,"comment_status":"closed","ping_status":"closed","template":"page-templates\/profiles.php","meta":[],"_links":{"self":[{"href":"https:\/\/sites.bu.edu\/biomicroscopy\/wp-json\/wp\/v2\/pages\/174"}],"collection":[{"href":"https:\/\/sites.bu.edu\/biomicroscopy\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.bu.edu\/biomicroscopy\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/biomicroscopy\/wp-json\/wp\/v2\/users\/16427"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/biomicroscopy\/wp-json\/wp\/v2\/comments?post=174"}],"version-history":[{"count":6,"href":"https:\/\/sites.bu.edu\/biomicroscopy\/wp-json\/wp\/v2\/pages\/174\/revisions"}],"predecessor-version":[{"id":446,"href":"https:\/\/sites.bu.edu\/biomicroscopy\/wp-json\/wp\/v2\/pages\/174\/revisions\/446"}],"up":[{"embeddable":true,"href":"https:\/\/sites.bu.edu\/biomicroscopy\/wp-json\/wp\/v2\/pages\/98"}],"wp:attachment":[{"href":"https:\/\/sites.bu.edu\/biomicroscopy\/wp-json\/wp\/v2\/media?parent=174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}