URBAN ARCH Newsletter

Volume 4, Issue 1

January 2017 – March 2017


Check out the current issue of URBAN ARCH News, the quarterly newsletter bringing you news based on the latest URBAN ARCH and related research.


Russia ARCH – St PETER HIV

Collage

This issue of the URBAN ARCH quarterly newsletter will focus on the new Russia ARCH study – St PETER HIV. Click here to learn more.


In the News


Spotlight On…Hilary Tindle

In this issue, we interview Hilary Tindle, MD, MPH, Co-Principal Investigator of the St. PETER HIV study and Associate Professor of Medicine at Vanderbilt University.

 


On The Ground

Click on the buttons to see what the URBAN ARCH Cohorts and Cores have been working on.



2017 URBAN ARCH Annual Meeting

There’s still time to RSVP! The sixth URBAN ARCH Annual Meeting will be held on March 28-29, 2017. Click here for more information about this meeting.


New URBAN ARCH Publications


New FeatureArticle Spotlight
This new section will highlight and provide brief summaries of URBAN ARCH research and their clinical significance

Longitudinal association between alcohol use and inflammatory biomarkers

Few studies have examined the association between heavy alcohol use and biomarkers of inflammation (interleukin-6; IL-6), monocyte activation (soluble CD14; sCD14), and altered coagulation (D-dimer) among people with HIV. The Russia Alcohol Research Collaboration on HIV/AIDS (ARCH) study evaluated this association over time among 350 people with HIV who had not previously received antiretroviral therapy. Participants were mostly male (71%) with a mean age of 34 years; 77% had heavy drinking (defined as >14 drinks/week or 4 drinks/day [men], and >7 drinks/week or >3 drinks/day [women]), 87% had hepatitis C virus, and 86% had smoking.

  • Heavy drinking was associated with elevated biomarkers IL-6, sCD14, and D-dimer in adjusted models over time.
  • Changes in alcohol consumption after 1 year were not significantly associated with changes in these biomarkers compared with participants with no changes in consumption.

Comments: Since these biomarkers predict mortality, interventions to mitigate effects of heavy drinking on these immune processes merit consideration.

Reference: So-Armah K, Freiberg M, Cheng D, Patts G, Tracy R, Doyle M, Gnatienko N, Bryant K, Krupitsky E, Samet JH. Longitudinal association between alcohol use and inflammatory biomarkers. 2017; Poster presentation at the Conference on Retroviruses and Opportunistic Infections; Seattle, WA.


Selected NIH Notices and Funding Opportunities

  • NIDA Avant-Garde Award Program for HIV/AIDS and Drug Use Research (DP1) (RFA-DA-18-001)
    National Institute on Drug Abuse
    Application Due Date: July 31, 2017
  • Advancing Exceptional Research on HIV/AIDS and Substance Abuse (R01) (RFA-DA-18-002)
    National Institute on Drug Abuse
    Application Due Date: August 22, 2017
  • Advancing Interventions to Improve Medication Adherence (R01) (PA-14-334) and (R21) (PA-14-335)
    National Institute on Alcohol Abuse and Alcoholism, Office of Behavioral and Social Sciences Research
    Application Due Date: Standard Dates

Click here for more funding announcements related to HIV and alcohol research.


Events and Conferences

Please email Carly Bridden if you will be attending any these meetings, so we can connect you with our investigators.

Click here for more events and conferences.


Featured Resources