Scleroderma Trials from

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Clinical Trial Number Title
01959815 Novel Screening Strategies for Scleroderma PAH
01943968 Lysyl Oxidase, Semaphorin 7a and Semaphorin 3a in Patients With Systemic Sclerosis
01935726 Pulmonary Fibrosis Contact Registry
01933334 Safety and Tolerability of Pirfenidone in Patients With Systemic Sclerosis?Related Interstitial Lung Disease (SSc-ILD) (LOTUSS)
01918904 A Pilot Study to Evaluate Topical Sodium Thiosulfate Therapy for Calcinosis Cutis
01910818 Pilot Study of the Effect of Laser on Reversing Chronic Radiation Injury
01895244 Highdose Chemotherapy and Transplantation of 34+ Selected Stem Cell for Progressive Systemic Sclerosis – Modification According to Manifestation
01884051 Hormonal, Metabolic, and Signaling Interactions in PAH
01881529 A Non-Interventional Pilot Study Assessing Whether Lysyl Oxidase-like 2 (LOXL2) is Present in Subjects With Scleroderma
01878526 Gastroesophageal Reflux Treatment in Scleroderma
01862926 Rituximab Versus Cyclophosphamide in Connective Tissue Disease-ILD
01858259 Prevention and Treatment of Interstitial Lung Disease in Systemic Sclerosis
01848418 Conception of an ICF Core Set for Systemic Sclerosis
01840748 Development and Prevention of Pulmonary Hypertension in Systemic Sclerosis
01836263 Prevention and Treatment of Digital Ulcers in Systemic Sclerosis
01834157 Improvement of Hand Dysfunction by Arthritis in Systemic Sclerosis
01829126 Development and Prevention of Severe Heart Disease in Systemic Sclerosis
01827059 Bosentan In Exercise Induced Pulmonary Arterial Hypertension in CongenitaL Heart diseasE
01817361 Oral Health and People With Systemic Sclerosis
01813578 Effects of Intensive Aerobic and Muscle Endurance Exercise in Patients With Systemic Sclerosis – a Pilot Study
01813279 Assessment of the Subcutaneous Reinjection of Human Autologous Adipose-derived Stromal Vascular Fraction (CelutionÆ System) in the Hands of Patients Suffering From Systemic Sclerosis
01808937 Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
01804959 Clinical Trial of Probiotics in Systemic Sclerosis Associated Gastrointestinal Disease
01799174 Treatment Study Comparing UVA-1 Phototherapy Versus Placebo Treatment for Morphea
01789151 99m-Technetium- Glucosamine in Arthritis
01785056 IVIG Treatment in Systemic Sclerosis
01762449 Morbidity and Mortality Follow Up for the Scleroderma Lung Study
01758250 Microvascular and Fibrosis Imaging Study
01757522 Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS)
01748084 Rituximab in Systemic Sclerosis
01743612 Laser Speckle Contrast Imaging for Cutaneous Microvascular Dysfunction Detection in Systemic Sclerosis.
01733056 Immune Response to Vaccination in Patients Receiving Single Drug Immunosuppression
01729611 Endothelial Function in Patients With Scleroderma or Cirrhosis With and Without Pulmonary Hypertension
01697254 The CARRA Registry
01673633 Sacroiliitis in Systemic Sclerosis
01670565 Belimumab for the Treatment of Diffuse Cutaneous Systemic Sclerosis
01667042 Scleroderma Lung: Role of Gastroesophageal Reflux, Microaspiration and Cough
01663129 Steroid-Induced Osteoporosis in the Pediatric Population – Canadian Incidence Study
01656447 Scleroderma Registry & Repository at the Hospital for Special Surgery
01651143 Proof of Biological Activity of SAR100842 in Systemic Sclerosis
01642706 Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments
01639573 Campath-1h Phase I/II Pilot Trial as Immunoablative Therapy for Refractory Systemic Sclerosis
01586663 Serial Night Time Position Splint on Systemic Sclerosis
01570764 Cyclophosphamide Systemic Sclerosis Associated Interstitial Lung Disease
01570647 Automated Connective Tissue Torque Sensor
01559129 Study of Pomalidomide (CC-4047) to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Effectiveness for Subjects With Systemic Sclerosis With Interstitial Lung Disease
01554540 Treprostinil Iontophoresis : a Pharmacodynamic and Pharmacokinetic Study
01553981 A Trial of Tadalafil in Interstitial Lung Disease of Scleroderma
01553890 Empirical Comparative Study of Variation Blood Level Antibody Vitamin D at Scleroderma (SSc) Patients Compared Healthy Peoples
01545427 Proof of Concept Trial of Gleevec (Imatinib) in Active Diffuse Scleroderma
01538719 IL1-TRAP, Rilonacept, in Systemic Sclerosis
01532869 A Study of RoActemra/Actemra (Tocilizumab) Versus Placebo in Patients With Systemic Sclerosis
01520493 Peripheral Muscle Microcirculation and Exercise-induced Blood Flow Distribution in Pulmonary Arterial Hypertension
01497743 Probiotics in Patients With Moderate-to-severe Distention/ Bloating From Systemic Sclerosis
01488214 Neuropsychiatric Scleroderma Study: Systematic Evaluation of Neuropsychiatric Involvement in Systemic Sclerosis
01487551 An Open-Label Study to Evaluate Biomarkers and Safety in Systemic Sclerosis Patients Treated With ABR-215757 (Paquinimod)
01474122 Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients
01474109 Macitentan for the Treatment of Digital Ulcers in Systemic Sclerosis Patients
01468792 Hemodynamic Changes in Connective Tissue Disease
01445821 Autologous Stem Cell Systemic Sclerosis Immune Suppression Trial
01424033 Evaluating N-Acetylcysteine in CTD-ILD Treatment
01413100 Scleroderma Treatment With Autologous Transplant (STAT) Study
01410903 Immunoadsorption in Patients With Severe Systemic Sclerosis
01395732 Bosentan in Systemic Sclerosis
01393132 Comparative Study of Thymosin Beta 4 Eye Drops vs. Vehicle in the Treatment of Severe Dry Eye
01389271 Inhaled Iloprost in the Treatment of Patients With Pulmonary Hypertension up to 4 Years
01387035 Early Diagnosis of Pulmonary Hypertension in Patients With Inflammatory Rheumatic Connective Tissue Diseases
01377090 Digital Ulceration
01374282 Post Marketing Surveillance Study of Cuprimine
01347008 Effect of Sildenafil on the Microcirculatory Blood Flow and Endothelial Progenitor Cells in Systemic Sclerosis
01315899 Efficacy of ORM-12741 for Prevention of Raynaud’s Phenomenon
01309997 Imatinib and Rituximab in Treating Cutaneous Sclerosis in Patients With Chronic Graft-Versus-Host Disease
01295736 Sildenafil Effect on Digital Ulcer Healing in sClerodErma SEDUCE STUDY
01284322 Fresolimumab In Systemic Sclerosis
01270425 Sonographic and Laboratory Evaluation of the Thyroid Gland in Patients With Systemic Sclerosis
01257802 GnRH-a for Ovarian Protection During CYC Therapy for Rheumatic Diseases
01241383 Effect of Bosentan in Scleroderma Renal Crisis
01233999 Botulinum Toxin in the Treatment of Raynaud’s
01208792 Auto-immunity and Pulmonary Arterial Hypertension
01202045 Stress Echocardiography in the Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis Patients
01166139 Nilotinib in the Treatment of Systemic Sclerosis
01151644 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases
01133730 Transversalis Fascial Plane Nerve Block in Iliac Crest Bone Graft
01117298 A Randomized Control Trial to Assess the Efficacy of Tadalafil in Raynaud’s Phenomenon in Scleroderma
01111786 Finger Hardness Measure in Scleroderma
01093885 Study of Ambrisentan With Antifibrotic Agent Combination Therapy in Diffuse Systemic Sclerosis
01090492 PF-00489791 For The Treatment Of Raynaud’s
01086540 Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)
01072669 Efficacy of Ambrisentan in Limited Scleroderma Patients in Improving Blood Flow to Hands or Feet
01051960 Exercise Induced Pulmonary Hypertension in Systemic Sclerosis and Treatment With Ambrisentan
01047072 Low-Dose Conditioning Followed by Donor Stem Cell Transplant in Treating Patients With Severe Systemic Sclerosis
01042158 A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis
01025739 Evaluation of the Safety and Effectiveness of Tailored Transoral Incisionless Fundoplication (TIF) Using EsophyX for the Treatment of GERD
01002508 Influenza Vaccination in Patients With Scleroderma
00984932 Effect of Rosuvastatin on Systemic Sclerosis-related Pulmonary Hypertension
00962923 Allogeneic Mesenchymal Stem Cells Transplantation for Systemic Sclerosis (SSc)
00958672 Small Intestinal Mucosal Abnormalities in Systemic Sclerosis Using Capsule Endoscopy
00946738 The Effect of Physical Therapy on Raynaud`s Phenomenon Secondary to Systemic Sclerosis
00946699 A Study of the Safety and Tolerability of MEDI-551 in Scleroderma
00936546 A Protocol Based Treatment for Debilitating Fibrosing Skin Disorders With (Anti-CD 20), Rituximab, Evaluating Safety and Efficacy
00934427 Study of a Topical Formulation for the Treatment and Prevention of Raynaud’s Phenomenon Symptoms
00930683 A Study to Evaluate Safety and Tolerability of Multiple Doses of MEDI-546 in Adult Subjects With Scleroderma
00909337 Early Therapy of Pulmonary Arterial Hypertension
00883129 Comparison of Therapeutic Regimens for Scleroderma Interstitial Lung Disease (The Scleroderma Lung Study II)
00860548 SCOT Scleroderma Treatment Alternative Registry (STAR Registry)
00853788 Skin Biopsy Specimens as Biomarkers of Systemic Sclerosis and Response to Mycophenolate Mofetil
00849745 Nonmyeloablative Allo Stem Cell Transplant for Severe Autoimmune Diseases
00848939 Pharmacokinetics of Oral Treprostinil in Patients With Systemic Sclerosis
00848107 Open-Label Study of Oral Treprostinil in Digital Ulcers
00843102 Investigation of Coronary and Pulmonary Circulatory Parameters in Systemic Sclerosis
00837473 Study Performance of The Plexur Pô Bone Void Filler Device in Patients Undergoing Iliac Crest Harvesting Procedures
00812188 Treatment Study Comparing Medium or High Dose Uva-1 Treatment 3x/Week Versus Fluocinonide 0.05% Cream in the Treatment of Morphea.
00781053 Open Label Extension (OLE) for the Patients Treated in the ISD002-P144-07 Study
00775463 Digital Ischemic Lesions in Scleroderma Treated With Oral Treprostinil Diethanolamine
00769028 AIMSPRO in Established Diffuse Cutaneous Systemic Sclerosis
00764309 Safety Evaluation of Dasatinib in Subjects With Scleroderma Pulmonary Fibrosis
00740311 Filling of Tooth Sockets With MBCP Gel TM Versus Technical Without Filling
00740285 Effectiveness and Safety of Lidocaine for Scleroderma
00725361 A Study to Evaluate the Efficacy of an Oral Medication in the Treatment and Prevention of Digital Ulcers in Patients With Systemic Sclerosis (Scleroderma).
00707187 Trial of IC351 in Female Scleroderma Patients With Raynaud’s and Sexual Dysfunction
00706082 Early, Simple and Reliable Detection of Pulmonary Arterial Hypertension (PAH) in Systemic Sclerosis (SSc)
00704665 Recombinant Human Relaxin in the Treatment of Diffuse Scleroderma
00697736 Cardiac Repercussion of Systemic Sclerodermias
00684255 Reduced Intensity Transplant in Medically Refractory Systemic Lupus Erythematosus (SLE) and Systemic Sclerosis (SSc)
00668473 Angiogenic/Angiostatic Mediators in Patients With Systemic Sclerosis
00667134 Stimulatory Autoantibodies to the Platelet-Derived Growth Factor Receptor (PDGFR) and Phosphorylation of the Platelet-Derived Growth Factor Receptor (PDGFR) in Patients With Systemic Sclerosis
00656825 Tolerability and Bioavailability of the P144 Peptide Inhibitor of TGF-?1 After Topical Administration in Healthy Volunteers
00628797 Effectiveness of UVA1-irradiation in the Treatment of Early Skin Fibrosis in Patients Suffering From Systemic Sclerosis
00626665 Randomised Control Trial to Assess the Efficacy of Tadalafil in Raynaud’s Phenomenon in Scleroderma
00624273 Sildenafil for Treatment of Digital Ulcers in Patients With Systemic Sclerosis
00622895 Allogeneic Hematopoietic Cell Transplantation After Nonmyeloablative Conditioning for Patients With Severe Systemic Sclerosis
00622687 Effect of Different Iloprost Doses on Symptoms in Systemic Sclerosis
00617487 Pulmonary Arterial Hypertension in Systemic Sclerosis
00613171 Efficacy and Tolerability of STI571 (Imatinib Mesylate) for the Treatment of Fibrosis in Patients With Systemic Sclerosis
00595049 Pulmonary Artery Remodelling With Bosentan
00581997 QAX576 in Patients With Pulmonary Fibrosis Secondary to Systemic Sclerosis
00578578 Trial to Study the Effects of Supplementary Omega-3 on Serum C-Reactive Protein Levels
00577304 A Study of a Topical Form of Nitroglycerin and Placebo in the Treatment and Prevention of Raynaud’s Phenomenon
00574613 Efficacy and Safety Study of p144 to Treat Skin Fibrosis in Systemic Sclerosis
00573326 Low-Dose Oral Imatinib for Scleroderma Pulmonary Involvement
00566137 Sleep Disturbances and Pulmonary Artery/Aorta Diameter in Scleroderma Patient
00555581 Imatinib Mesylate (Gleevec) in the Treatment of Systemic Sclerosis
00540566 Optical Biopsy of Human Skin in Conjunction With Laser Treatment
00522002 CLUE Study: Connective Tissue Disease Leg Ulcer Etiology Study
00513591 Duke Autoimmunity in Pregnancy Registry
00512902 A Study Using The Experimental Drug Called Imatinib (Gleevec) in Subjects With Systemic Sclerosis
00506831 Imatinib in Systemic Sclerosis
00501995 High Dose Cyclophosphamide for Treatment of Scleroderma
00498615 A Rho-kinase Inhibitor (Fasudil) in the Treatment of Raynaud’s Phenomenon
00480753 Dose Response Study of a Topical Formulation of Nitroglycerin for the Treatment of Raynaud’s Phenomenon
00479934 Efficacy and Safety of Imatinib in Scleroderma
00476801 UVA1 Light for Treatment of Scleroderma and Similar Conditions
00476697 UVA1 Light for Scleroderma and Similar Conditions
00472225 Study of Rituximab in Patients With Steroid-Refractory Chronic Graft-Versus-Host Disease
00463125 Platelet Gel in Systemic Sclerosis
00453752 Non-Invasive Diagnostic and Functional Evaluation of Cardiac Involvement in Patients With Systemic Sclerosis
00442611 A Study to Evaluate the Safety and Efficacy of Abatacept in Patients With Diffuse Systemic Sclerosis (Scleroderma)
00433186 Mycophenolate Mofetil in Systemic Sclerosis
00428883 High Dose Intravenous N-Acetylcysteine Versus Iloprost for Early, Rapidly Progressive Diffuse Systemic Sclerosis
00419419 Phase III Study of a Topical Gel Formulation for Treatment and Prevention of Raynaud’s Phenomenon
00418132 Thalidomide for Decreasing Collagen Biosynthesis in People With Progressive Systemic Sclerosis
00379431 A Protocol Based Treatment for Early and Severe Systemic Sclerosis With (Anti-CD20), Rituximab
00378521 Dose Response Study of a Topical Gel for the Treatment of Raynaud’s Phenomenon
00377949 Multi-center, Web Based Observational Study of Pulmonary Hypertension in Scleroderma Patients
00377455 Placebo Controlled Trial of Bosentan in Scleroderma Patients
00372398 Premature Coronary Atherosclerosis in Scleroderma
00348296 Efficacy and Safety Study of GB-0998 for Treatment of Systemic Sclerosis
00341198 Confirmation of Systemic Autoimmune Diseases in the Agricultural Health Study
00333437 Pulmonary Involvement in Scleroderma: A Clinical Study of the Safety and Efficacy of Mycophenolate Mofetil in Scleroderma Patients With Lung Involvement
00319696 Bosentan in Digital Ulcers
00319033 Open-label Study With Bosentan in Interstitial Lung Disease
00318188 Effects of a Personalized Standardized Rehabilitation Program in Systemic Sclerosis
00318175 Effect of Bosentan on Skin Fibrosis in Patients With Systemic Sclerosis
00282425 Allogeneic Hematopoietic Stem Cell Transplantation (NST) for Patients With Systemic Sclerosis
00278525 Cyclophosphamide and rATG With Hematopoietic Stem Cell Support in Systemic Scleroderma
00266669 Phase III Study of Topical Gel for Treatment and Prevention of Raynaud’s Phenomenon
00253331 Lab Study of MQX-503 in Treatment of Raynaud’s
00241189 Rapamycin Vs Methotrexate in Diffuse SSc
00230373 Imiquimod 5% Cream in Plaque-Type Morphea: A Pilot, Prospective Open-Label Study
00226889 Treatment of Early Systemic Sclerosis by Bosentan
00213525 Genesis of Scleroderma: Role of Environmental Factors in 100 Patients With Scleroderma and 300 Controls
00213460 Small Bowel Motor Impairment in Scleroderma: Results of a Prospective 5-year Manometric Follow-up
00204763 Comparison of Esophageal and Anorectal Manometry Catheters
00174057 The Role of TSH Receptor, PPAR-r, IGF-1R, IGF and Cytokines in Different Stages of GravesíOphthalmopathy
00147771 Imiquimod in Children With Plaque Morphea
00129428 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix
00129415 Ultraviolet (UVA and UVB) Light Therapy in the Treatment of Inflammatory Skin Conditions
00114530 Scleroderma: Cyclophosphamide or Transplantation (SCOT)
00080457 Safety and Efficacy Study of Sitaxentan Sodium (Thelinô) in Patients With Pulmonary Arterial Hypertension
00077584 Efficacy and Safety of Oral Bosentan on Healing/Prevention of Digital (Finger) Ulcers in Scleroderma Patients
00074568 Scleroderma Registry
00070590 Efficacy and Safety of Oral Bosentan in Pulmonary Fibrosis Associated With Scleroderma
00058578 Stem Cell Transplant to Treat Patients With Systemic Sclerosis
00055055 Study of Families With Twins or Siblings Discordant for Rheumatic Disorders
00048776 Safety and Efficacy of Pletal (Cilostazol) for the Treatment of Juvenile Primary and Secondary Raynaudís Phenomenon
00043706 Safety, Tolerability, and Pharmacokinetics of CAT-192 (Human Anti-TGF-Beta1 Monoclonal Antibody) in Patients With Early Stage Diffuse Systemic Sclerosis
00040651 Safety and Value of Self Bone Marrow Transplants Following Chemotherapy in Scleroderma Patients
00025818 Six Month Clinical Research Study for Patients With Moderate or Severe Dry Eye Syndrome
00016458 Phase II Pilot Study of Cyclophosphamide and Rabbit Anti-Thymocyte Globulin as Salvage Therapy in Patients With Diffuse Systemic Sclerosis
00010335 Pilot Study of Total Body Irradiation in Combination With Cyclophosphamide, Anti-thymocyte Globulin, and Autologous CD34-Selected Peripheral Blood Stem Cell Transplantation in Children With Refractory Autoimmune Disorders
00007267 Psychological Treatments for Scleroderma
00006393 Genetic Study of the FBN1 Gene and Fibrillin-1 Abnormalities in Choctaw Native Americans and Other Patients With Systemic Sclerosis
00005675 Oral Type I Collagen for Relieving Scleroderma
00005317 Idiopathic Pulmonary Fibrosis–Pathogenesis and Staging – SCOR in Occupational and Immunological Lung Diseases
00004786 Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Iloprost for Raynaud’s Phenomenon Secondary to Systemic Sclerosis
00004563 Scleroderma Lung Study
00004380 Phase II Study of Recombinant Relaxin for Progressive Systemic Sclerosis
00001330 Study of Silicone-Associated Connective Tissue Diseases