Laboratory


677 Beacon St., Rooms 302 and 308
Boston, MA 02215
phone: (617) 358-8110
phone: (617) 358-8111
lab email: cogneuro@bu.edu

 

Equipment & Resources


Our laboratory is outfitted with multiple private rooms for participant screening, electroencephalogram (EEG, Brain Products), cap set-up, and administration of noninvasive electrical brain stimulation. We have a 9-channel M x N high-definition transcranial electrical stimulator (HD-tES; Soterix Medical), complete with accessories (e.g., connecting cables, HD electrodes, HD holders, Easycaps, Signa gel, Easycase, batteries, etc.). This high-end neuromodulation platform allows for high-definition direct-current, alternating-current, oscillatory direct-current, pulse current, and random-noise stimulation procedures. Our laboratory is also equipped with a 32-channel M x N high-definition transcranial electrical stimulator (32-chan HD-tES), which provides highly flexible montage configurations and custom waveform generation. Further, we have an interferential or temporal interference stimulator, which promises noninvasive stimulation at depth based on the summation of two high frequency sine waves of slightly different frequencies resulting in a waveform that is a high frequency carrier-wave modulated by a low frequency envelope oscillating at a “beat” frequency. In addition, Soterix Medical and our laboratory have collaborated to create custom trigger solution hardware and related Matlab software for the temporal synchronization between HD-tES and the Brain Products EEG system. Our laboratory is also equipped with HD-Targets and HD-Explore neurotargeting software packages (Soterix Medical), CURRY 7.0 multimodal neuroimaging software (Compumedics Neuroscan), and Brain Vision Analyzer II EEG software (Brain Products).
For behavioral and electrophysiological data acquisition, our laboratory has two state-of-the-art, electrically shielded, sound-attenuated chambers (9’L x 7’W x 8’H; ETS Lindgren) for high capacity data collection, equipped with visual monitoring of participants, and audio systems enabling participant-researcher communication at any time. Each recording chamber is equipped with a high-end PC for stimulus presentation and a high-end PC that performs data acquisition of the EEG data using Brain Products Recorder software. The stimuli are presented on 24-inch ASUS LED displays (144 Hz refresh rate, 1 ms response). Each recording chamber is also equipped with a Brain Products ActiChamp Amplifier with 160-channel capability, 24-bit resolution, twelve 32-channel arrays of active electrodes, and dozens of individual active electrodes. Twelve electrode caps of all adult sizes are available so that participants with the same size head can be run back-to-back. In addition, the laboratory is equipped with CapTrak electrode localization equipment (Brain Products) for coregistration of surface potentials with anatomical and functional imaging data to facilitate multimodal imaging and for increased precision of 3D locations of electrodes for EEG source reconstruction. Our laboratory contains timing utilities from Brain Products to ensure reliable timing accuracy between operating systems and video/audio hardware.cube9be97e8b-7641-4516-8e9b-24ada9846467
The laboratory is outfitted with additional suites for workspace containing two W599 Titan workstations (2 x Intel Xeon Gold 6154 SP 3.7 GHz, 36 Cores, 512 GB RAM, 12 TB; dedicated for multimodal, neurotargeting, EEG analysis software use, and computationally heavy processing), two W299 Titan workstations (Intel Core i9 9980XE Skylake X 4.4 GHz, 18 Cores, 128 GB RAM, 5 TB), five iMac 5K computers (32 GB RAM, 3 TB), four Dell XPS 7760 computers (64 GB RAM, 2 TB), and access to an EyeLink II infrared video eye tracker (SR Research) and laser printer. All computers have Matlab licenses so that they can be used for development of new experiments using Psychtoolbox and EEG data analysis. All computers have the custom package of software developed at UCSD for EEG data analysis that can be performed in the X11 Unix window environment. All computers have Matlab toolboxes installed including EEGLAB, ERPLAB, FieldTrip, and Brain Connectivity. In addition to our laboratory databases, we have an active project account with Boston University’s Shared Computing Cluster (SCC), a massively parallel high performance computer cluster, important for computationally intensive analyses of large datasets, allowing efficient analysis and processing of data.
Additionally, our laboratory has ready access to a Siemens MAGNETOM Prisma scanner, a state-of-the-art, whole-body superconductive Zero Helium Boil-off 3T magnet with a XR 80/200 gradient system with a 64 channel head coil. The scanner is located in the newly constructed Rajen Kilachand Center for Integrated Life Science and Engineering (1-minute walk from our laboratory) and supported by a number of dedicated MR technologists. The 3T scanner is equipped with a VPixx Tech PROPixx Lite projection system, an EyeLink 1000 Plus eye tracker, a Sensimetrics S15 auditory system, and BIOPAC physiological monitoring system. In the Kilachand Center, we have access to functional Near-Infrared Spectroscopy (fNIRS) equipment, and multiple cognitive neuroscience and RF-shielded physiological research rooms.