Researchers from the U.S. Department of Energy’s Brookhaven National Laboratory and Thomas Jefferson National Accelerator Facility, Oak Ridge National Laboratory, Johns Hopkins Medical School, the University of Maryland, and Weizmann Institute’s Neurobiology Department have all developed new and improved brain scanning techniques. These new methods allow scientists to monitor brain activity in fully-awake, moving animals.
At Brookhaven, researchers combined light-activated proteins that stimulate specific brain cells, a technique known as optogenetics, with positron emission tomography (PET) to observe the effects of stimulation throughout the entire brain. Their paper in the Journal of Neuroscience describes this method, which will allow researchers to map exactly which neurological pathways are activated or deactivated downstream by stimulation in specific brain areas. Hopefully, following these pathways will enable researchers to correlate the brain activity with observed behaviors or certain symptoms of disease.