Women have a pretty bad rep when it comes to hormones. We get it all the time, in memes, as jokes in TV shows, or in the form of the amusing side comment, “It’s that time of the month again, eh?” with a crass wink. Yes yes, females have a tendency to be moody. For whatever reason, this is a theme present throughout our genetic makeup. A recent study conducted at Indiana University shows that seasonal changes, particularly the fall to winter transition, are associated with a rise in aggressive behavior in female hamsters as opposed to male hamsters. This study revealed new mechanisms by which sex hormones are influenced by the nervous system and provides a model from which we can further study the male and female nervous systems.
The experimenters singled out melatonin as the hormone stimulating female adrenal glands to release hormones acting in place of the hormones released from the gonads. Things do not work this way for male hamsters when there’s a change of season. In females, they found some strange things about this system. The adrenal glands normally release an aggression hormone, DHEA, in response to the release of another hormone, ACTH, secreted by the pituitary gland. Once this seasonal change kicks in however, melatonin is the hormone that stimulates the release of DHEA, and it completely skips past the pituitary gland.
One group of hamsters in this experiment was exposed to the shorter day conditions of winter for ten weeks and then observed for aggressive behaviors. Not only were the female hamsters more aggressive than the males and the control group, but their chemistry had also changed. These aggressive ladies had higher levels of DHEA and melatonin in their bloodstreams and also displayed physical changes in their adrenal glands.
Given that hamsters happen to have similar adrenal systems to humans, these results give us much greater insight into how our own adrenal systems function and how they could be affected throughout the year. While it hasn’t been experimentally proven that these findings can be applied to humans as well, I think it definitely explains away my aggressive feelings during the cold dark months.
~ Jackie Rocheleau
You may have heard that it is a good idea for children to learn more than one language at a young age (especially toddlers) and that children learn languages more easily than adults. Why is it though, that learning early is advantageous for children? And is the claim that it is easier for children to learn languages than it is for adults true?
Like any other muscle, the more the brain exercises, the stronger it becomes. One way to strengthen the brain is by learning a language, memorizing rules and vocabulary. Research shows that children who learn additional languages have more creativity and flexibility and also possess better critical thinking skills compared to their non-foreign language learning peers, as these children outperform their peers in both verbal and mathematics standardized testing. Children should also learn more than one language because the brain is more open to new sounds and patterns at a young age, so children can mimic new sounds and adopt pronunciations more easily than adults.
Now, whether or not children learn language more easily than adults is up for debate. According to the much-debated “critical period hypothesis,” language development is similar to other forms of development, such as visual development, in that it has a critical period. At this critical period between childhood and adolescence, children can easily learn language, but when this period ends, learning becomes more difficult. Also, if a child fails to learn any language during this period, then the child’s capacity to develop language is permanently damaged and the neural basis for language development degenerates. Since this is only a hypothesis with limited evidence, whether or not this critical period actually exists is unknown. In any case, it certainly can’t hurt for a child to learn more than one language early and receive the clear mental benefits as a result.
~ Nathaniel Meshberg
A migraine headache is a severe unilateral and pulsating discomfort that is associated with extreme sensitivity to light, sound, smell, taste, and touch that generally lasts between 4 and 72 hours. According to Daniela Pietrobon and Jord Striessnig in “Neurobiology of Migraine,” migraines affect 6-8% of men and 15-25% of women in western countries. At least 1% of the population has a minimum of one day of migraine per week – which means around 2.5 million people in North America are sufferers. In fact, migraines are currently ranked as one of the most disabling chronic disorders. With such a high prevalence, it may seem peculiar how little is known about this condition. However, with the help of recent experimental studies, we are beginning to advance our understanding of the physiological and biological factors that contribute to triggering a migraine. Unfortunately, due to the lack of knowledge about this disease, there are many myths associated with it. I shall address some of these myths in the hope of broadening the general understanding of both the disease and its sufferers.
Myth 1: Migraines are simply bad headaches exaggerated by the sufferer.
Truth: Unfortunately, this is a common creed adopted by a vast majority of both the general public and many physicians. For the past century, there has been negative stigma placed on migraine sufferers. Society has long placed the blame of migraines on migraineurs, believing that their migraines are nothing more than headaches that are exaggerated by their sufferers and caused by stress. This is false. According to M.A.G.N.U.M., the National Migraine Association, “migraine is a disease, a headache is only a symptom.” A migraine sufferer can experience “nausea, vomiting, auras (light spots), sensitivity to light[, scent,] and sound, numbness, difficulty in speech, and severe semihemispherical head pain.” In addition, it is important to note that the cause of migraine pain has been found to be the opposite of the cause of most non-migranous headaches. Migraine pain is generally caused by the dilation of blood vessels in the brain, while other typical headaches appear to result from vasoconstriction. Further, migraines have been found to be genetically linked, where an individual has a 50% chance of suffering from migraines if one of his or her parents is a migraineur.
Myth 2: Migraines are caused solely by psychological factors.
Truth: While stress, depression, and anxiety can all worsen the symptoms of a migraine, they are rarely the sole cause. According to M.A.G.N.U.M., “migraine is a neurological disease, not a psychological disorder.” A migraine is a result of vasodilation in the cranial blood vessels, resulting in an overstimulation of the nerve synapses. Furthermore, migraines can be triggered by both controllable and uncontrollable factors. Controllable stimulants can include bright lights, loud noises, strong scents, and various foods (notably those that are aged or nitrate-latent). Uncontrollable triggers can include hormone changes and weather variations, including fluctuations in barometric pressure, temperature, and humidity. One can often lessen the risk of incidence of a migraine attack by reducing the controllable triggers. However, this is not always enough to fully prevent a migraine spell.
Myth 3: Any doctor should be able to effectively recognize and properly treat migraines.
Truth: Although members of the medical community are generally highly knowledgeable in their fields, migraines still remain one of the most misdiagnosed and mistreated diseases today. This is primarily due to the inherent lack of knowledge about and overall awareness of migraines and their symptoms. M.A.G.N.U.M. goes on to say that, “In fact, 60% of women and 70% of men with migraines have never been diagnosed with this disease.” These migraine sufferers are often misdiagnosed with clinical depression and/or other psychological disorders, leading doctors to mistreat them with various prescription drugs. Hopefully, as our understanding of this disease grows, we can educate both the medical community and the general public about migraines, in an attempt to vastly increase correct diagnoses and treatments.
According to Dr. Silberstein, M.D., F.A.C.P., Co-Director, The Comprehensive Headache Center at Germantown Hospital and Medical Center, in a letter to M.A.G.N.U.M., “Migraine sufferers must not only cope with their pain, but also with society’s misunderstanding of the disorder.” Therefore, both knowledge and education are paramount in the fight of ridding the stigmas surrounding this disease.
– Alexa Aaronson
Migraines: Myth Vs. Reality
Migraines and Headaches: Overview & Facts
Neurobiology of Migraine
When I read a book, I get so immersed in the lives of the characters, I find myself anxious and on edge even though I know Katniss’ and Peeta’s tragic romantic life have no bearing on my reality. The fact that characters fabricated from mere words can have this effect on us is pretty incredible. Roel Willems and Annabel Nijhof thought so too apparently, as they recently published a study revealing the neurological effects of listening to audiobooks.
In the experiment, researchers had the subjects listen to chapters of several different audiobooks and recorded their neurological responses using functional Magnetic Resonance Imaging (fMRI). By analyzing the results, Willems and Nijhof determined that the subjects focused most on either the actions of characters or the feelings and intentions of characters. In the subjects that reported to prefer empathizing with the characters more, the fMRIs showed heightened activity in the anterior medial prefrontal cortex, whereas those that reported enjoying the action aspect of the story more had elevated activity in the motor cortex. More
Shaking hands dates back centuries, with many cultural explanations to back up the ancient customs. One study suggests that the true reason we shake hands is to find out what this new friend smells like. Why? Smell is a “socially significant chemical signal,” used by many other species in social interactions. The researchers conducting this Weizmann Institute study hypothesize that shaking hands is a subliminal way for us to register the smell of others, a primal social custom that survived evolution.
To begin the experiment, the researchers needed to determine if a handshake was enough to transfer detectable body odor. One subject wore a glove on their right hand and the other did not. When the glove was tested after the two subjects shook hands, odor residues containing “meaningful chemical signals” were found on the glove. The next step was to determine the amount of time (if any) spent sniffing the right hand after shaking hands. Around three hundred volunteers, unaware of the purpose of the experiment, were greeted by researchers via a handshake. Surveillance cameras in the room recorded the scene and showed how much time subjects spend sniffing their hands after the encounter. To ensure the subjects were actually subconsciously smelling their hands, nasal air flow was also recorded.
Nothing is better than satisfying a craving for junk food. Be it Oreos, chips, or chocolate, digging into your favorite snack is probably the best feeling in the world. But what happens when junk food stops becoming a guilty pleasure and instead becomes a real addiction?
Research has discovered that sugar is more addictive than cocaine and that your brain becomes addicted to its own release of opioids in the reward system. The reward system in our brains evolutionarily benefited us by rewarding us for engaging in behavior that encouraged our survival. Thus, when we eat, the neurotransmitter dopamine (usually associated with happiness and pleasure) is released, causing the happy feeling you get when you satisfy a craving.
The world that we live in is one of easy access to sugar-rich foods and has lead to the normalization of overly sweet and processed foods in our everyday lives. Just like any addiction, tolerance to a substance may occur. In this case, constantly activating the reward system and releasing dopamine by continuously eating junk food can cause dopamine receptors to down-regulate. At this point, dopamine receptors are removed by the brain to maintain a balanced state. Fewer dopamine receptors prevent the same stimulation/effect created by dopamine release; thus we tend to eat more junk food to reach the same level of pleasure as before.
Sensory Processing Disorder(SPD) is a disorder that impairs processing of sensory information in the brain. For children it can cause klutziness, an inability to properly orient the body, poor fine motor skills, and a hypersensitivity to sound. In summary, this disorder makes it very difficult to process incoming information. The condition is very common for children and often is not properly diagnosed because until recently, there had not been a real biological explanation for the disorder. A very common treatment for these patients is occupational therapy.
We all feel scared, jumpy, or anxious but have you ever stopped to think why? Have you ever wondered why you get those goosebumps or why you feel that you are frozen sometimes? Just in time for Halloween, here is some information on how our body processes fear. According to NIMH, fear is defined as a feeling of disquiet that begins rapidly in the presence of danger and dissipates quickly once the threat is removed and is also generally adaptive. Fear is a primitive response.
While neuroscientists do not understand the pathways that we take to interpret fear, there are a few recent studies that examine this. In the first one, scientists identified specific neurons called SOM+ that are linked to a type of “fear memory” held in the amygdala.
Not one for sour food? Look no further than miracle berries – the fruit of the shrub Synsepalum dulcificum – to turn sour delicacies into sweet treats. A New York Times article reported the drastic changes in the taste sensation that consumers experienced after eating these berries. A tart concoction of lemon sorbet and Guinness tasted like a chocolate milkshake, a drizzle of tabasco sauce could have been mistaken for donut glaze – just one berry is enough to turn your taste buds upside down.
This miracle is achieved by the appropriately named miraulin, a glycoprotein contained in the fleshy portion of the berry. It binds to taste receptors on the taste buds, and for the most part does not affect taste sensation. However, when sour foods are consumed, the acid contained lowers the pH in the mouth. The miraculin on the receptors binds to the protons released by acidic substances, activating sweet receptors. It has been suggested that it changes the structure of taste receptors on the tongue, but any evidence towards this has been inconclusive. It is interesting to note that miraculin itself is not sweet.In fact, the berry has very little sugar.
Imagine you’re on your first date and you and your partner are hitting it off big time. It’s probably his/her witty comments or good sense of humor, his/her intelligence or impeccably beautiful smile that makes you feel extremely attracted to your date. As time goes on, you look deeply into each other’s eyes and giggle. You wonder, “am I falling in love?” The answer is: probably not (you’re only on your first date here, come on). You may not be falling in love, but you are feeling a stronger and closer bond being formed; and you’re feeling this way with some help from the hormones norepinephrine, dopamine, and oxytocin.
That’s right, kids– everything your parents told you about your crazy hormones when you had “The Talk” is true. Your hormones really are going crazy, and they really are helping you feel the way you do. When in love, areas in the brain that are known for their dopamine and norepinephrine production light up.