The Human Connectome Project (HCP) has started trials on volunteers with a state-of-the-art scanner.
Today’s technology allows neuroscientists to map the brain’s connections on an unprecedented level of detail. The ultimate goal of the HCP is to create a map, or connectome, of every neuron and synapse to better understand how the brain works. A better understanding of the brain means a better understanding of brain disorders like schizophrenia or autism, which in turn means better treatment.
By mapping the human brain, we will inevitably have a greater comprehensive understanding of how it functions. In this TED talk, Allan Jones explains how his team of researchers is mapping the brain by investigating which genes are turned on in each region and how these regions link up. According to Allan Jones: “Understanding how our genes are used in our brains will help scientists and the medical community better understand and discover new treatments for the full spectrum of brain diseases and disorders.”
Sometimes, writing is tough. The passion isn’t there, and every word is a struggle. We’ve all had those moments when forced to do something artistic or creative, whether it be writing or drawing or playing an instrument (or anything really). We’re just not into it, we don’t feel the pulse of the art pounding in our blood. Yet at other times, it’s like our blood rushes in a massive torrential pour, as if it had been held back by a massive dam for a thousand years. Whether its a subject that makes you jump for joy, a song you can head-bang to, or some other Picasso, some things just burst forth in a sudden and fervent explosion of productivity and creativity.
I think we’ve all had those moments when the pieces all click together, and a piece of work flows from us as easily as a hot knife through butter. During those moments, we feel alive, throbbing with a vibrant energy as our whole being is focused onto a single task. It’s an exhilarating feeling, yet at the same time, when you finally come down out of this strange natural high, it feels as though there was something slightly wrong about that, as if those who are capable of reaching that level often must have something wrong with them.
We live in an era where the rapid advances in technology are constantly changing how we perceive and interact with the world around us. The question on everyone’s mind is always “what’s next?” The answer: brain-machine interfaces. For the average consumer, brain-computer interfaces are becoming increasingly available on the mass market and their current uses offer a wide range of fascinating opportunities.
A company that’s been in the news a lot lately is NeuroVigil. Their product known as the iBrain has been used to help world-renowned astrophysicist Steven Hawking communicate with a computer simply by thinking. Hawking, who suffers from Lou Gehrig’s disease, developed his own solution to allow him to speak by twitching his cheek to select words from a computer. In its current state, the iBrain is still slower than Hawking’s solution, but NeuroVigil’s founder MD Philip Low hopes that it will eventually be possible to read thoughts aloud. NeuroVigil also made the news by signing a contract with Roche, a major Swiss pharmaceutical company, to use the iBrain in clinical studies for evaluating drugs for neurological diseases.
It’s Halloween, folks, and you know what that means: Jell-O molds of brains and punn-y costumes (Freudian Slip, anyone?), right? Amirite? Okay, maybe that’s just me, whatever, guys. But I can name at least one cherished Halloween pastime that tends to be pretty popular across the board, and that’s the horror movie marathon.
As we learned earlier this month, the mechanisms by which our brains process fear are intricate yet animalistic—after all, we’re by far not the only species that experiences the sensation of fear. Though what may be a uniquely human instinct is the propensity to actually seek out fear (and the sensation of arousal that inherently comes with it)—a concept illustrated nicely in this piece from The Dana Foundation. This purposeful seeking-out of fear-inducing stimuli is undoubtedly present in the act of partaking in the aforementioned horror movie marathon, and a particular subset of said scary flicks (and the characters therein) will serve as the main focus of this post.
There are lots of types of scary movies out there, from the psychological thriller to the slasher film and everything in between, but today, for the purposes of this entry, our interests lie in the psychopathic killers. Whether your allegiances fall with Freddy Kruger or Jason Voorhees, the psychopath is a popular character in cinema and in popular culture in general. But what makes this character profile so enjoyable and even attractive at times? And furthermore, what can we learn from the psychopaths among us?
Tanning is just one of those things, like chain smoking or base-jumping, that I’ve never cared to try; I am nowhere near athletic enough to attempt jumping off of a mountain face. I am also too, well, white to bask in the natural sun without SPF 50 sunscreen; like most people with skin of Fitzpatrick Scale type of I or II, I burn to a crisp and spend the next half-week smoothing aloe on my skin and crying in regret. More
There are numerous brain imaging techniques that allow us to gain insight into what damage the brain may have incurred after a patient has a traumatic injury. The ever popular fMRI measures blood flow to infer neural activity. Diffusion tensor imaging (DTI) uses the magnetic properties of water to look at white matter in the brain, while positron emission tomography (PET) uses radiolabeling to look for a specific chemical in the brain. All of these are important for possible disease diagnosis, however, there is skepticism around how dependent we should be on this technology, as the results should never be taken as the absolute truth.
Now, a new type of brain imaging developed by researchers at the University of Pittsburgh allows researchers to look for connections that have been broken as a result of traumatic brain injury, much like an X-Ray allows doctors to look for broken bones. It is called High Definition Fiber Tracking (HDFT). Although the technology is not specific at the cellular level, it is accurate in observing specific connections that have been lost as a result of injury. These lost connections act as a reliable predictor for cellular information, such as the percentage of axons that have been lost.
The accompanying publication in the Journal of Neurosurgery focuses on a case study of a man who sustained severe brain damage after crashing an all-terrain vehicle (public service announcement: this is why we wear helments!!!). Initial MRI scans showed hemorrhaging in the right basal ganglia, which was confirmed by a later DTI. The patient had extreme difficulty moving the left side of his body, and it was assumed to be a result of damage to the basal ganglia. It was not until the patient had a HDFT test that doctors could pinpoint the true problem: fiber tracts innervating the motor cortex had been lost. More
A research team led by Laura Matzen at Sandia National Laboratories in Albuqurque, NM has demonstrated that it is possible to predict how well people will remember information by monitoring their brain activity while studying. Matzen’s team monitored test volunteers with electroencephalography (EEG) sensors to make accurate predictions. Why bother making a prediction if the result will show how well someone remembered the information anyways? Matzen brought up this example, ”if you had someone learning new material and you were recording the EEG, you might be able to tell them, ‘You’re going to forget this, you should study this again,’ or tell them, ‘OK, you got it and go on to the next thing.” Essentially providing a real-time performance metric, the applications of which many students would appreciate. More
For many feminists, this effort to better understand female sexuality can be a means of empowerment, and it is not surprising that neuroscience research has branched into this area. Many people, rightfully so, believe that to understand our body and mind we must also understand the mechanisms of behavior in the brain. Yet due to its complexity, much of neuroscience research gets misinterpreted, reduced, or even generalized when written about for the public sphere.
Naomi Wolf’s Vagina: A New Biography, attempts to explain female sexuality by pulling from both subjective accounts and neuroscience to support her arguments. But what exactly does neuroscience research have to contribute to our knowledge of female sexuality? Although Wolf’s attempt at writing such a boldly stated book is admirable, it fell short, especially in terms of the science. Wolf misinterprets the roles of dopamine, oxytocin and serotonin in the brain and how they could plausibly influence a female’s romantic relationships.
As Maia Szalavits so eloquently wrote:
“The kind of oversimplification seen in Wolf’s book and, sadly, in many other popular accounts of neuroscience, threatens to perpetuate a psychological myth. Rather than illuminating the complex interplay between mind and body, it portrays human beings — especially women — as automatons, enslaved by brain chemicals we cannot control.”
So what does neuroscience have to say about female sexuality? At last year’s Society for Neuroscience Conference in Washington D.C., a 3D movie was presented of the brain during a female orgasm. Barry Komisaruk, a professor of psychology at Rutgers University, used fMRI (functional magnetic resonance imaging) to map brain activity in several women. The women were required to masturbate to an orgasm in the fMRI machine. (fMRI results are brain images reflecting activation in specific areas, and these areas are said to be lit up.) More
Social interaction and communication are essential characteristics of the human experience. As humans, we desire to create and develop relationships with each other. Autism Spectrum Disorder (ASD) is a neurological developmental condition that impairs this ability to relate. The spectrum refers to the fact that there are multiple conditions characterized by similar features all grouped together under this one disorder. These conditions include “classic” autism, Asperger syndrome, and Pervasive Developmental Disorder Not Otherwise Specified. There are also varying degrees of severity associated with ASD. So, depending on the disorder and degree to which a person suffers from this disorder, there is truly a wide spectrum of possible conditions created by ASD that many people around the world must deal with. More