Philosophers since the time of Plato have considered the extent to which we can truly perceive the physical world, or the so called ‘mind independent’ universe. Modern science has given us further insight into the question, through experiments designed to understand the way in which our brain receives and manipulates sensory information. While it has been known for some time that human perception is subject to various priming effects and spatiotemporal biases, psychologists at the University of California, Berkeley have discovered that visual perception is also influenced by something called the ‘continuity field.’
To put it simply, the continuity field is what allows us to view our surrounding environment as a continuous perception. In his recent article in Nature Neuroscience, David Whitney and his colleagues have shown that our perception of the orientation of a certain object in our visual field is actually strongly biased towards the orientation of that object 10 seconds prior. This means that our brain ‘smoothes out’ small changes in the physical world so that we perceive a continuous image. Without the influence of this continuity field, we would be hypersensitive to the smallest changes in our visual field, and presumably have trouble determining which changes in our surroundings would be most relevant to our immediate needs.
For years, the brain of a child with autism has been a mystery. Doctors and parents wondered about the cause of autism, and it seemed that they would never get those answers. Autism is characterized on a spectrum with various expressions of difficulty with social interaction including difficulty with verbal and nonverbal communication. Children with ASD (Autism Spectrum Disorder, the official title of ‘autism’ after the May 2013 publication of the DSM-5) are associated with difficulties with motor coordination, attention, intellectual disabilities, and physical health problems like sleep and gastrointestinal problems. Autism is usually presented by age three and the process of diagnosing autism continues to change, according to the Autism Speaks foundation.
Dr. Thomas R. Insel, director of NIMH at the NIH says that “while autism is generally considered a developmental brain disorder, research has not identified a consistent or causative lesion.” The newest reports show that the architecture of the autistic brain is “speckled with patches of abnormal neurons.” In the study published in the New England Journal of Medicine, there is evidence that the brain irregularities of children with autism are due to abnormal prenatal development.
Ever wonder why children can learn certain things, such as languages, faster than adults? There is a time in every human’s life called the critical period, and it takes place during the most intense period of development, childhood. During this time a child’s brain has high neuroplasticity, almost like a sponge. Many new pathways are formed as the child experiences new things. It has always been believed that when our critical period ends it never comes back but recent study has been done with the drug Valproate that increased neural plasticity in adults and may have reopened this critical period.
Valproate is a drug most commonly used for bipolar disorder and epilepsy. It is also known to inhibit an enzyme called histone- deacetylase, or HDAC. HDAC is an enzyme in the brain that slows down neural plasticity. Inhibition of this enzyme by Valproate allows the reopening of pathways in the brain, increasing neuroplasticity, thus reopening the critical period.
Most people are familiar with the idea that people who are blind have better hearing than those with normal vision. It was formerly thought that this compensation for lack of vision could only develop in the brains of the very young. However, new research conducted at the University of Maryland and Johns Hopkins University suggests that the brain may be more flexible than previously believed.
In the study, researchers kept one group of healthy mice in total darkness for a week, and exposed the other group to natural light for a week. Then the team used electrodes to measure activity in neurons in the mice’s primary auditory cortex. This is the part of the brain that processes how loud a sound is and its source. By analyzing this data, researchers found that the mice who were exposed to a week of darkness had much better hearing than the control mice.
This suggests that the circuits that process sensory information can be re-wired in the brains of adult mice, even after the early critical period for hearing. These findings seem to contradict the idea that once the critical period for hearing is past, the auditory system doesn’t respond to changes in an individual’s soundscape.
Pregnancy is…? This sentence can end in a multitude of ways depending on whose answering the question. If I ask the ‘teen-mom-too-good-to-be-true-seventeen year-old-boyfriend’ who isn’t worried about nothing, then he’d probably say…well I would’ve asked but he just stormed off in his 92′ Bronco. You know, the one with the flames on the side? If I ask the nervous husband who has been day dreaming of becoming that perfect family man ever since he got into the relationship, then he’d probably say: If it’s a girl, I will be the dragon that protects my princess’ castle. If I ask the soon-to-be-BIG-brother whose busy doing doughnuts in his fisher price corvette yelling “look mom, no hands,” he’d probably say: This doesn’t change the cookie rations, does it? And finally if I ask the pregnant mother-to-be
if she thinks she’s gained weight what she’s praying for, she’d probably say: Just not your father’s personality, PLEASE, not your father’s personality.
Pregnancy is engaging. It brings together families, can tear relationships apart, and creates changes in the daily routine. Most notable is women’s change in body size. Bodily size and the awareness of that size can create multiple obstacles. Typically, pregnant women are thought to be inhibited in their ability to adapt to these obstacles, however, pregnant women are just as capable as non-pregnant individuals. Today, we’ll discuss their ability to asses depth perception and whether or not they can fit through openings such as doorways. Thanks to perceptual-motor-recalibration, pregnant women are just as good at adjusting their spatial awareness of their environment to match their constantly changing bodies.
Schizophrenia is a mental disorder often presented in patients by abnormal thought processes, impaired emotional responses, and negative symptoms. As a chronic disorder that affects ~1% of all people, schizophrenia can be have debilitating effects on patients, especially on their social lives. Due to the lack of knowledge on its pathophysiology and also the heterogeneity of the symptoms, it has been increasingly important to understand the genetics of schizophrenia.
Due to the marked reduction in fecundity seen in schizophrenic patients, the high heritability of the disorder pointed to the possibility that genetic alleles that were risk factors might occur as de novo mutations. Previous exome sequencing studies showed no promising results, but the inconclusive results were likely due to small sample size and a narrow focus on target genes. Two recent studies, the largest of their kind, gathered data from nearly 7000 people (nearly 3500 patients) from Sweden and Bulgaria, and showed that genetic effects on schizophrenia seemed to be very complex. Specifically, both papers published in Nature reflected on the implication of genetic mutations in clusters of specific proteins that governed signaling networks dealing with learning and memory. The studies identified the presence of de novo mutations, often nonsense mutations, notably in genes related to the PSD (post-synaptic density of dendrites), the calcium channels, the postsynaptic ARC complex, and the NMDA receptors.
When the word meditation comes up, people usually think of Monks or Buddhists first. However, there is a reason they meditate so often; meditation does wonders for your brain, and here is how.
There are two main types of meditation: 1) Focused-attention meditation or ‘Mindful meditation‘ and 2) Open-monitoring meditation. In Mindful meditation, you focus on one specific thing ranging from your breathing, a specific sensation in your body, or a particular object in front of you.The key point is to focus on one thing without consideration to other thoughts or events happening around you. When any distractions occur, you must be quick to recognize it and turn your focus back to your focal point. Open-monitoring meditation is where you pay attention to all the things happening around you but you do not react to them.
If you have ever noticed that men tend to forget things quite often, especially compared to women, you are not alone. A research team led by Professor Jostein Holmen in Norway conducted a large, longitudinal population health study called Hunt3 to reach the conclusion that men are more forgetful than women, regardless of their age. This is one of the largest health studies ever performed, with answers from over 48,000 people leading to their conclusions.
The participants were asked at the beginning of the study if they had problems remembering things, if they had problems remembering dates and names, if they had a memory of what they did one year ago, and if they could remember details about specific conversations.
We know from everyday life that, at some point, we need to sleep. In fact, extended sleep deprivation can lead to death. Despite the amount of sleep research that has been conducted, none have been able to clearly reason out the essential function of sleep. However, recently, a promising study by Dr. Nedergaard showed that sleep functions in clearing neurotoxic waste from the brain of mice. In effect, without sleep, these toxins would build up and cause problems for the body.
Specifically, the study looked at what is known as the glymphatic system. Because our central nervous system lacks a lymphatic system which is in our peripheral system, the glymphatic clearance pathway is the primary way in which our brain can “clear” the cerebrospinal fluid (CSF) and interstital fluid (ISF) of the brain parenchyma. This clearance includes functions of getting rid of wastes, soluble proteins, and even controlling the volume of fluid. Interestingly, the Nedergaard study showed that this clearance system works faster when mice were asleep–in other words, the exchange rates of CSF and ISF increased during sleep. In addition, they were able to show that surrounding cells in the brain would shrink in size to allow more efficient clearance.
A groundbreaking new research study by Susumu Tonegawa’s team at MIT has opened up grounds for debate in the ethics of neuroscience once again. In Tonegawa’s experiment, neuroscientists were able to implant memories into the brains of mice using optogenetics, a technology in which specific cells can be turned on or off by exposure to a certain wavelength of light. The specific memory manipulated in this study was a conditioned fear response in mice to a mild electrical foot shock.
Researchers in Tonegawa’s lab began by engineering mice hippocampal cells to express channelrhodopsin, a protein that activates specific neurons when stimulated by light. Channelrhodopsin was also modified to be produced whenever c-fos, a gene necessary for memory formation, was turned on. On day one, the engineered mice explored Room A without any exposure to foot shock; the mice behaved normally. As the mice explored this room, their memory cells were labeled with channelrhodopsin. On day two, the same mice were placed into Room B, a distinctly different room, where a foot shock was received; the mice exhibited a fear response. While receiving the foot shocks, channelrhodopsin was activated via optogenetics causing the fear response to be encoding not only to Room B, but Room A as well. To test this hypothesis, the mice were brought back to Room A on day three.