Alcohol and Its Effect on the Brain

February 19th, 2018 in Uncategorized 0 comments

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When one thinks of parties, bars, or clubs, alcohol inevitably comes to mind. We drink before a party to help ourselves reduce anxiety and increase euphoria before dancing or mingling with other people. Because of these effects, alcohol has become the one of the most widely used recreational drugs in the world. So what exactly makes alcohol so appealing and why do we keep chasing after it despite knowing its negative effects in large doses?

With the first sip of the drink, we begin to see changes in two major neurotransmitters: GABA and glutamate. The increase in GABA keeps the brain calm while the glutamate keeps the brain active. The specific areas that are affected in the brain are the frontal lobe, which controls attention and planning, and the cerebellum, which controls movement. This is why after a few drinks, you may become uncoordinated and inhibited in your ability to think straight. After even more drinks, the levels of the neurotransmitters start to affect regions of the hippocampus, which can cause a loss of memory or black outs with increasing doses. After all the drinking has subsided, we leave our brain in a state to retune the neurotransmitter levels by itself, which could cause lasting damage if a heavy amount of alcohol was consumed. While an occasional drink has been shown to be healthy for the body, too much drinking leads to damage in the brain and a tendency towards alcoholism.

So how exactly do people become alcoholics? A study at Texas A&M has shown that alcohol seeking behavior may be a result of increasing connections between neurons in your brain. Through long-term potentiation, the pattern of activity described above is maintained. Wang et al. specifically tested this phenomenon by mimicking the effect of alcohol with optogenetics, which uses proteins sensitive to light to turn on and off certain regions in the brain. They used optogentics to recreate the memory and learning from alcohol, and both methods showed an increase in the strength of connections. With these findings, modulation of these regions in the brain may become an effective treatment for alcohol addictions. However, as exciting as these findings are, there is still a lot of research to be done before these methods can be used as treatments for addictions. In the meantime, drink cautiously and have fun!


Writer: Albert Wang

Editor: Sophia Hon


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How is the Brain Plastic?

February 15th, 2018 in Uncategorized 0 comments


For a long time, science has believe that the brain is “hard-wired” like a computer, suggesting that neuronal connections in the brain are completely fixed. However, when fMRI techniques were developed, scientists were able to view brain activity and the truth became clear that the brain is not static, but plastic. No, that doesn’t mean that the brain is literally made of plastic. What it does mean, though, is that our brains are malleable and able to change. The term “neuroplasticity” refers to the ability of the brain to reorganize its neuronal connections based on both external and internal stimuli, altering how we think and behave.

One way in which neuroplasticity affects our lives is by compensating for brain damage. If a brain region associated with a particular function is impaired, another brain region may take over that function. Strokes, injuries, birth abnormalities, PTSD, depression, and learning disabilities can be ameliorated thanks to the ability of the brain to reorganize itself. In addition to brain injury, neuroplasticity also plays a role in learning. If one becomes an expert in a specific skill, the corresponding brain regions associated with this skill may grow. One of the most common examples of this phenomenon occurs in the case of London taxi drivers. The hippocampus, partially involved in the formation of spatial representations of the environment, has been found to be larger among London taxi drivers samples. This is likely because their job requires them to navigate complex London streets. This kind of growth can be compared against the brains of London bus drivers, those who typically only need to follow a limited set of routes. Neuroplasticity can also play a role in other skills. The left parietal cortex, an area of the brain associated with language, is typically larger in those who are bilingual than in those who are monolingual. Another example of this would include musicians, whose motor regions, the anterior superior parietal areas and inferior temporal areas, have been observed to be larger than those of non-musicians.

Practicing mindfulness, meditation, doing aerobic exercise, learning a new instrument or language, and getting plenty of sleep are a few ways to increase your neuroplasticity. While it is true that your brain is much more plastic during your childhood and that plasticity declines with age, it is important to realize that even as you grow old, your brain always has the potential to change.

Writer: Nathaniel Meshberg

Editor: James Kunstle


Neuroplasticity: The 10 Fundamentals Of Rewiring Your Brain

Brain Plasticity: How learning changes your brain

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Why Cramming Probably Isn’t the Best Idea

December 10th, 2017 in Uncategorized 0 comments


Cramming. For one reason or another, be it poor time management or laziness, we’ve all pretty much done it at some point in our lives. Yes, it’s wrong and doesn’t really help to prepare well for tests, but have you ever considered why that is the case? What exactly is it about cramming that doesn’t quite agree with the brain and just ends up hurting test performance?

Cramming involves trying to memorize as much information as possible while only actually being able to encode some of the information as short-term memory. Whatever important material you’ve tried to memorize you will likely only be able to recognize and not recall because the information being encoded only includes surface level features. An example of this phenomenon would be rereading your notes: sensory areas of the brain such as the visual cortex will process the information and help you recognize what your notes look like, but other brain areas such as the frontal cortex and temporal lobe responsible for reconstructing a memory of the actual material which can then be recalled will not be active. On the other hand, long term memory encoding requires meaningful analysis of information as well as enough time to study to adequately process all the information you wish to store. Rewriting notes to make sense of them and constructing diagrams or pictures to relate different concepts are useful methods for creating a longer-lasting memory in your head – provided you do so well in advance, of course.

Another important problem to note about cramming is that it can interfere with the amount of sleep you get. Why is it important to be well-rested before an exam? Sleep, as it turns out, is vital for memory consolidation, a process where a short-term memory is stabilized into a long-term one as features of that memory become more connected. The hippocampus has been associated with memory consolidation: studies involving mice learning how to navigate mazes show that mice hippocampal neurons are active as they learn the maze and are actually reactivated during sleep, and this reactivation has been associated with strengthening of the new connections. What does all this mean? In the case where you have to choose between staying up all night to memorize as much information as you can and getting a good night’s sleep, choose getting a good night’s sleep. You won’t regret it.

Writer: Nathaniel Meshberg

Editor: Sophia Hon


Memory: Why cramming for tests often fails

Revising for exams – why cramming the night before rarely works

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Musical Training Can Lead to Better Speech Perception

December 5th, 2017 in Uncategorized 0 comments

learning music

Do you know how to play an instrument, such as a guitar, violin, or piano? Have you ever learned to recognize different notes or melodies in music? If so, you may have better speech perception than those who haven’t. A recent article published by Du et al. shows that musicians have an advantage in noise perception both on a behavioral level and on a neural level. In their behavioral study, they compared both musicians’ and non-musicians’ abilities to identify certain English phonemes alone or when combined with noise. Simultaneously, they used an fMRI to test their BOLD (blood oxygenation level-dependent) activity and ran a comparison between the two groups. Additionally, they looked at certain regions of interests (ROIs) from the fMRI and compared them using a multivoxel pattern analysis to see a difference in activation between regions. They found that long-term musical training helps with speech perception in noisy environments. This performance was correlated to an increase in activity in Broca’s area (a region in the frontal lobe linked to language processing and speech production), higher representations in auditory and motor regions, as well as stronger inter- and intra-hemispherical connectivity between auditory and motor regions. They ultimately found that musical training could lead to better auditory encoding, speech motor prediction, and auditory-motor integration that lead to better speech perception.

This study has quite a number of implications. With increased speech perception, you would be able to understand what someone is saying more quickly. This may benefit students in terms of taking down notes in lectures and comprehending lecture material. Better speech perception also has some clinical implications. Research by Kathleen et al. has shown that aging is related to a decrease in auditory processing. If musical training can increase speech perception, it may also have effects on auditory processing and thus decrease some of the negative symptoms associated with aging. These are all additional factors that need to be further studied, but the implications are very intriguing. Learning music is not only a good skill, but it may also have many beneficial effects. So in your spare time, learn how to play an instrument and differentiate between the sounds – you may be able to gain an upper hand in speech perception.

Writer: Albert Wang

Editor: Sophia Hon


Musical training sharpens and bonds ears and tongue to hear speech better

Effects of aging on auditory processing of speech

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What Is Glossophobia?

November 27th, 2017 in Uncategorized 0 comments

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Glossophobia is the medical term for the strong fear of public speaking. It is one of the most common phobias: about 75% of the world’s population struggle with this social phobia, or social anxiety disorder, to some extent. According to several surveys, the fear of public speaking is even greater than the fear of death.

Those who suffer from glossophobia tend to experience the classic fight or flight response when speaking in front of a group, even if the group only consists of a few people. They may tremble, sweat, freeze, and so on. As their brains release adrenaline and steroids, their blood sugar levels and heart rates increase. The symptoms are not necessarily limited to during a public speaking event; they can also happen prior to the event, that is, when it is anticipated. While glossophobic people may know that this fear is irrational, they have the least amount of power in controlling their feelings.

The exact cause of glossophobia is still unclear. However, genetic factors often play a huge role. Like many other phobias, glossophobia is more common in people who carry the corresponding characteristic from their families. Individuals with a family history of glossophobia or any similar fear may exhibit the symptoms when the fearful gene is activated. Certain traumatic events can also lead to glossophobia. You probably suffer from glossophobia and have a strong fear of being judged, embarrassed, or rejected because at some point in your life, you’ve experienced distressful situations, such as an unpleasant presentation you’ve given. Such events might not appear intense when they occur, but they can have a long-lasting impact. Another possible factor is education. Less educated people in general are more likely to feel uncomfortable with taking the stage. In one poll, 52% of respondents with a high school diploma or less expressed a fear of public speaking, compared to only 24% of college graduates. The consequence is that a glossophobic person is likely to deliberately avoid any public speaking scenarios.

Writer: Zijing Sang

Editor: Sophia Hon


Fear of Public Speaking Statistics and How to Overcome Glossophobia

Glossophobia: Fear of Public Speaking – Causes, Symptoms, and Treatment

Do You Suffer from Glossophobia?

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America’s Opioid Epidemic

November 20th, 2017 in Uncategorized 0 comments

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According to the NIH, 90 people in the U.S. die from overdosing on opioids every day. This rise in opioid usage began when a number of different opiate brands, such as Vicodin and Xanax, started being prescribed to more patients of different, usually younger, ages. In 2000, the average age of drug-related deaths was 40; now we are seeing more people in their 20s and 30s die from drug overdoses. The opioid crisis began with prescription opiates but has now culminated in the abuse of prescription drugs and recreational narcotics like heroin. But how has this epidemic taken so many lives? Well, the answer lies in how the brain develops tolerance and addiction to drugs such as opiates.

What happens to your nerves when you take an opiate? Most chemical signals land on receptors in the axon terminal of your nerve cells, which normally work by attaching to chemical signals that excite electrical impulses through your nerves. By taking opiates, those opiate chemical signals land on opioid receptors and inhibit the electrical impulses from ever traveling through the nerve cell.

There are 3 different kinds of opioid receptors – Mu, Kappa, and Delta. The Mu-opiate receptor is the most important in that it is responsible for activating all the symptoms and effects of taking opiates, such as constipation, pain numbing, euphoria, and depression. These opiate receptors are all-encompassing because they affect not only pain pathways but other parts of the brain such as the locus ceruleus, among other regions.

GABAergic receptors are the start of addiction and are located in the midbrain. GABAergic receptors are in charge of switching on or off the pleasure and pain networks of the brain, and opiates shut off these receptors to induce dopamine (the chemical that relieves anxiety and stress) to fill up the receptors. The secretion of dopamine conditions the brain to think that opiates are good for you and creates a tolerance. These GABAergic receptors adapt to the opiates within your body by producing more cyclic AMP to adjust for the inhibition of the electrical impulses in the nerve cells. Following the increase in cyclic AMP, nerve cells fire more electrical impulses, which cause the symptoms associated with withdrawal, such as diarrhea, dysphoria, and anxiety.

With the knowledge of what causes addiction, new research have arisen from this opioid epidemic. The Scripps Research Institute in Florida has developed a new form of opiate that decreases the risk of overdose while still substantially decreasing pain. This new drug decreases the respiratory suppression normally found in analgesia, which is the number one cause of death from overdosing. Another study from the University of Utah found that a compound from marine snails actually blocks pain pathway signals, which could become an alternative in the near future instead of prescription opiates. Another more popular alternative to pain management as well as withdrawal management is the use of medical marijuana. In a pilot study published in Trends in Neurosciences, cannabinoids are seen to decrease withdrawal symptoms by reducing drug cravings and even restored some neurological damage from prolonged drug abuse.

While this epidemic has taken hold of a larger portion of the U.S. than expected, it is only with the help of the researchers, scientists, and doctors that any damage from this opioid epidemic can be repaired.

Writer: Cindy Wu


Compound From Marine Snails Provide Alternative to Opioids

Medical Marijuana’s Underexplored Potential For Helping Opioid Addiction 

New Painkillers Reduce Overdose Risk

Short Answers to Hard Questions About the Opioid Crisis

How a brain gets hooked on opioids

Opioid Overdose Crisis

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Our Brain on the Maintenance of Eye Contact

November 12th, 2017 in Uncategorized 0 comments


Look at me while you’re talking!

If you’re anything like me, you probably have a hard time managing your eyes during conversations. Although eye contact is encouraged to maintain engagement with the other person, awkwardness could lead some to avert their gaze.

Turns out, according to Kajimura and Nomura (2016), our attempts to maintain eye contact and to rummage for the proper words are in competition for a domain general cognitive resource. To be more specific, when one tries to maintain eye contact, the default mode network is activated, which allows for self-consciousness and perception of others’ mindsets. On the other hand, verbal processing deactivates the default mode network and activates language networks. As a result, this competition between the two processes to either activate or deactivate the default mode network explains why eye contact hinders conversation. This ultimately generates an urge to break eye contact in order to facilitate verbal processing. Kajimura and Nomura’s conclusions came about from a word association game. When given a noun, the participants were asked to immediately respond with a verb that relates to the noun mentioned. For example, if the word “pie” was given, the participants would then respond with verbs such as, “eat”, “bake”, and so on. Moreover, this game was done while the participants stared at a face on a computer screen that would maintain eye contact and sometimes look away. The results showed that when faced with a challenging word, participants took longer to respond with a verb, but the response time was shorter if the participants broke eye contact.

Likewise, according to Glenberg et al. (1998), people might also avert their gaze if a question or topic being discussed has a high level of complexity or difficulty, and by averting their gaze, responses became more accurate. This study was done through a series of experiments. One of the experiments observed participants’ eye movements while they answered questions with varying levels of difficulty. In another experiment, participants were asked to answer general knowledge and mathematical questions while either closing their eyes or looking at the experimenter. The first experiment showed that participants showed a tendency to avert their gaze more as the difficulty of the questions increased. In the latter experiment, the participants scored more accurately when they had their eyes closed.

So if you ever notice someone breaking eye contact frequently, don’t take it too personally; they’re probably just trying to think. After all, what really matters in a conversation are the words being spoken and the thoughts behind them.

Author: Audrey Kim

Editor: Albert Wang


A possible explanation for why people find it hard to maintain eye contact when talking

Averting the gaze disengages the environment and facilitates remembering

When we cannot speak: Eye contact disrupts resources available to cognitive control processes during verb generation

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ASMR and What It Reveals About Your Personality

October 30th, 2017 in Uncategorized 0 comments

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Have you ever felt tingles in the back of your head or neck while listening to the sound of salmon sizzling on a pan, while watching someone folding clothes, or while getting a haircut? If the answer is yes, then you might experience Autonomous Sensory Meridian Response, or ASMR. The truth is, you are not alone. Although exactly how much of the general population experiences ASMR is unclear, a quick search for ASMR on YouTube now turns up more than 1.5 million videos. ASMR is a term used for an experience characterized by a variety of tingling physical sensations triggered by different acoustic, visual, and digital stimuli, from chopping to whispering, from washing to bubbling, etc. The most popular source of stimuli is video. For instance, the trendy Korean phenomenon known as mukbang, in which a vlogger eats surprisingly large quantities of food while chatting with the audience, has an ASMR spin on it: the audible eating sounds like chewing and crunching may evoke certain ASMR sensations in the brains of some viewers.

Stephen Smith, an associate professor of psychology at the University of Winnipeg, says that only a handful of scientific studies have been done on ASMR since the name itself sounds unscientific. ASMR is considered a perceptual sensory phenomenon rather than a response or a mental disorder, according to Smith.

ASMR is also associated with specific personality traits. In Smith’s study, 290 individuals with ASMR and 290 matched controls completed the Big Five Personality Inventory (BFI; John et al., 1991); participants with ASMR also completed a questionnaire related to their ASMR phenomenology. Results showed that people who experience ASMR demonstrated significantly higher scores on Openness and Neuroticism, and significantly lower levels of Conscientiousness, Extraversion, and Agreeableness compared to matched controls. Hence, if you experience ASMR, you probably tend to be more creative, have a broad range of interests, and are more likely to experience sadness, anxiety, and mood swings. Being low in Conscientiousness, Extraversion, and Agreeableness means that you are more likely to dislike a set schedule, feel exhausted when socializing, and take little interest in others.

Writer: Zijing Sang

Editor: Sophia Hon


The Big Five Personality Traits

An Examination of Personality Traits Associated with ASMR

Shh! These Quiet Food Videos Will Get Your Senses Tingling

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Lucid Dreaming and the Enigma of Our Consciousness

October 23rd, 2017 in Uncategorized 0 comments


The concept of lucid dreaming has been around since the time of the ancient Greeks and even exists as part of enlightenment in Tibetan Buddhism, described as “dream Yoga.” The scientific research regarding dreams and sleep itself is steadily increasing, yet it is somewhat of a new science to many neuroscientists. There are countless articles, videos, and how-to’s on the internet regarding how to start lucid dreaming, yet the true underlying cause of lucid dreaming and what exactly it means is still an area of active research among scientists. Recently, more studies have been conducted and have given more insight as to how consciousness is biologically connected to dreams.

Lucid dreaming is the act of retaining or gaining consciousness while still asleep, usually during the dreaming phase of sleep – Rapid Eye Movement (REM) sleep. While how-to’s and videos show how to lucid sleep, several research papers from Germany’s J.W. Goethe University and Max Planck Institute of Psychiatry have shed light to the various ways how scientists quantify instinctive and intuitive data from participants.

Goethe University has created the Lucidity & Consciousness in Dreams scale (LuCID) where participants who experienced lucid dreaming answered surveys regarding their lucid dreams. Researchers were able to quantify the survey’s data into the LuCID scale and concluded that those who lucid dream had greater control over their thoughts and actions within their dream, had the ability to think logically, and were better at accessing memories from their waking reality.  

Max Planck Institute also quantified their data from surveys and concluded that there were varying differences in participant’s states of consciousness. While in lucid dream, participants experienced better “intention enactment” just as Goethe’s study showed that participants had greater control over their thoughts and actions in their dream. Lucid dreamers were not shown to have a better planning ability than while awake. Both of these institutes have shown through their work that dreams and the consciousness are quantifiable to a certain degree, but there are other ways to measure the biological capabilities of the brain while during sleep as opposed to relying on secondhand accounts that are subject to human error.

Various other institutes and universities have been able to use a range of devices like MRI scans and EEGs to eye movement signals. The studies that used EEG and MRI scans showed that lucid dreaming showed an increase activity in the frontal areas of the brain, which are correlated to higher order cognitive functions and an increase in gamma wave activity, brain wave activity that consolidates brain inputs and turns them into memories and such.

While there is a pioneering effort to come to conclusions with the human brain’s consciousness and sleep states, all the research conducted so far is out of reach from obtaining a conclusive answer to how our brain completely functions. That being said, these studies in their own right show that there are correlations that take us one step closer to understanding our consciousness.  

Writer: Cindy Wu

Editor: Kawtar Bennani


High IQ and Its Effect on Health

October 17th, 2017 in Uncategorized 0 comments

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Money. Fame. Power. These are all things that come to mind when the topic of high intelligence is brought up. It is often thought that possessing high intelligence is advantageous; however, there may also be some negative consequences to such a gift. According to a study by Karpinski et al., possessing high intelligence may lead to the individual having a “hyper body,” or a body that has altered immune and inflammatory responses. To test this, they surveyed 3,715 members of Mensa, whose IQ were 130 or higher. Questions that were asked fell along the lines of reporting their experiences with mood and anxiety disorders, ADHD, autism spectrum disorder, as well as physiological diseases such as allergies or autoimmune diseases. The survey data was then compared against the national average for each disorder or disease. They found that the Mensa population had higher rates for all the diseases and that possessing a high IQ makes the chances of having a diagnosis 2 to 4 times more likely. This study explains that these effects may be due to the “overexcitabilities,” or intense behaviors that are psychomotor, sensual, emotional, intellectual, or imaginational, that are correlated with higher intelligence. Perhaps having a higher IQ means one’s entire body is more susceptible to the environment around them, leading to an increase in knowledge but also an increase in the risk factors as well.

Although high intelligence may lead to an increase in risk factors, it may also lead to an increase in life expectancy. Professor Deary and his colleagues at the University of Edinburgh carried out a study that compared the IQ of 11-year olds from 1932 and checked whether the cohort was alive at the age of 76. What they found was interesting: a 15-point IQ advantage led to a 21% greater survival rate. This shows that certain genes may link IQ and longevity, almost contradicting the previous study. More studies would need to be conducted in order to find the true correlation between IQ and health. Ultimately, having a high IQ can be seen as a double-edged sword: you may live a longer life, but you would also be more susceptible to risk factors throughout your life.

Writer: Albert Wang

Editor: Sophia Hon


High intelligence: A risk factor for psychological and physiological overexcitabilities

Research Confirms a Link between Intelligence and Life Expectancy

Dabrowski’s 5 Overexcitabilities in Gifted Children

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