The main focus of the lab is the differentiated smooth muscle cell, which forms the walls of most of the hollow organs in the body. Inappropriate contraction or relaxation of smooth muscle is responsible for a number of diseases including stroke, hypertension, heart failure, asthma and premature labor.
We have had a longstanding interest in the differentiated smooth muscle cell. We are currently focused on the vascular cells in the aorta. The proximal aorta normally functions as a critical shock absorber to prevent the full force of the heartbeat from reaching the delicate small blood vessels of the brain, kidney, and heart, where it would cause damage and lead to dementia, kidney failure and heart failure. This shock absorber function is impaired with age. Thus aortic stiffness is both an early biomarker of, and a contributor to, adverse aging-related cardiovascular outcomes. We have identified specific cytoskeletal protein-protein interfaces as being involved in aging-induced increased aortic stiffness in a mouse model. Our current efforts are focused on developing targeted potential therapeutic molecules to prevent or reverse the effects of aging on aortic stiffness and its consequent adverse cardiovascular and cognitive outcomes.
September 12, 2018
We have a new addition to the lab! Postdoc Chris Nicholson holds his son, Henry. Congratulations Chris!
July 18, 2018
Reversal of Aging-Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein-Protein Interfaces.
Our paper on treating aortic stiffness using decoy peptides was published in the Journal of the American Heart Association. Read the article here.
March 6, 2018
Hearts, Minds, and Microbubbles
The Morgan Lab, in collaboration with Dr. Tyrone Porter, is working to develop a localized drug delivery system that releases peptides directly into smooth muscle cells. The peptides are attached to microbubbles, which are guided through the bloodstream and burst using ultrasound waves, delivering the peptide. Read the article here.