Selected News from our Group

MDA Advisory Committee

May 22nd, 2015

On May 21-22, Jeff was in Chicago to attend a meeting of the Scientific Advisory Committee of the Muscular Dystrophy Association.

FSHD paper published

April 3rd, 2015

Clinical Epigenetics published a manuscript from our colleagues Takako Jones and Peter L. Jones at the University of Masschusetts on which Mary Lou Beermann, Sachiko Homma, and Jeff are co-authors. The work focuses on epigenetic mechanisms that regulate the level of DUX4 expression in FSHD myogenic cells. Read the paper here.

Two undergraduates to join for summer research

March 17th, 2015

Emily Misnick (Biomedical Engineering, ’15) and Bryant Yu (Cellular and Molecular Biology, ’16) will be joining us as undergraduate researchers this summer.

Two presentations at MDA conference

March 17th, 2015

At the recent MDA conference in Washington DC, our group had two presentations. Mary Lou Beermann presented our recent work on laminin-alpha-2-deficiency and Sachko Homma presented our recent work on FSHD.

FSHD paper highlighted

February 20th, 2015

The Winter 2015 edition of FSH Watch, the newsletter of the FSH Society, includes a profile of our recent paper in Ann. Clin. Transl. Neurol.

Our FSHD paper is published

January 17th, 2015

Our paper: “Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation” has now been published by Annals of Clinical and Translational Neurology in its early online view section.

Two abstracts for MDA conference

January 6th, 2015

Our group has submitted two abstracts to be presented at the upcoming MDA Conference in Washington DC March 11-14, 2015. The abstracts cover our new work in congenital and facioscapulohumeral dystrophies, with authors including Soonsang Yoon, Sachiko Homma, Mary Lou Beermann, Jeff and our MGH collaborator Rick Boyce.

Conference presentation highlighted

January 1st, 2015

The work presented by Jeff last summer at the New Directions in Skeletal Muscle Biology and Disease Conference was highlighted in both FSH Watch (Summer/Fall 2014, p20) and in a conference report published as: Wyatt et al. (2014) J. Neuromusc. Dis. 1:197-206.  Jeff’s talk was titled: “FSHD pathogenesis: Expression of DUX4-FL inhibits protein turnover and induces nuclear aggregation of TDP-43.”

Manuscript accepted for publication

November 18th, 2014

Our manuscript on DUX4-FL-induced aggregation of TDP-43 and inhibition of protein turnover has been accepted for publication by the Annals of Clinical and Translational Neurology, which is an official publication of the American Academy of Neurology.  Authors are Sachiko Homma, Mary Lou Beermann, Frederick M. Boyce (our collaborator at Massachusetts General Hospital), and Jeff.

Second FSHD paper submitted

October 15th, 2014

Takako I Jones, Peter L. Jones, and Charis Himeda (all of UMass Med) are lead authors, and we (Jeff, Mary Lou Beermann, and Sachiko Homma) are among the co-authors, on a manuscript about epigenetics and FSHD pathology that has just been submitted for review.

New FSHD manuscript submitted

August 25th, 2014

We’ve submitted a new manuscript on pathogenetic mechanisms in FSHD.  Authors are Sachiko Homma, Mary Lou Beermann, Frederick M. Boyce (our collaborator at Massachusetts General Hospital), and Jeff.

Jeff at Chicago Conference

July 2nd, 2014

Jeff gave a talk at the New Directions in Biology and Disease of Skeletal Muscle held this week in Chicago.  He spoke about the work done on FSHD with Sachiko Homma, Mary Lou Beermann, and Rick Boyce (MGH).

Summer fellows have started

June 3rd, 2014

Our two summer fellows, BU MD/PhD student, Chino Igwebuike, and BU undergraduate, Michaela Welch ’17, have started their projects in our group.

FSH Watch features MCB paper

May 31st, 2014

The Spring 2014 newsletter of the FSH Society includes an article that highlights the recent paper from Peter and Takako Jones at the University of Massachusetts on which we were co-authors. See page 15 of the FSH Watch here.

FSHD abstract submitted

April 28th, 2014

We’ve submitted an abstract on our FSHD work for presentation at the New Directions in Biology and Disease of Skeletal Muscle conference to be held in Chicago at the end of June.  Authors include our collaborator Rick Boyce (MGH), as well as Sachiko Homma, Mary Lou Beermann, and Jeff.

MCB accepts & publishes FSHD paper.

March 11th, 2014

Molecular and Cellular Biology has accepted and published our FSHD paper titled: “Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy associated DUX4 gene.”  The authors are: Charis L. Himeda, Céline Debarnot, Sachiko Homma, Mary Lou Beermann, Jeffrey B. Miller, Peter L. Jones, and Takako I. Jones. The lead authors, Charis Himeda, Peter Jones, and Takako Jones are at the University of Massachusetts Medical School. (Abstract in PubMed)

Two summer fellows to join us

February 28th, 2014

A BU undergraduate, Michaela Welch ’17, and a first year BU MD/PhD student, Chino Igwebuike, will be joining our group for summer research.

UROP & MSSRP summer positions available

January 30th, 2014

We invite undergraduates (to be supported by UROP) and first year Medical Students (support through MSSRP) to inquire about joining us for the summer of 2014.

Revised FSHD paper submitted

January 29th, 2014

Our colleagues Takako and Peter Jones have submitted a revised version of the FSHD mechanism paper on which Sachiko Homma, Mary Lou Beermann, and Jeff are co-authors.

New MDC1A paper published

December 6th, 2013

Our new MDC1A paper has been published in the journal Skeletal Muscle.  The title is: “Immortalized myogenic cells from Congenital Muscular Dystrophy Type1A patients recapitulate aberrant caspase activation in pathogenesis: A new tool for MDC1A research.” and the authors are Soonsang Yoon, Guido Stadler, Mary Lou Beermann, Eric V. Schmidt, James A. Windelborn, Peter Schneiderat, Woodring E. Wright and Jeff. (Read the article)

New MDC1A paper submitted

October 28th, 2013

With Dr. Soonsang Yoon as lead author, we’ve submitted a paper describing the immortalization of myogenic cells from human MDC1A patients and how these cells recapitulate aspects of pathology seen in muscle tissue.  Co-authors with Dr. Yoon include Dr. Guido Stadler and Dr. Woody Wright (UT Southwestern), Dr. Peter Schneiderat (Univ. Munich), Dr. J. Windelborn (UMass Med), Mary Lou Beermann and Eric Schmidt (BU) and Jeff.

FSHD International Consortium

October 22nd, 2013

Jeff, Mary Lou Beermann, Sachiko Homma, and Soonsang Yoon attended this year’s FSHD International Research Consortium Conference which was held at MIT this week. The ~100 attendees included academic scientists, biotech scientists, patient advocates, and representatives of funding agencies including the NIH, MDA, FSH Society, and FSH Global.

Jeff at MDA Scientific Advisory Committee Meeting

October 18th, 2013

In Tucson, Jeff took part in the fall meeting of the Scientific Advisory Committee of the Muscular Dystrophy Association on Friday, October 18th, 2013.

Eric Schmidt presents at Undergraduate Research Symposium

October 18th, 2013

Eric Schmidt presented a poster describing his work on culture of human myoblasts under low oxygen at BU’s Undergraduate Research Symposium today.

New FSHD manuscript submitted

September 18th, 2013

Takako I Jones, Peter L. Jones, and Charis Himeda (all of UMass Med) are lead authors, and we (Jeff, Mary Lou Beermann, and Sachiko Homma) are among the co-authors, on a manuscript about FSHD gene mechanisms that has just been submitted for review.