Emily Misnick, supported by a Clare Booth Luce award, and Bryant Yu, supported by an award from the BU Undergraduate Research Opportunities Program, have begun their summer projects in our lab. Welcome!
On May 21-22, Jeff was in Chicago to attend a meeting of the Scientific Advisory Committee of the Muscular Dystrophy Association.
Clinical Epigenetics published a manuscript from our colleagues Takako Jones and Peter L. Jones at the University of Masschusetts on which Mary Lou Beermann, Sachiko Homma, and Jeff are co-authors. The work focuses on epigenetic mechanisms that regulate the level of DUX4 expression in FSHD myogenic cells. Read the paper here.
Emily Misnick (Biomedical Engineering, ’15) and Bryant Yu (Cellular and Molecular Biology, ’16) will be joining us as undergraduate researchers this summer.
At the recent MDA conference in Washington DC, our group had two presentations. Mary Lou Beermann presented our recent work on laminin-alpha-2-deficiency and Sachko Homma presented our recent work on FSHD.
The Winter 2015 edition of FSH Watch, the newsletter of the FSH Society, includes a profile of our recent paper in Ann. Clin. Transl. Neurol.
Our paper: “Expression of FSHD-related DUX4-FL alters proteostasis and induces TDP-43 aggregation” has now been published by Annals of Clinical and Translational Neurology in its early online view section.
Our group has submitted two abstracts to be presented at the upcoming MDA Conference in Washington DC March 11-14, 2015. The abstracts cover our new work in congenital and facioscapulohumeral dystrophies, with authors including Soonsang Yoon, Sachiko Homma, Mary Lou Beermann, Jeff and our MGH collaborator Rick Boyce.
The work presented by Jeff last summer at the New Directions in Skeletal Muscle Biology and Disease Conference was highlighted in both FSH Watch (Summer/Fall 2014, p20) and in a conference report published as: Wyatt et al. (2014) J. Neuromusc. Dis. 1:197-206. Jeff’s talk was titled: “FSHD pathogenesis: Expression of DUX4-FL inhibits protein turnover and induces nuclear aggregation of TDP-43.”
Our manuscript on DUX4-FL-induced aggregation of TDP-43 and inhibition of protein turnover has been accepted for publication by the Annals of Clinical and Translational Neurology, which is an official publication of the American Academy of Neurology. Authors are Sachiko Homma, Mary Lou Beermann, Frederick M. Boyce (our collaborator at Massachusetts General Hospital), and Jeff.
Takako I Jones, Peter L. Jones, and Charis Himeda (all of UMass Med) are lead authors, and we (Jeff, Mary Lou Beermann, and Sachiko Homma) are among the co-authors, on a manuscript about epigenetics and FSHD pathology that has just been submitted for review.
We’ve submitted a new manuscript on pathogenetic mechanisms in FSHD. Authors are Sachiko Homma, Mary Lou Beermann, Frederick M. Boyce (our collaborator at Massachusetts General Hospital), and Jeff.
Jeff gave a talk at the New Directions in Biology and Disease of Skeletal Muscle held this week in Chicago. He spoke about the work done on FSHD with Sachiko Homma, Mary Lou Beermann, and Rick Boyce (MGH).
Our two summer fellows, BU MD/PhD student, Chino Igwebuike, and BU undergraduate, Michaela Welch ’17, have started their projects in our group.
The Spring 2014 newsletter of the FSH Society includes an article that highlights the recent paper from Peter and Takako Jones at the University of Massachusetts on which we were co-authors. See page 15 of the FSH Watch here.
We’ve submitted an abstract on our FSHD work for presentation at the New Directions in Biology and Disease of Skeletal Muscle conference to be held in Chicago at the end of June. Authors include our collaborator Rick Boyce (MGH), as well as Sachiko Homma, Mary Lou Beermann, and Jeff.
Molecular and Cellular Biology has accepted and published our FSHD paper titled: “Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy associated DUX4 gene.” The authors are: Charis L. Himeda, Céline Debarnot, Sachiko Homma, Mary Lou Beermann, Jeffrey B. Miller, Peter L. Jones, and Takako I. Jones. The lead authors, Charis Himeda, Peter Jones, and Takako Jones are at the University of Massachusetts Medical School. (Abstract in PubMed)
A BU undergraduate, Michaela Welch ’17, and a first year BU MD/PhD student, Chino Igwebuike, will be joining our group for summer research.
We invite undergraduates (to be supported by UROP) and first year Medical Students (support through MSSRP) to inquire about joining us for the summer of 2014.
Our colleagues Takako and Peter Jones have submitted a revised version of the FSHD mechanism paper on which Sachiko Homma, Mary Lou Beermann, and Jeff are co-authors.
Our new MDC1A paper has been published in the journal Skeletal Muscle. The title is: “Immortalized myogenic cells from Congenital Muscular Dystrophy Type1A patients recapitulate aberrant caspase activation in pathogenesis: A new tool for MDC1A research.” and the authors are Soonsang Yoon, Guido Stadler, Mary Lou Beermann, Eric V. Schmidt, James A. Windelborn, Peter Schneiderat, Woodring E. Wright and Jeff. (Read the article)
With Dr. Soonsang Yoon as lead author, we’ve submitted a paper describing the immortalization of myogenic cells from human MDC1A patients and how these cells recapitulate aspects of pathology seen in muscle tissue. Co-authors with Dr. Yoon include Dr. Guido Stadler and Dr. Woody Wright (UT Southwestern), Dr. Peter Schneiderat (Univ. Munich), Dr. J. Windelborn (UMass Med), Mary Lou Beermann and Eric Schmidt (BU) and Jeff.
Jeff, Mary Lou Beermann, Sachiko Homma, and Soonsang Yoon attended this year’s FSHD International Research Consortium Conference which was held at MIT this week. The ~100 attendees included academic scientists, biotech scientists, patient advocates, and representatives of funding agencies including the NIH, MDA, FSH Society, and FSH Global.
In Tucson, Jeff took part in the fall meeting of the Scientific Advisory Committee of the Muscular Dystrophy Association on Friday, October 18th, 2013.
Eric Schmidt presented a poster describing his work on culture of human myoblasts under low oxygen at BU’s Undergraduate Research Symposium today.