News and Events

New collaboration

May 22nd, 2019

We have set up a formal collaboration with Peter and Takako Jones who are at the University of Nevada at Reno School of Medicine. Funded by the Muscular Dystrophy Association, our work will focus on FSHD pathogenesis.

New lab member

April 30th, 2019

Isabel Masteika, soon to graduate from Hampshire College, will join the laboratory in early June. Welcome!

Trans-splicing paper published

February 19th, 2019

Our paper on trans-splicing has now been published by Scientific Reports and can be accessed here. The citation is:

Mitsuhashi, H., Homma, S., Beermann, M.L., Ishimaru, S., Takeda, H., Yu, B.K., Liu, K., Duraiswamy, S., Boyce, F.M., and Miller, J.B.(2019) Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers. Scientific Reports 9:2274 pp. 1-15. doi: 10.1038/s41598-018-36684-7

New MDA grant awarded

January 9th, 2019

The Muscular Dystrophy Association has awarded a new three year grant, with Jeff as P.I., to support our work on pathogenesis and therapeutic targets in FSHD.

Manuscript accepted for publication

November 20th, 2018

Our manuscript on mRNA trans-splicing has been accepted for publication:

Mitsuhashi, H., Homma, S., Beermann, M.L., Ishimaru, S., Takeda, H., Yu, B.K., Liu, K., Duraiswamy, S., Boyce, F.M., and Miller, J.B. (2018) Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers. Scientific Reports (in press).

New manuscript submitted

September 3rd, 2018

We've submitted a new manuscript describing development of an efficient system to generate trans-spliced mRNAs that encode covalent, head-to-tail protein multimers. Collaborators include Hiroaki Mitsuhashi (Tokai University) and Rick Boyce (Massachusetts General Hospital).

Presentation at FSHD Conference

June 11th, 2018

Our colleague, Dr. Sachiko Homma presented her work on mechanisms of DUX4-induced pathogenesis at the FSHD International Research Conference, which was held in Las Vegas, June 8-9.

New grant for Dr. Sachiko Homma

May 1st, 2018

Dr. Sachiko Homma in our group has been awarded a new grant from Friends of FSH Research to help support her work on mechanisms of pathogenesis in FSHD.

Boston’s March for Science 2018!

April 11th, 2018

Time to join together again! Join me at Christopher Columbus Park in Boston's North End on Saturday, April 14, 1-3 pm. Speakers, music, and camaraderie.

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FSHD paper accepted and published

April 4th, 2018

Our paper describing functional domains in the DUX4 protein has been accepted and published. Details are:

Mitsuhashi, H., Ishimaru, S., Homma, S., Yu, B., Honma, Y., Beermann, J.L., and Miller, J.B.(2018) Functional domains of the FSHD-associated DUX4 protein. Biology Open Apr 4. pii: bio.033977. doi: 10.1242/bio.033977. online access 

New paper submitted

March 5th, 2018

We've submitted a new manuscript for publication that describes our work on functional domains of the DUX4 protein in FSHD pathogenesis. Authors include members of the group led by our collaborator Dr. Hiroaki Matsuhashi at Tokai University in Japan, as well as Sachiko Homma, Mary Lou Beermann, Bryant Yu and Jeff from our group at the Boston University School of Medicine.

Jeff publishes birding field note

February 1st, 2018

Jeff has published a field note: "2E2: A Successful Gull" in the February, 2018 issue of Bird Observer, which is the the birding journal of New England. The online version of the article is available here.

New paper accepted and published

December 20th, 2017

Our paper on mechanisms of pathogenesis in MDC1A (laminin-alpha-2-deficiency) has been accepted and published by the Journal of Neuromuscular Diseases. Details:

Yoon, S., Beermann, M.L., Yu, B., Shao, D., Bachschmid, M., and Miller, J.B. (2018) Aberrant caspase activation in laminin-α2-deficient human myogenic cells is mediated by p53 and sirtuin activity. J. Neuromusc. Dis. 5: 59-73. published online Dec 20, 2017. doi: 10.3233/JND-170262. PubMed PMID: 29278895. online access

UROP Symposium presentation

October 20th, 2017

Sweta Duraiswamy gave a presentation on her summer work investigating DUX4 function and structure at the BU undergraduate research symposium.

New manuscript submitted

August 15th, 2017

We've submitted a new manuscript for publication in which we describe our studies of pathogenesis in laminin-alpha2-deficiency (MDC1A). This study has a particular focus on aberrant intracellular signaling, including p53, sirtuins, and protein kinases.

Jeff publishes Canvasback duck article

August 1st, 2017

Jeff has published this article in the journal Bird Observer in which he discusses the history and current status of Canvasback Ducks in New England. The work arose from his observations at Fresh Pond in Cambridge, Massachusetts.

UROP student begins

June 6th, 2017

Swetha Duraiswamy has begun her summer research project on DUX4-mediated mechanisms of pathology. She is supported by the Undergraduate Research Opportunities Program at Boston University.

Boston’s March for Science!

April 22nd, 2017

It was an inspiring day at today's Boston March for Science! Tens of thousands braved the cold and rainy weather, including hundreds and hundreds of children who made good use of the many kids-themed activity tables. Former EPA administrator (and Boston native) Gina McCarthy gave an especially motivating and fiery speech. Very glad I could join everyone there!

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UROP fellowship to Swetha Duraiswamy

March 25th, 2017

The Undergraduate Research Opportunities Program at Boston University has awarded a fellowship to Swetha Duaraiswamy to support her summer work in our laboratory. Congrats!

Join Jeff at the Boston March for Science

March 11th, 2017

April 22, 2017 -- if you can't make it to D.C., then consider joining New England scientists and supporters of science at the Boston Common from 1pm - 4pm. Details are here:  marchforscienceboston.com

New summer student

February 27th, 2017

Swetha Duraiswamy, who is in BU's seven year Liberal Arts/Medical Education program, will be joining us this summer as an undergraduate researcher.  Swetha has previous research lab experience at Brown University.

FSH Society grant

February 11th, 2017

The FSH Society has made an award to support the work of Dr. Sachiko Homma on DUX4-induced mechanisms of pathogenesis.

Myogenesis and FSHD paper published

December 2nd, 2016

Our new paper has been published by Skeletal Muscle. We focus on reorganization of nuclear bodies (nucleoli, PML bodies, SC35 speckles) during normal myogenesis and on how expression of DUX4 affects these nuclear structures that are key to regulation of gene expression. The paper is available here.

FSHD paper accepted for publication

November 15th, 2016

Homma, S., Beermann, M.L., Yu, B., Boyce, F.M., and Miller, J.B. (2016) Nuclear bodies reorganize during myogenesis and are differentially disrupted by expression of FSHD-associated DUX4. Skeletal Muscle (in press)

Work presented at FSHD conference

November 10th, 2016

Sachiko Homma, Mary Lou Beermann, and Bryant Yu presented our work on how nuclear body organization is affected by DUX4 expression at the FSHD Research Connects Symposium.