We have set up a formal collaboration with Peter and Takako Jones who are at the University of Nevada at Reno School of Medicine. Funded by the Muscular Dystrophy Association, our work will focus on FSHD pathogenesis.
Isabel Masteika, soon to graduate from Hampshire College, will join the laboratory in early June. Welcome!
Our paper on trans-splicing has now been published by Scientific Reports and can be accessed here. The citation is:
Mitsuhashi, H., Homma, S., Beermann, M.L., Ishimaru, S., Takeda, H., Yu, B.K., Liu, K., Duraiswamy, S., Boyce, F.M., and Miller, J.B.(2019) Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers. Scientific Reports 9:2274 pp. 1-15. doi: 10.1038/s41598-018-36684-7
The Muscular Dystrophy Association has awarded a new three year grant, with Jeff as P.I., to support our work on pathogenesis and therapeutic targets in FSHD.
Our manuscript on mRNA trans-splicing has been accepted for publication:
Mitsuhashi, H., Homma, S., Beermann, M.L., Ishimaru, S., Takeda, H., Yu, B.K., Liu, K., Duraiswamy, S., Boyce, F.M., and Miller, J.B. (2018) Efficient system for upstream mRNA trans-splicing to generate covalent, head-to-tail, protein multimers. Scientific Reports (in press).
We've submitted a new manuscript describing development of an efficient system to generate trans-spliced mRNAs that encode covalent, head-to-tail protein multimers. Collaborators include Hiroaki Mitsuhashi (Tokai University) and Rick Boyce (Massachusetts General Hospital).
Our colleague, Dr. Sachiko Homma presented her work on mechanisms of DUX4-induced pathogenesis at the FSHD International Research Conference, which was held in Las Vegas, June 8-9.
Dr. Sachiko Homma in our group has been awarded a new grant from Friends of FSH Research to help support her work on mechanisms of pathogenesis in FSHD.
Time to join together again! Join me at Christopher Columbus Park in Boston's North End on Saturday, April 14, 1-3 pm. Speakers, music, and camaraderie.
Our paper describing functional domains in the DUX4 protein has been accepted and published. Details are:
Mitsuhashi, H., Ishimaru, S., Homma, S., Yu, B., Honma, Y., Beermann, J.L., and Miller, J.B.(2018) Functional domains of the FSHD-associated DUX4 protein. Biology Open Apr 4. pii: bio.033977. doi: 10.1242/bio.033977. online access
We've submitted a new manuscript for publication that describes our work on functional domains of the DUX4 protein in FSHD pathogenesis. Authors include members of the group led by our collaborator Dr. Hiroaki Matsuhashi at Tokai University in Japan, as well as Sachiko Homma, Mary Lou Beermann, Bryant Yu and Jeff from our group at the Boston University School of Medicine.
Jeff has published a field note: "2E2: A Successful Gull" in the February, 2018 issue of Bird Observer, which is the the birding journal of New England. The online version of the article is available here.
Our paper on mechanisms of pathogenesis in MDC1A (laminin-alpha-2-deficiency) has been accepted and published by the Journal of Neuromuscular Diseases. Details:
Yoon, S., Beermann, M.L., Yu, B., Shao, D., Bachschmid, M., and Miller, J.B. (2018) Aberrant caspase activation in laminin-α2-deficient human myogenic cells is mediated by p53 and sirtuin activity. J. Neuromusc. Dis. 5: 59-73. published online Dec 20, 2017. doi: 10.3233/JND-170262. PubMed PMID: 29278895. online access
Sweta Duraiswamy gave a presentation on her summer work investigating DUX4 function and structure at the BU undergraduate research symposium.
We've submitted a new manuscript for publication in which we describe our studies of pathogenesis in laminin-alpha2-deficiency (MDC1A). This study has a particular focus on aberrant intracellular signaling, including p53, sirtuins, and protein kinases.
Jeff has published this article in the journal Bird Observer in which he discusses the history and current status of Canvasback Ducks in New England. The work arose from his observations at Fresh Pond in Cambridge, Massachusetts.
Swetha Duraiswamy has begun her summer research project on DUX4-mediated mechanisms of pathology. She is supported by the Undergraduate Research Opportunities Program at Boston University.
It was an inspiring day at today's Boston March for Science! Tens of thousands braved the cold and rainy weather, including hundreds and hundreds of children who made good use of the many kids-themed activity tables. Former EPA administrator (and Boston native) Gina McCarthy gave an especially motivating and fiery speech. Very glad I could join everyone there!
The Undergraduate Research Opportunities Program at Boston University has awarded a fellowship to Swetha Duaraiswamy to support her summer work in our laboratory. Congrats!
April 22, 2017 -- if you can't make it to D.C., then consider joining New England scientists and supporters of science at the Boston Common from 1pm - 4pm. Details are here: marchforscienceboston.com
Swetha Duraiswamy, who is in BU's seven year Liberal Arts/Medical Education program, will be joining us this summer as an undergraduate researcher. Swetha has previous research lab experience at Brown University.
The FSH Society has made an award to support the work of Dr. Sachiko Homma on DUX4-induced mechanisms of pathogenesis.
Our new paper has been published by Skeletal Muscle. We focus on reorganization of nuclear bodies (nucleoli, PML bodies, SC35 speckles) during normal myogenesis and on how expression of DUX4 affects these nuclear structures that are key to regulation of gene expression. The paper is available here.
Homma, S., Beermann, M.L., Yu, B., Boyce, F.M., and Miller, J.B. (2016) Nuclear bodies reorganize during myogenesis and are differentially disrupted by expression of FSHD-associated DUX4. Skeletal Muscle (in press)
Sachiko Homma, Mary Lou Beermann, and Bryant Yu presented our work on how nuclear body organization is affected by DUX4 expression at the FSHD Research Connects Symposium.