Current projects in the lab are aimed at:
1) Mechanistically defining how the Hippo pathway maintains chromosome stability.
2) Identifying the cellular defects that trigger activation of the Hippo tumor suppressor pathway.
3) Characterizing novel activators of the Hippo pathway.
4) Assessing the consequences of Hippo pathway reactivation on cancer cell viability.
5) Defining how oncogenic signaling disrupts mitotic fidelity and chromosome segregation.