People

h_15-8759-GANEM-071

The Ganem Lab. From left to right: Allison Matthews, Amanda Bolgioni (MED’17), Neil Ganem, Sanghee Lim (MED’19), Elizabeth Shenk (ENG’16), and Hatim Mustaly (MED’15).

 

Current Members

DSC_0015-857x1024

Neil J. Ganem, Ph.D.,  Assistant Professor of Pharmacology and Medicine, Division of Hematology and Medical Oncology

Neil Ganem received his PhD in Biochemistry from the Geisel School of Medicine at Dartmouth where he studied mechanisms of mitotic spindle assembly and chromosome movement in the lab of Duane Compton. As a postdoctoral fellow in David Pellman’s lab at the Dana-Farber Cancer Institute at Harvard Medical School, he studied mechanisms of chromosome stability and the role of tetraploidy in tumorigenesis. He started his lab at the Boston University School of Medicine (BUSM) in September 2013.

 

 

 

 

 

 

IMG_9820

Kristyna Kotynkova, Ph.D., Postdoctoral Researcher

Kristyna joined the lab in August 2016 as a postdoctoral associate. During her postgraduate work at the London Research Institute, she studied the role of protein Ect2 in cleavage furrow formation and cytokinesis in the labs of Mark Petronczki and Stephen West. In 2015, Kristyna received her PhD in Cell Biology from University College London. Kristyna’s undergraduate research at the Institute of Microbiology, Academy of Sciences of the Czech Republic, was focused on biochemical and biophysical studies of NK cell receptors. She completed her master’s degree in Biochemistry at the Charles University in Prague in 2011. Kristyna’s research in the Ganem Lab is focused on the role of the Hippo pathway in maintaining chromosome stability.

 

 

 

 

fotoBeatrizCortez1

Beatriz Cortez, Ph.D., Postdoctoral Researcher

Beatriz is a visiting postdoctoral fellow from the University of Sao Paulo, Brazil. She joined the Ganem Lab in May 2017 to conduct research for one year. During her master’s and PhD, received in 2010 and 2014, respectively, Beatriz was interested in the behavior of aneuploid cells. She studied how asbestos exposure can lead to aneuploid cell formation, and how multipolar spindles and aneuploid cells arise after vincristine treatment. During this period under the supervision of Glaucia Santelli at the University of Sao Paulo, Beatriz also joined, for short periods of time, the labs of Alfredo Caceres in Argentina and Stephen Doxsey in the US. As a postdoctoral fellow, Beatriz joined the lab of Oswaldo Keith Okamoto from the The Human Genome and Stem Cell Reseacrh Center at the University of Sao Paulo, where she has been studying the role of Hippo pathway in cancer stem cells. 

 

 

 

Amanda

Amanda Bolgioni, Graduate Student in Pharmacology

Amanda is a doctoral student in the Department of Pharmacology and Experimental Therapeutics at BUSM. She joined the Ganem Lab in May, 2014. Amanda completed her undergraduate degree in Biochemistry at the University of Vermont (UVM) in 2013. Her undergraduate research at UVM was performed under Dr. Gary Mawe and focused on the importance of serotonin for gastrointestinal function, specifically how this neurotransmitter contributes to inflammatory bowel disease and irritable bowel syndrome when its regulation is altered.  Amanda’s research in the Ganem Lab is aimed at understanding the role of the Hippo tumor suppressor pathway in regulating the “mitotic clock,” governing mitotic cell fate, and maintaining chromosome stability.

 

 

 

 

Sanghee Lim Photo

Sanghee Lim, Graduate Student in Pharmacology

Sanghee Lim is an MD/PhD candidate in the Department of Pharmacology and Experimental Therapeutics. He joined Dr. Ganem’s lab in the summer of 2014 following the completion of his pre-clinical studies at the BUSM. Sanghee graduated from the College of Arts and Sciences at Boston University (BU) through the Seven-Year Medical Education program with a degree in Medical Science and a degree with Honors in Political Science. As an undergraduate at BU, Sanghee worked with Dr. Herbert Cohen in the Renal Section at Boston Medical Center, investigating the relationship between Jade-1 (Gene for Apoptosis and Differentiation in Epithelia-1) and invasive phenotypes in models of renal cell carcinoma. Sanghee’s current work in the Ganem Lab focuses on elucidating novel mechanisms of genome instability as incurred by expression of oncogenic BRAF V600E in melanomas. As a side project, Sanghee is also working on identifying novel molecular regulators of the Hippo tumor suppressor pathway through both molecular and bioinformatics approaches.

 

 

 

Unknown

Ryan Quinton, Graduate Student in Pharmacology

Ryan Quinton is an MD/PhD candidate in the Department of Pharmacology and Experimental Therapeutics at BUSM. He joined the Ganem Lab in September 2015. Ryan graduated from Brigham Young University in 2013 with a degree in Molecular Biology then went on complete his pre-clinical training at Boston University School of M. As an undergraduate Ryan began performing biology research studying minnows in the streams of Southwestern Wyoming. This required too much sleeping outdoors and so Ryan transitioned to cancer research in the lab of Dr. Kim O’Neill at BYU where his work focused on macrophages in the tumor microenvironment. He then joined the lab of Dr. Mike Engel at the Huntsman Cancer Institute at the University of Utah School of Medicine where he studied the role of Notch pathway elements in erythropoiesis. Ryan’s work in the Ganem Lab focuses on understanding the Hippo tumor suppressor pathway’s role in cancer development.

 

 

 

IMG_0223

Marc Vittoria, Graduate Student in Pharmacology

Marc Vittoria is an MD/PhD candidate in the Department of Pharmacology and Experimental Therapeutics. He joined the Ganem Lab in the summer of 2016. Marc graduated from New York University with a degree in Biochemistry back in 2014 before matriculating into the MD/PhD program at BUSM. During his undergraduate years, he performed research into alpha-helix mimetics and organic catalysts in the lab of Dr. Arora. Though chemistry is always fun, it was time for Marc to move on to biologic-based research, more in line with his ultimate goal of becoming a physician. Currently, Marc’s work involves assessing possible novel regulators of the Hippo pathway while also exploring new research ideas.

 

 

 

 

06904bb

Victoria Kacprzak, Lab Manager

Victoria joined the Ganem Lab as a research technician in June 2015 after completing her undergraduate degree in Neuroscience and Psychology at BU in May 2015. As an undergraduate, she worked with Dr. Irina V. Zhdanova from the Department of Anatomy & Neurobiology at BUSM, characterizing the effects of cocaine and methamphetamine in dopamine-transporter knockout zebrafish. Victoria is currently pursuing a Master in Business Administration in Health Sector Management at the BU Questrom School of Business. She was recently promoted to lab manager of the Dahod Center of Breast Cancer Research.

 

 

 

 

Unknown

Shiyi Jiang, Undergraduate Student

Shiyi is an undergraduate student continuing her junior year this coming fall. She majors in Biology specialization in Cell, Molecular and Genetics (CMG) at BU. She joined the Ganem Lab in May 2016. She’s now exploring her interest on cancer studies.

 

 

 

 

 

Past Members

Elizabeth

Elizabeth Shenk, Graduate Student in Biomedical Engineering/ Pharmacology

Elizabeth was the first PhD student to join the Ganem Lab, in the fall of 2013. A biomedical engineering and pharmacology student, she was the first PhD student to graduate from the Ganem Lab, graduating in May 2016 after investigating mechanisms of tetraploidy-induced tumorigenesis. Specifically, Elizabeth identified miRNAs that can enable tetraploid cell proliferation. In a separate project, she identified the propensity of the nuclear envelopes of micronuclei to rupture. Elizabeth is currently working at Alliance Pharma, a small company in Pennsylvania where she’s happy to be back amongst Penn State fans wherever she goes.

 

 

 

 

 

Jasmine

Jasmine Vakhshoorzadeh, Graduate Student in Pharmacology

Jasmine joined the Ganem Lab in July 2015 as a second-year student in the Master of Science in Medical Science Program (MAMS) at BUSM. Her project was to explore the role of the Hippo pathway in breast cancer development and progression. Prior to joining the Ganem Lab, Jasmine earned her undergraduate degree in Biology at Boston University in 2011, and a Master of Public Health, with a concentration in Environmental Health, also at Boston University in 2013.

 

 

 

 

 

Tenny

Tenny Mudianto, Undergraduate Student

Tenny joined the Ganem Lab in the Fall of 2014 as a junior at BU. She graduated from BU in May 2016, majoring in Cell & Molecular Biology and minoring in Music Performance.  After taking several biology courses in college, she developed an interest in cancer research. In the Ganem Lab,  Tenny’s project was to examine the role of the protein p38 in the Hippo Pathway. She started working as a research technician in The Hammerman Lab at the Dana Farber Cancer Institute in summer 2016. Tenny plans to pursue graduate studies in biochemistry.

 

 

 

 

Hatim

Hatim Mustaly, Masters Student in Medical Sciences

Hatim Mustaly joined the Ganem Lab as a second year graduate student pursuing a Masters Medical Sciences at BUSM, Division of Graduate Medical Sciences in 2014. At the Ganem lab, he worked on small molecule modulators of the Hippo tumor suppressor pathway. Following the master’s program, Hatim matriculated at BUSM’s MD class of 2019.

 

 

 

 

 

Allison

Allison Matthews, Research Technician (2013-2015)

Allison was a research technician and the first hire of the Ganem Lab. She joined the lab in July of 2013 after completing her undergraduate degree in Biochemistry at Mount Holyoke College in May 2013. She is currently pursuing a PhD in Molecular Microbiology in the MERGE-ID program at Tufts Medical School.