Laboratory of Cancer Cell Biology


The Ganem Lab. From left to right, front: Shiyi Jiang (CAS’18), Victoria Kacprzak, Sanghee Lim (MED’20) and Amanda Bolgioni (MED’18). From left to right, back: Kristyna Kotynkova, Ryan Quinton (MED’21), Neil Ganem, Marc Vittoria (MED’22) and Beatriz Cortez.

Our laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, bioinformatics, and animal model systems to study the causes and consequences of aneuploidy and chromosome instability in human cancer. We also aim to define the tumor suppression mechanisms that  limit the proliferation of aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.