Laboratory of Cancer Cell Biology

The Ganem Lab. From left to right, front: Amanda Didomizio, Reyna Joint, Neil Ganem and Sheena Patel. From left to right, back: Carlos Ticas, Kristyna Kotynkova, Marc Vittoria (MED’22), Ryan Quinton (MED’21)and Kristen Segars.

Our laboratory uses a combination of high-resolution microscopy, genome-wide RNAi screening, bioinformatics, and animal model systems to study the causes and consequences of aneuploidy and chromosome instability in human cancer. We also aim to define the tumor suppression mechanisms that  limit the proliferation of aneuploid cells, as well as to identify the common genetic adaptations made by cancer cells to overcome these growth barriers.